QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (33) Citing Articles via Google Scholar Google Scholar Articles by Holmes, T. C. Articles by Levitan, I. B. Search for Related Content PubMed PubMed Citation Articles by Holmes, T. C. Articles by Levitan, I. B.

 Previous Article  |  Next Article 

Volume 17, Number 23, Issue of December 1, 1997 pp. 8964-8974

Expression of Voltage-Gated Potassium Channels Decreases Cellular Protein Tyrosine Phosphorylation

Received June 11, 1997; revised Aug. 29, 1997; accepted Sept. 16, 1997.

Todd C. Holmes, Kevin Berman, Jill E. Swartz, Daniel Dagan, and Irwin B. Levitan

Department of Biochemistry and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254

Protein tyrosine phosphorylation by endogenous and expressed tyrosine kinases is reduced markedly by the expression of functional voltage-gated potassium (Kv) channels. The levels of tyrosine kinase protein and cellular protein substrates are unaffected, consistent with a reduction in tyrosine phosphorylation that results from inhibition of protein tyrosine kinase activity. The attenuation of protein tyrosine phosphorylation is correlated with the gating properties of expressed wild-type and mutant Kv channels. Furthermore, cellular protein tyrosine phosphorylation is reduced within minutes by acute treatment with the electrogenic potassium ionophore valinomycin. Because tyrosine phosphorylation in turn influences Kv channel activity, these results suggest that reciprocal modulatory interactions occur between Kv channel and protein tyrosine phosphorylation signaling pathways.

Key words: delayed-rectifier potassium channel; protein tyrosine kinase; src; epidermal growth factor receptor; modulation; phosphorylation

This article has been cited by other articles:

				P. Szigligeti, L. Neumeier, E. Duke, C. Chougnet, K. Takimoto, S. M. Lee, A. H. Filipovich, and L. Conforti Signalling during hypoxia in human T lymphocytes - critical role of the src protein tyrosine kinase p56Lck in the O2 sensitivity of Kv1.3 channels J. Physiol., June 1, 2006; 573(2): 357 - 370. [Abstract] [Full Text] [PDF]

				R. Vicente, A. Escalada, M. Coma, G. Fuster, E. Sanchez-Tillo, C. Lopez-Iglesias, C. Soler, C. Solsona, A. Celada, and A. Felipe Differential Voltage-dependent K+ Channel Responses during Proliferation and Activation in Macrophages J. Biol. Chem., November 21, 2003; 278(47): 46307 - 46320. [Abstract] [Full Text] [PDF]

				Z. Tiran, A. Peretz, B. Attali, and A. Elson Phosphorylation-dependent Regulation of Kv2.1 Channel Activity at Tyrosine 124 by Src and by Protein-tyrosine Phosphatase epsilon J. Biol. Chem., May 2, 2003; 278(19): 17509 - 17514. [Abstract] [Full Text] [PDF]

				P. Jin, T. M. Weiger, and I. B. Levitan Reciprocal Modulation between the alpha and beta 4 Subunits of hSlo Calcium-dependent Potassium Channels J. Biol. Chem., November 8, 2002; 277(46): 43724 - 43729. [Abstract] [Full Text] [PDF]

				M. N. Nitabach, D. A. Llamas, I. J. Thompson, K. A. Collins, and T. C. Holmes Phosphorylation-Dependent and Phosphorylation-Independent Modes of Modulation of Shaker Family Voltage-Gated Potassium Channels by Src Family Protein Tyrosine Kinases J. Neurosci., September 15, 2002; 22(18): 7913 - 7922. [Abstract] [Full Text] [PDF]

				E. M. Slimko, S. McKinney, D. J. Anderson, N. Davidson, and H. A. Lester Selective Electrical Silencing of Mammalian Neurons In Vitro by the Use of Invertebrate Ligand-Gated Chloride Channels J. Neurosci., September 1, 2002; 22(17): 7373 - 7379. [Abstract] [Full Text] [PDF]

				V. Heidinger, P. Manzerra, X. Q. Wang, U. Strasser, S.-P. Yu, D. W. Choi, and M. M. Behrens Metabotropic Glutamate Receptor 1-Induced Upregulation of NMDA Receptor Current: Mediation through the Pyk2/Src-Family Kinase Pathway in Cortical Neurons J. Neurosci., July 1, 2002; 22(13): 5452 - 5461. [Abstract] [Full Text] [PDF]

				M. J. Davis, X. Wu, T. R. Nurkiewicz, J. Kawasaki, P. Gui, M. A. Hill, and E. Wilson Regulation of ion channels by protein tyrosine phosphorylation Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H1835 - H1862. [Abstract] [Full Text] [PDF]

				C.-H. Yeung and T.G. Cooper Effects of the ion-channel blocker quinine on human sperm volume, kinematics and mucus penetration, and the involvement of potassium channels Mol. Hum. Reprod., September 1, 2001; 7(9): 819 - 828. [Abstract] [Full Text] [PDF]

				D. A. Fadool, K. Tucker, J. J. Phillips, and J. A. Simmen Brain Insulin Receptor Causes Activity-Dependent Current Suppression in the Olfactory Bulb Through Multiple Phosphorylation of Kv1.3 J Neurophysiol, April 1, 2000; 83(4): 2332 - 2348. [Abstract] [Full Text] [PDF]

				Z. Qian, D. Okuhara, M. K. Abe, and M. R. Rosner Molecular Cloning and Characterization of a Mitogen-activated Protein Kinase-associated Intracellular Chloride Channel J. Biol. Chem., January 15, 1999; 274(3): 1621 - 1627. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help