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Next Article 
Volume 17, Number 3,
Issue of February 1, 1997
pp. 875-881
Copyright ©1997 Society for Neuroscience
The Drosophila erg K+ Channel Polypeptide
Is Encoded by the Seizure Locus
Received July 7, 1996; revised Oct. 22, 1996; accepted Oct. 24, 1996.
Steven A. Titus,
Jeffrey W. Warmke, and
Barry Ganetzky
Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin
53706
The eag family of K+ channels contains
three known subtypes: eag, elk, and
erg. Genes representing the first two subtypes have been
identified in flies and mammals, whereas the third subtype has been
defined only by the human HERG gene, which encodes an inwardly
rectifying channel that is mutated in some cardiac arrhythmias. To
establish the predicted existence of a Drosophila gene
in the erg subfamily and to learn more about the
structure and biological function of channels within this subfamily, we
undertook a search for the Drosophila counterpart of
HERG. Here we report the isolation and characterization of the
Drosophila erg gene. We show that it corresponds with
the previously identified seizure (sei) locus, mutations of which cause a temperature-sensitive paralytic phenotype associated with hyperactivity in the flight motor pathway. These results yield new insights into the structure and evolution of the
eag family of channels, provide a molecular explanation
for the sei mutant phenotype, and demonstrate the
important physiological roles of erg-type channels from
invertebrates to mammals.
Key words:
K+ channels;
eag family;
seizure mutation;
neurogenetics;
LQT syndrome;
HERG
channels;
hyperexcitability
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