 |
 Previous Article | Next Article 
Volume 17, Number 23,
Issue of December 1, 1997
pp. 9104-9112
Developmental Regulation of Basket/Stellate Cell Purkinje Cell
Synapses in the Cerebellum
Received June 24, 1997; revised Aug. 15, 1997; accepted Sept. 12, 1997.
Christophe Pouzat1 and
Shaul Hestrin2
1 Arbeitsgruppe Zelluläre Neurobiologie,
Max-Planck-Institut für Biophysikalische Chemie, D-37077
Göttingen, Germany, and 2 Department of Anatomy and
Neurobiology, College of Medicine, University of Tennessee,
Memphis, Tennessee 38163
We used paired recordings to study the development of synaptic
transmission between inhibitory interneurons of the molecular layer and
Purkinje cells in the cerebellar cortex of the rat. The
electrophysiological data were combined with a morphological study of
the recorded cells using biocytin or Lucifer yellow staining. Thirty-one interneuron-Purkinje cell pairs were obtained, and 11 of
them were recovered morphologically. The age of the rats ranged from 11 to 31 d after birth. During this period synaptic maturation
resulted in an 11-fold decrease in the average current evoked in a
Purkinje cell by a spike in a presynaptic interneuron. Unitary IPSCs in
younger animals exhibited paired-pulse depression, whereas paired-pulse
facilitation was found in more mature animals. These data suggest that
reduction in transmitter release probability contributed to the
developmental decrease of unitary IPSCs. However, additional mechanisms
at both presynaptic and postsynaptic loci should also be considered.
The decrease of the average synaptic current evoked in a Purkinje cell
by an action potential in a single interneuron suggests that as
development proceeds interneuron activities must be coordinated to
inhibit efficiently Purkinje cells.
Key words:
inhibitory synapses;
cerebellum;
paired recordings;
development;
single-axon IPSCs;
stellate cells;
basket cells
This article has been cited by other articles:
|
|
|
|
 
D. Feldmeyer and G. Radnikow
Developmental alterations in the functional properties of excitatory neocortical synapses
J. Physiol.,
May 1, 2009;
587(9):
1889 - 1896.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Corlew, D. J. Brasier, D. E. Feldman, and B. D. Philpot
Presynaptic NMDA Receptors: Newly Appreciated Roles in Cortical Synaptic Function and Plasticity
Neuroscientist,
December 1, 2008;
14(6):
609 - 625.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. F. Atherton, D. L. Wokosin, S. Ramanathan, and M. D. Bevan
Autonomous initiation and propagation of action potentials in neurons of the subthalamic nucleus
J. Physiol.,
December 1, 2008;
586(23):
5679 - 5700.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Huang, H. Yasuda, A. Sarihi, and T. Tsumoto
Roles of Endocannabinoids in Heterosynaptic Long-Term Depression of Excitatory Synaptic Transmission in Visual Cortex of Young Mice
J. Neurosci.,
July 9, 2008;
28(28):
7074 - 7083.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A.-M. M. Oswald and A. D. Reyes
Maturation of Intrinsic and Synaptic Properties of Layer 2/3 Pyramidal Neurons in Mouse Auditory Cortex
J Neurophysiol,
June 1, 2008;
99(6):
2998 - 3008.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. H. Barmack and V. Yakhnitsa
Functions of Interneurons in Mouse Cerebellum
J. Neurosci.,
January 30, 2008;
28(5):
1140 - 1152.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Astori and G. Kohr
Sustained granule cell activity disinhibits juvenile mouse cerebellar stellate cells through presynaptic mechanisms
J. Physiol.,
January 15, 2008;
586(2):
575 - 592.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Frick, D. Feldmeyer, and B. Sakmann
Postnatal development of synaptic transmission in local networks of L5A pyramidal neurons in rat somatosensory cortex
J. Physiol.,
November 15, 2007;
585(1):
103 - 116.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. F. Trigo, M. Chat, and A. Marty
Enhancement of GABA Release through Endogenous Activation of Axonal GABAA Receptors in Juvenile Cerebellum
J. Neurosci.,
November 14, 2007;
27(46):
12452 - 12463.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Orduz and I. Llano
Recurrent axon collaterals underlie facilitating synapses between cerebellar Purkinje cells
PNAS,
November 6, 2007;
104(45):
17831 - 17836.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Corlew, Y. Wang, H. Ghermazien, A. Erisir, and B. D. Philpot
Developmental Switch in the Contribution of Presynaptic and Postsynaptic NMDA Receptors to Long-Term Depression
J. Neurosci.,
September 12, 2007;
27(37):
9835 - 9845.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. Liu
Biphasic Modulation of GABA Release From Stellate Cells by Glutamatergic Receptor Subtypes
J Neurophysiol,
July 1, 2007;
98(1):
550 - 556.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Arsenault and Z.-w. Zhang
Developmental remodelling of the lemniscal synapse in the ventral basal thalamus of the mouse
J. Physiol.,
May 15, 2006;
573(1):
121 - 132.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Mejia-Gervacio and A. Marty
