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Volume 17, Number 23,
Issue of December 1, 1997
pp. 9104-9112
Developmental Regulation of Basket/Stellate Cell Purkinje Cell
Synapses in the Cerebellum
Received June 24, 1997; revised Aug. 15, 1997; accepted Sept. 12, 1997.
Christophe Pouzat1 and
Shaul Hestrin2
1 Arbeitsgruppe Zelluläre Neurobiologie,
Max-Planck-Institut für Biophysikalische Chemie, D-37077
Göttingen, Germany, and 2 Department of Anatomy and
Neurobiology, College of Medicine, University of Tennessee,
Memphis, Tennessee 38163
We used paired recordings to study the development of synaptic
transmission between inhibitory interneurons of the molecular layer and
Purkinje cells in the cerebellar cortex of the rat. The
electrophysiological data were combined with a morphological study of
the recorded cells using biocytin or Lucifer yellow staining. Thirty-one interneuron-Purkinje cell pairs were obtained, and 11 of
them were recovered morphologically. The age of the rats ranged from 11 to 31 d after birth. During this period synaptic maturation
resulted in an 11-fold decrease in the average current evoked in a
Purkinje cell by a spike in a presynaptic interneuron. Unitary IPSCs in
younger animals exhibited paired-pulse depression, whereas paired-pulse
facilitation was found in more mature animals. These data suggest that
reduction in transmitter release probability contributed to the
developmental decrease of unitary IPSCs. However, additional mechanisms
at both presynaptic and postsynaptic loci should also be considered.
The decrease of the average synaptic current evoked in a Purkinje cell
by an action potential in a single interneuron suggests that as
development proceeds interneuron activities must be coordinated to
inhibit efficiently Purkinje cells.
Key words:
inhibitory synapses;
cerebellum;
paired recordings;
development;
single-axon IPSCs;
stellate cells;
basket cells
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