 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
Volume 17, Number 6, Issue of March 15, 1997 pp. 1981-1992
Copyright ©1997 Society for NeuroscienceMechanism Involved in Initiation and Propagation of Receptor-Induced Intercellular Calcium Signaling in Cultured Rat Astrocytes
Received Sept. 5, 1996; revised Nov. 21, 1996; accepted Dec. 23, 1996.
Laurent Venance, Nephi Stella, Jacques Glowinski, and Christian Giaume Institut National de la Santé et de la Recherche Médicale, U114, Collège de France, 75231 Paris, Cedex 05, France
The mechanisms involved in the initiation and the propagation of intercellular calcium signaling (calcium waves) were studied in cultured rat astrocytes. The analysis of calcium waves, induced either by mechanical stimulation or by focal application of ionomycin, indicated that initiation was dependent on the presence of external calcium. In addition, pharmacological experiments indicate that intercellular propagation required PLC activation, integrity of IP3-sensitive internal calcium stores, and functional gap junctions. An extracellular action of ATP or glutamate and participation of voltage-dependent Ca2+ channels were tested by using enzymatic degradation, receptor antagonists, and channel blockers, respectively. Because neither the speed of propagation nor the extent of the calcium waves was affected by these treatments, these alternate mechanisms were excluded from playing a role in intercellular calcium signaling. Biochemical assays and focal applications of several agonists (methoxamine, carbachol, glutamate) of membrane receptors to neurotransmitters and peptides (endothelin 1) demonstrated that their ability to trigger regenerative calcium waves depended on phospholipase C activity and inositol phosphate production. Thus, in rat astrocytes, initiation and propagation of calcium waves involve a sequence of intra- and intercellular steps in which phospholipase C, inositol trisphosphate, internal calcium stores, and gap junction channels play a critical role. The identification of these different events allows us to determine several targets at which the level of long-range signaling in astrocytes may be controlled.
Key words: intercellular calcium waves; glial cells; gap junctions; phospholipase C; IP3 receptors; internal calcium stores; U-73122
This article has been cited by other articles:
Z. L. Kurth-Nelson, A. Mishra, and E. A. Newman
Spontaneous Glial Calcium Waves in the Retina Develop over Early Adulthood
J. Neurosci., September 9, 2009; 29(36): 11339 - 11346.
[Abstract] [Full Text] [PDF]
J Miguel-Hidalgo, Y Shoyama, and V Wanzo
Infusion of gliotoxins or a gap junction blocker in the prelimbic cortex increases alcohol preference in Wistar rats
J Psychopharmacol, July 1, 2009; 23(5): 550 - 557.
[Abstract] [PDF]
E. Yeh, T. Kawano, S. Ng, R. Fetter, W. Hung, Y. Wang, and M. Zhen
Caenorhabditis elegans Innexins Regulate Active Zone Differentiation
J. Neurosci., April 22, 2009; 29(16): 5207 - 5217.
[Abstract] [Full Text] [PDF]
P. G. Haydon and G. Carmignoto
Astrocyte control of synaptic transmission and neurovascular coupling.
Physiol Rev, July 1, 2006; 86(3): 1009 - 1031.
[Abstract] [Full Text] [PDF]
M. T. Barbe, H. Monyer, and R. Bruzzone
Cell-Cell Communication Beyond Connexins: The Pannexin Channels
Physiology, April 1, 2006; 21(2): 103 - 114.
[Abstract] [Full Text] [PDF]
Y. Bernardinelli, P. J. Magistretti, and J.-Y. Chatton
Astrocytes generate Na+-mediated metabolic waves
PNAS, October 12, 2004; 101(41): 14937 - 14942.
[Abstract] [Full Text] [PDF]
J. Kleeberg, G. C. Petzold, S. Major, U. Dirnagl, and J. P. Dreier
ET-1 induces cortical spreading depression via activation of the ETA receptor/phospholipase C pathway in vivo
Am J Physiol Heart Circ Physiol, April 1, 2004; 286(4): H1339 - H1346.
[Abstract] [Full Text] [PDF]
N. Li, J.-Y. Sul, and P. G. Haydon
A Calcium-Induced Calcium Influx Factor, Nitric Oxide, Modulates the Refilling of Calcium Stores in Astrocytes
J. Neurosci., November 12, 2003; 23(32): 10302 - 10310.
[Abstract] [Full Text] [PDF]
C. J. Gallagher and M. W. Salter
Differential Properties of Astrocyte Calcium Waves Mediated by P2Y1 and P2Y2 Receptors
J. Neurosci., July 30, 2003; 23(17): 6728 - 6739.
[Abstract] [Full Text] [PDF]
F. Aguado, J. F. Espinosa-Parrilla, M. A. Carmona, and E. Soriano
Neuronal Activity Regulates Correlated Network Properties of Spontaneous Calcium Transients in Astrocytes In Situ
J. Neurosci., November 1, 2002; 22(21): 9430 - 9444.
[Abstract] [Full Text] [PDF]
T. Hofer, L. Venance, and C. Giaume
Control and Plasticity of Intercellular Calcium Waves in Astrocytes: A Modeling Approach
J. Neurosci., June 15, 2002; 22(12): 4850 - 4859.
[Abstract] [Full Text] [PDF]
J. P. Dreier, J. Kleeberg, G. Petzold, J. Priller, O. Windmuller, H.-D. Orzechowski, U. Lindauer, U. Heinemann, K. M. Einhaupl, and U. Dirnagl
Endothelin-1 potently induces Leao's cortical spreading depression in vivo in the rat: A model for an endothelial trigger of migrainous aura?