Control of interneurone firing pattern by axonal autoreceptors in the juvenile rat cerebellum
J. Physiol.,
February 15, 2006;
571(1):
43 - 55.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Youssoufian, S. Oleskevich, and B. Walmsley
Development of a Robust Central Auditory Synapse in Congenital Deafness
J Neurophysiol,
November 1, 2005;
94(5):
3168 - 3180.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. L. Smith and T. S. Otis
Pattern-dependent, simultaneous plasticity differentially transforms the input-output relationship of a feedforward circuit
PNAS,
October 11, 2005;
102(41):
14901 - 14906.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Casel, J. Brockhaus, and J. W Deitmer
Enhancement of spontaneous synaptic activity in rat Purkinje neurones by ATP during development
J. Physiol.,
October 1, 2005;
568(1):
111 - 122.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. D. Nosyreva and K. M. Huber
Developmental Switch in Synaptic Mechanisms of Hippocampal Metabotropic Glutamate Receptor-Dependent Long-Term Depression
J. Neurosci.,
March 16, 2005;
25(11):
2992 - 3001.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kirischuk, R. Juttner, and R. Grantyn
Time-matched pre- and postsynaptic changes of GABAergic synaptic transmission in the developing mouse superior colliculus
J. Physiol.,
March 15, 2005;
563(3):
795 - 807.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Mittmann, U. Koch, and M. Hausser
Feed-forward inhibition shapes the spike output of cerebellar Purkinje cells
J. Physiol.,
March 1, 2005;
563(2):
369 - 378.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. L. Fiszman, A. Barberis, C. Lu, Z. Fu, F. Erdelyi, G. Szabo, and S. Vicini
NMDA Receptors Increase the Size of GABAergic Terminals and Enhance GABA Release
J. Neurosci.,
February 23, 2005;
25(8):
2024 - 2031.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Conti, Y. P. Tan, and I. Llano
Action Potential-Evoked and Ryanodine-Sensitive Spontaneous Ca2+ Transients at the Presynaptic Terminal of a Developing CNS Inhibitory Synapse
J. Neurosci.,
August 4, 2004;
24(31):
6946 - 6957.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-X. Chen and S. N. Roper
Tonic Activity of Metabotropic Glutamate Receptors Is Involved in Developmental Modification of Short-Term Plasticity in the Neocortex
J Neurophysiol,
August 1, 2004;
92(2):
838 - 844.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z.-w. Zhang
Maturation of Layer V Pyramidal Neurons in the Rat Prefrontal Cortex: Intrinsic Properties and Synaptic Function
J Neurophysiol,
March 1, 2004;
91(3):
1171 - 1182.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. F. Keller, J.-D. Breton, R. Schlichter, and P. Poisbeau
Production of 5{alpha}-Reduced Neurosteroids Is Developmentally Regulated and Shapes GABAA Miniature IPSCs in Lamina II of the Spinal Cord
J. Neurosci.,
January 28, 2004;
24(4):
907 - 915.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Mori-Kawakami, K. Kobayashi, and T. Takahashi
Developmental decrease in synaptic facilitation at the mouse hippocampal mossy fibre synapse
J. Physiol.,
November 15, 2003;
553(1):
37 - 48.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Diana and A. Marty
Characterization of Depolarization-Induced Suppression of Inhibition Using Paired Interneuron-Purkinje Cell Recordings
J. Neurosci.,
July 2, 2003;
23(13):
5906 - 5918.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Dean, S. J. Robertson, and F. A. Edwards
Serotonin Drives a Novel GABAergic Synaptic Current Recorded in Rat Cerebellar Purkinje Cells: A Lugaro Cell to Purkinje Cell Synapse
J. Neurosci.,
June 1, 2003;
23(11):
4457 - 4469.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Angulo, J. F. Staiger, J. Rossier, and E. Audinat
Distinct Local Circuits Between Neocortical Pyramidal Cells and Fast-Spiking Interneurons in Young Adult Rats
J Neurophysiol,
February 1, 2003;
89(2):
943 - 953.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Li and R. E. Burke
Developmental Changes in Short-Term Synaptic Depression in the Neonatal Mouse Spinal Cord
J Neurophysiol,
December 1, 2002;
88(6):
3218 - 3231.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Galarreta and S. Hestrin
Electrical and chemical synapses among parvalbumin fast-spiking GABAergic interneurons in adult mouse neocortex
PNAS,
September 17, 2002;
99(19):
12438 - 12443.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kirischuk, J. D Clements, and R. Grantyn
Presynaptic and postsynaptic mechanisms underlie paired pulse depression at single GABAergic boutons in rat collicular cultures
J. Physiol.,
August 15, 2002;
543(1):
99 - 116.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Sara, M. G. Mozhayeva, X. Liu, and E. T. Kavalali
Fast Vesicle Recycling Supports Neurotransmission during Sustained Stimulation at Hippocampal Synapses
J. Neurosci.,
March 1, 2002;
22(5):
1608 - 1617.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. G. Mozhayeva, Y. Sara, X. Liu, and E. T. Kavalali
