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Previous Article | Next Article
Volume 17, Number 24, Issue of December 15, 1997 pp. 9423-9432
Identification of Two Nervous System-Specific Members of the erg Potassium Channel Gene Family
Received Aug. 18, 1997; revised Sept. 25, 1997; accepted Sept. 26, 1997.
Wenmei Shi1, Randy S. Wymore2, Hong-Sheng Wang2, Zongming Pan1, Ira S. Cohen1, David McKinnon1, 2, and Jane E. Dixon1 1 Departments of Neurobiology and Behavior and 2 Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York 11794
Two new potassium channel genes, erg2 and erg3, that are expressed in the nervous system of the rat were identified. These two genes form a small gene family with the previously described erg1 (HERG) gene. The erg2 and erg3 genes are expressed exclusively in the nervous system, in marked contrast to erg1, which is expressed in both neural and non-neural tissues. All three genes are expressed in peripheral sympathetic ganglia. The erg3 channel produces a current that has a large transient component at positive potentials, whereas the other two channels are slowly activating delayed rectifiers. Expression of the erg1 gene in the sympathetic nervous system has potential implications for the etiology of the LQT2 form of the human genetic disease long QT syndrome.
Key words: potassium channel; erg; long QT syndrome; sympathetic neuron; gene; delayed rectifier
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