Brain, January 1, 2002; 125(1): 102 - 112.
[Abstract] [Full Text] [PDF]
J. Leonova, T. Thorlin, N. D. Aberg, P. S. Eriksson, L. Ronnback, and E. Hansson
Endothelin-1 decreases glutamate uptake in primary cultured rat astrocytes
Am J Physiol Cell Physiol, November 1, 2001; 281(5): C1495 - C1503.
[Abstract] [Full Text] [PDF]
R. Bychkov, J. Glowinski, and C. Giaume
Sequential and opposite regulation of two outward K+ currents by ET-1 in cultured striatal astrocytes
Am J Physiol Cell Physiol, October 1, 2001; 281(4): C1373 - C1384.
[Abstract] [Full Text] [PDF]
L. Lagostena, J. F Ashmore, B. Kachar, and F. Mammano
Purinergic control of intercellular communication between Hensen's cells of the guinea-pig cochlea
J. Physiol., March 15, 2001; 531(3): 693 - 706.
[Abstract] [Full Text] [PDF]
V. E. Klepeis, A. Cornell-Bell, and V. Trinkaus-Randall
Growth factors but not gap junctions play a role in injury-induced Ca2+ waves in epithelial cells
J. Cell Sci., January 12, 2001; 114(23): 4185 - 4195.
[Abstract] [Full Text] [PDF]
S. Boitano and W. H. Evans
Connexin mimetic peptides reversibly inhibit Ca2+ signaling through gap junctions in airway cells
Am J Physiol Lung Cell Mol Physiol, October 1, 2000; 279(4): L623 - L630.
[Abstract] [Full Text] [PDF]
N. Rouach, J. Glowinski, and C. Giaume
Activity-Dependent Neuronal Control of Gap-Junctional Communication in Astrocytes
J. Cell Biol., June 26, 2000; 149(7): 1513 - 1526.
[Abstract] [Full Text] [PDF]
K. Paemeleire, P. E. M. Martin, S. L. Coleman, K. E. Fogarty, W. A. Carrington, L. Leybaert, R. A. Tuft, W. H. Evans, and M. J. Sanderson
Intercellular Calcium Waves in HeLa Cells Expressing GFP-labeled Connexin 43, 32, or 26
Mol. Biol. Cell, May 1, 2000; 11(5): 1815 - 1827.
[Abstract] [Full Text]
M. L. Cotrina and M. Nedergaard
ATP as a Messenger in Astrocyte-Neuronal Communication
Neuroscientist, April 1, 2000; 6(2): 120 - 126.
[Abstract] [PDF]
N. J. Willmott, K. Wong, and A. J. Strong
A Fundamental Role for the Nitric Oxide-G-Kinase Signaling Pathway in Mediating Intercellular Ca2+ Waves in Glia
J. Neurosci., March 1, 2000; 20(5): 1767 - 1779.
[Abstract] [Full Text] [PDF]
E. Scemes, S. O. Suadicani, and D. C. Spray
Intercellular Communication in Spinal Cord Astrocytes: Fine Tuning between Gap Junctions and P2 Nucleotide Receptors in Calcium Wave Propagation
J. Neurosci., February 15, 2000; 20(4): 1435 - 1445.
[Abstract] [Full Text] [PDF]
G. DUPONT, T. TORDJMANN, C. CLAIR, S. SWILLENS, M. CLARET, and L. COMBETTES
Mechanism of receptor-oriented intercellular calcium wave propagation in hepatocytes
FASEB J, February 1, 2000; 14(2): 279 - 289.
[Abstract] [Full Text]
E. Boitier, R. Rea, and M. R. Duchen
Mitochondria Exert a Negative Feedback on the Propagation of Intracellular Ca2+ Waves in Rat Cortical Astrocytes
J. Cell Biol., May 17, 1999; 145(4): 795 - 808.
[Abstract] [Full Text] [PDF]
P. B. Guthrie, J. Knappenberger, M. Segal, M. V. L. Bennett, A. C. Charles, and S. B. Kater
ATP Released from Astrocytes Mediates Glial Calcium Waves
J. Neurosci., January 15, 1999; 19(2): 520 - 528.
[Abstract] [Full Text] [PDF]
M. L. Cotrina, J. H.-C. Lin, A. Alves-Rodrigues, S. Liu, J. Li, H. Azmi-Ghadimi, J. Kang, C. C. G. Naus, and M. Nedergaard
Connexins regulate calcium signaling by controlling ATP release
PNAS, December 22, 1998; 95(26): 15735 - 15740.
[Abstract] [Full Text] [PDF]
M. L. Cotrina, J. H.-C. Lin, and M. Nedergaard
Cytoskeletal Assembly and ATP Release Regulate Astrocytic Calcium Signaling
J. Neurosci., November 1, 1998; 18(21): 8794 - 8804.
[Abstract] [Full Text] [PDF]
T. A. Basarsky, S. N. Duffy, R. D. Andrew, and B. A. MacVicar
Imaging Spreading Depression and Associated Intracellular Calcium Waves in Brain Slices
J. Neurosci., September 15, 1998; 18(18): 7189 - 7199.
[Abstract] [Full Text] [PDF]
L. Venance, J. Premont, J. Glowinski, and C. Giaume
Gap junctional communication and pharmacological heterogeneity in astrocytes cultured from the rat striatum
J. Physiol., July 15, 1998; 510(2): 429 - 440.
[Abstract] [Full Text] [PDF]
A. VERKHRATSKY, R. K. ORKAND, and H. KETTENMANN
Glial Calcium: Homeostasis and Signaling Function
Physiol Rev, January 1, 1998; 78(1): 99 - 141.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|