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Volume 17, Number 4, Issue of February 15, 1997 pp. 1435-1446
Copyright ©1997 Society for Neuroscience

A Pacemaker Current in Dye-Coupled Hilar Interneurons Contributes to the Generation of Giant GABAergic Potentials in Developing Hippocampus

Received June 27, 1996; revised Nov. 14, 1996; accepted Nov. 22, 1996.

Fabrizio Strata¹, Marco Atzori¹, Margherita Molnar¹, Gabriele Ugolini¹, Filippo Tempia², and Enrico Cherubini¹

¹ Biophysics Laboratory, International School for Advanced Studies (SISSA), 34014 Trieste, Italy, and ² Department of Neuroscience, University of Torino, 10125 Torino, Italy

The establishment of synaptic connections and their refinement during development require neural activity. Increasing evidence suggests that spontaneous bursts of neural activity within an immature network are mediated by -aminobutyric acid via a paradoxical excitatory action. Our data show that in the developing hippocampus such synchronous burst activity is generated in the hilar region by transiently coupled cells. These cells have been identified as neuronal elements because they fire action potentials and they are not positive for the glial fibrillary acidic protein staining. Oscillations in hilar cells are "paced" by a hyperpolarization-activated current, with properties of I_h. Coactivated interneurons synchronously release GABA, which via its excitatory action may serve a neurotrophic function during the refinement of hippocampal circuitry.

Key words: GABA; giant GABAergic potentials; bursting activity; development; hippocampus; pacemaker; inward rectifier current

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