Development of Vesicle Pools during Maturation of Hippocampal Synapses
J. Neurosci.,
February 1, 2002;
22(3):
654 - 665.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kawa
Acute synaptic modulation by nicotinic agonists in developing cerebellar Purkinje cells of the rat
J. Physiol.,
January 1, 2002;
538(1):
87 - 102.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Shi, S. M. Aamodt, M. Townsend, and M. Constantine-Paton
Developmental Depression of Glutamate Neurotransmission by Chronic Low-Level Activation of NMDA Receptors
J. Neurosci.,
August 15, 2001;
21(16):
6233 - 6244.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Iwasaki and T. Takahashi
Developmental regulation of transmitter release at the calyx of Held in rat auditory brainstem
J. Physiol.,
August 1, 2001;
534(3):
861 - 871.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Dieudonne
Book Review: Serotonergic Neuromodulation in the Cerebellar Cortex: Cellular, Synaptic, and Molecular Basis
Neuroscientist,
June 1, 2001;
7(3):
207 - 219.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Vicini, C. Ferguson, K. Prybylowski, J. Kralic, A. L. Morrow, and G. E. Homanics
GABAA Receptor {alpha}1 Subunit Deletion Prevents Developmental Changes of Inhibitory Synaptic Currents in Cerebellar Neurons
J. Neurosci.,
May 1, 2001;
21(9):
3009 - 3016.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Taschenberger and H. von Gersdorff
Fine-Tuning an Auditory Synapse for Speed and Fidelity: Developmental Changes in Presynaptic Waveform, EPSC Kinetics, and Synaptic Plasticity
J. Neurosci.,
December 15, 2000;
20(24):
9162 - 9173.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Caillard, H. Moreno, B. Schwaller, I. Llano, M. R. Celio, and A. Marty
Role of the calcium-binding protein parvalbumin in short-term synaptic plasticity
PNAS,
November 2, 2000;
(2000)
230362997.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
F. Saitow, S.'I. Satake, J. Yamada, and S. Konishi
beta -Adrenergic Receptor-Mediated Presynaptic Facilitation of Inhibitory GABAergic Transmission at Cerebellar Interneuron-Purkinje Cell Synapses
J Neurophysiol,
October 1, 2000;
84(4):
2016 - 2025.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Forti, C. Pouzat, and I. Llano
Action potential-evoked Ca2+ signals and calcium channels in axons of developing rat cerebellar interneurones
J. Physiol.,
August 15, 2000;
527(1):
33 - 48.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Takahashi and D. J. Linden
Cannabinoid Receptor Modulation of Synapses Received by Cerebellar Purkinje Cells
J Neurophysiol,
March 1, 2000;
83(3):
1167 - 1180.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Iwasaki, A. Momiyama, O. D. Uchitel, and T. Takahashi
Developmental Changes in Calcium Channel Types Mediating Central Synaptic Transmission
J. Neurosci.,
January 1, 2000;
20(1):
59 - 65.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Reyes and B. Sakmann
Developmental Switch in the Short-Term Modification of Unitary EPSPs Evoked in Layer 2/3 and Layer 5 Pyramidal Neurons of Rat Neocortex
J. Neurosci.,
May 15, 1999;
19(10):
3827 - 3835.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Mann-Metzer and Y. Yarom
Electrotonic Coupling Interacts with Intrinsic Properties to Generate Synchronized Activity in Cerebellar Networks of Inhibitory Interneurons
J. Neurosci.,
May 1, 1999;
19(9):
3298 - 3306.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Angulo, J. F. Staiger, J. Rossier, and E. Audinat
Developmental Synaptic Changes Increase the Range of Integrative Capabilities of an Identified Excitatory Neocortical Connection
J. Neurosci.,
March 1, 1999;
19(5):
1566 - 1576.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Pouzat and A. Marty
Somatic Recording of GABAergic Autoreceptor Current in Cerebellar Stellate and Basket Cells
J. Neurosci.,
March 1, 1999;
19(5):
1675 - 1690.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Pouzat and A. Marty
Autaptic inhibitory currents recorded from interneurones in rat cerebellar slices
J. Physiol.,
June 15, 1998;
509(3):
777 - 783.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Bureau and C. Mulle
Potentiation of GABAergic synaptic transmission by AMPA receptors in mouse cerebellar stellate cells: changes during development
J. Physiol.,
June 15, 1998;
509(3):
817 - 831.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kondo and A. Marty
Synaptic currents at individual connections among stellate cells in rat cerebellar slices
J. Physiol.,
May 15, 1998;
509(1):
221 - 232.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Caillard, H. Moreno, B. Schwaller, I. Llano, M. R. Celio, and A. Marty
Role of the calcium-binding protein parvalbumin in short-term synaptic plasticity
PNAS,
November 21, 2000;
97(24):
13372 - 13377.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kawa
Acute synaptic modulation by nicotinic agonists in developing cerebellar purkinje cells of the rat
J. Physiol.,
December 3, 2001;
(2001)
200101288.
[Abstract]
[PDF]
|
|
|
|
