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 Previous Article
Volume 17, Number 23,
Issue of December 1, 1997
pp. 9384-9391
CaM Kinase II and Visual Input Modulate Memory Formation in the
Neuronal Circuit Controlling Courtship Conditioning
Received July 8, 1997; revised Sept. 5, 1997; accepted Sept. 19, 1997.
Mei-ling A. Joiner and
Leslie C. Griffith
Department of Biology and Volen Center for Complex Systems,
Brandeis University, Waltham, Massachusetts 02254-9110
In Drosophila, calcium/calmodulin-dependent protein
kinase II (CaM kinase) has been shown to be important in the
expression of both learning and memory for the associative
behavior courtship conditioning. In this study we examine the role of
visual input in producing this behavior and the effects of modifying
visual input on CaM kinase-dependent memory formation. Inhibition of CaM kinase blocked apparent learning regardless of visual input. Visual
input selectively affected the memory phase of courtship conditioning:
normal visual input masked the memory effects of inhibition of CaM
kinase resulting in generation of memory without apparent learning,
whereas disruption of visual input revealed the CaM kinase-dependence
of memory. Visual input was found to be important only during the
training period, which implies that vision and CaM kinase are
interacting in the formation rather than the retrieval of memory. Our
results suggest a model for courtship conditioning in which multiple
sensory inputs are integrated at a CaM-kinase-dependent neuronal switch
to modulate courtship behavior.
Key words:
CaM kinase II;
Drosophila;
courtship
conditioning;
memory;
learning;
visual mutants;
transgenes
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