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Next Article 
Volume 17, Number 7,
Issue of April 1, 1997
pp. 2247-2256
Copyright ©1997 Society for Neuroscience
Intercircuit Control of Motor Pattern Modulation by
Presynaptic Inhibition
Received Dec. 5, 1996; accepted Dec. 24, 1996.
Marlene Bartos and
Michael P. Nusbaum
Department of Neuroscience, University of Pennsylvania School of
Medicine, Philadelphia, Pennsylvania 19104
Rhythmically active neural networks can control the modulatory
input that they receive via their synaptic effects onto modulatory neurons. This synaptic control of network modulation can occur presynaptically, at the axon terminals of the modulatory neuron. For
example, in the crab stomatogastric ganglion (STG), a gastric mill
network neuron presynaptically inhibits transmitter release from a
modulatory projection neuron called modulatory commissural neuron 1. We
showed previously that the gastric mill rhythm-timed presynaptic
inhibition of the STG terminals of MCN1 is pivotal for enabling MCN1 to
activate this rhythm. We also showed that MCN1 excites the pyloric
rhythm within the STG. Here we show that, because MCN1 stimulation
conjointly excites the gastric mill and pyloric rhythms, the gastric
mill rhythm-timed presynaptic inhibition of MCN1 causes a rhythmic
interruption in the MCN1-mediated excitation of the pyloric rhythm.
Consequently, during each protraction phase of the gastric mill rhythm,
presynaptic inhibition suppresses MCN1 excitation of the pyloric
rhythm, thereby weakening the pyloric rhythm. During the retraction
phase, presynaptic inhibition is absent and MCN1 elicits a faster,
stronger, and modified pyloric rhythm. Thus, in addition to its role in
enabling a neural circuit to regulate the modulatory transmission that
it receives, presynaptic inhibition is also used effectively to
rhythmically control the activity level of a distinct, but behaviorally
related, neural circuit.
Key words:
presynaptic inhibition;
pyloric rhythm;
gastric mill
rhythm;
Cancer borealis;
stomatogastric nervous system;
neuromodulation
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