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Volume 17, Number 21, Issue of November 1, 1997 pp. 8613-8620
Copyright ©1997 Society for Neuroscience

Decreased Frequency But Not Amplitude of Quantal Synaptic Responses Associated with Expression of Corticostriatal Long-Term Depression

Received May 29, 1997; revised Aug. 11, 1997; accepted Aug. 22, 1997.

Sukwoo Choi¹ and David M. Lovinger^{1, 2}

Departments of ¹ Molecular Physiology and Biophysics and ² Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615

We have investigated the site of expression of striatal long-term synaptic depression (LTD) using analysis of Sr²⁺-induced asynchronous release of quanta from stimulated synapses. The cumulative amplitude distribution of Sr²⁺-induced asynchronous synaptic responses overlaps with that of miniature EPSCs (mEPSCs), suggesting that Sr²⁺-induced asynchronous responses are quantal. Quantal amplitude at stimulated synapses is not significantly altered after LTD induction, whereas quantal frequency decreases after LTD induction. The decrease in quantal frequency is prevented when LTD expression is blocked by dialyzing 10 mM EGTA into the postsynaptic neuron. Our findings are most consistent with the idea that expression of striatal LTD involves decreased neurotransmitter release with no change in quantal amplitude, despite the fact that induction of striatal LTD involves postsynaptic mechanisms.

Key words: long-term depression; striatum; cortex; synaptic plasticity; presynaptic expression; postsynaptic induction

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