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Volume 17, Number 22, Issue of November 15, 1997 pp. 8880-8893

Functional Properties of Perigeniculate Inhibition of Dorsal Lateral Geniculate Nucleus Thalamocortical Neurons In Vitro

Received June 17, 1997; revised Aug. 4, 1997; accepted Aug. 28, 1997.

Maria V. Sanchez-Vives and David A. McCormick

Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510

The properties of the inhibitory influence of neurons in the perigeniculate (PGN) nucleus on thalamocortical cells were examined with intracellular recordings in the ferret geniculate slice maintained in vitro. Activation of PGN neurons with the local application of glutamate caused IPSPs in thalamocortical neurons that were mediated by both GABA_A and GABA_B receptors, as well as the activation of spindle waves.

With low intensity stimulation of the PGN, local application of bicuculline to the dorsal lateral geniculate nucleus (LGNd) strongly inhibited evoked and spindle-associated IPSPs, indicating that these are largely mediated by GABA_A receptors. The generation of GABA_B receptor-mediated IPSPs in thalamocortical cells that were large enough to generate rebound low threshold Ca²⁺ spikes required substantially increased activation of the PGN with glutamate.

The activation of synchronous bicuculline-induced slowed oscillations in thalamocortical neurons required the block of GABA_A receptors in the LGNd as well as in the PGN. These results indicate that bursts of action potentials in PGN neurons can result in the activation of both GABA_A and GABA_B receptors in thalamocortical neurons, with the strong activation of GABA_B receptors requiring an intense, simultaneous discharge of a number of PGN neurons. Functionally, these results suggest that PGN neurons inhibit thalamocortical cells preferentially through the activation of GABA_A receptors, although the strong activation of GABA_B receptors may occur under pathological conditions and contribute to the generation of abnormal, synchronous slow oscillations.

Key words: inhibition; thalamus; sleep; thalamic reticular nucleus; GABAergic; oscillations

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