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Volume 17, Number 5, Issue of March 1, 1997 pp. 1691-1700
Copyright ©1997 Society for NeuroscienceDendritic and Postsynaptic Localizations of Glycine Receptor
Subunit mRNAs
Received Oct. 1, 1996; revised Dec. 16, 1996; accepted Dec. 18, 1996.
Claudia Racca, Alejandra Gardiol, and Antoine Triller Laboratoire de Biologie Cellulaire de la Synapse, INSERM, CJF 94-10, Ecole Normale Supérieure, 75005 Paris, France
Some synaptic neurotransmitter receptors, such as those for glycine, have somato-dendritic distributions. Although the machinery for protein synthesis and several mRNAs are present in dendrites and close to synapses in central neurons, so far the mRNAs for neurotransmitter receptors have not been found unequivocally in dendrites. The glycine receptor (GlyR), a ligand-gated channel mediating a chloride-dependent inhibition, is composed of transmembrane
and
subunits. GlyRs are only present at glycinergic postsynaptic differentiation, where they are stabilized by the associated protein gephyrin. With light nonradioactive in situ hybridization (ISH), we observe that GlyR
Key words: glycine receptor; dendritic mRNA; spinal cord; in situ hybridization; immunocytochemistry; confocal microscopy; electron microscopy
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