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Volume 17, Number 24, Issue of December 15, 1997 pp. 9746-9750

Effects of Sleep on Wake-Induced c-fos Expression

Received Aug. 11, 1997; revised Oct. 1, 1997; accepted Oct. 7, 1997.

Radhika Basheer¹, Jonathan E. Sherin², Clifford B. Saper², James I. Morgan³, Robert W. McCarley¹, and Priyattam J. Shiromani¹

¹ VA Medical Center and Harvard Medical School, Brockton, Massachusetts 02401, ² Department of Neurology, Beth Israel-Deaconess Hospital, Boston, Massachusetts 02215, and ³ Department of Developmental Neurobiology, St. Jude Children Research Hospital, Memphis, Tennessee 38105

We investigated the effects of sleep on wake-induced c-fos expression in the cerebral cortex of rats and c-fos-lacZ transgenic mice. In the cortex of rats, the levels of c-Fos, detected both by immunocytochemistry and Western blot, remained high during 6 or 12 hr of enforced wakefulness but declined rapidly (within 1 hr) with increasing time of recovery sleep. Similarly, in the transgenic mice in which lacZ expression is driven from the c-fos promoter, -galactosidase activity was high after enforced wakefulness and declined with increasing amounts of sleep. These results suggest that the decrease in c-Fos protein in cortical neurons during sleep may be attributable to cessation of c-fos expression, activation of a process that degrades the wake-induced c-Fos, or both.

Key words: sleep; c-fos expression; c-fos-lacZ transgenic mice; cingulate cortex; immunohistochemistry; Western blot; -gal activity

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