QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (60) Citing Articles via Google Scholar Google Scholar Articles by Segal, D. S. Articles by Kuczenski, R. Search for Related Content PubMed PubMed Citation Articles by Segal, D. S. Articles by Kuczenski, R.

 Previous Article  |  Next Article 

Volume 17, Number 7, Issue of April 1, 1997 pp. 2551-2566
Copyright ©1997 Society for Neuroscience

An Escalating Dose "Binge" Model of Amphetamine Psychosis: Behavioral and Neurochemical Characteristics

Received Aug. 6, 1996; revised Dec. 4, 1996; accepted Dec. 6, 1996.

David S. Segal and Ronald Kuczenski

Psychiatry Department, University of California, San Diego, School of Medicine, La Jolla, California 92093

Stimulant-induced psychosis is most frequently associated with a chronic, high-dose, multiple daily ("binge") exposure pattern of stimulant abuse. To simulate these conditions, rats were exposed to escalating doses of amphetamine (Escalating Dose phase, 1.0-8.0 mg/kg) before multiple daily injections of relatively high doses of the drug (Run phase, 8.0 mg/kg/2 hr × 4 injections). Behavior was monitored continuously during the course of these treatments as well as during subsequent amphetamine challenges at various times after discontinuation of drug treatment. With the Escalating Dose-Run pattern of administration, a unique behavioral profile emerged in which tolerance occurred to the amount of time spent engaged in continuous focused stereotypy simultaneous with a profound increase in ambulatory activity that appeared agitated and disorganized. Parallel in vivo microdialysis studies showed progressively declining extracellular dopamine and serotonin responses, both within and between successive runs, whereas the norepinephrine response remained relatively unaltered. We propose that this model more closely resembles clinical manifestations of amphetamine psychosis and that the alterations may reflect a shift in the relative activation of mesolimbic and nigro-striatal dopamine pathways.

Key words: amphetamine; stereotypy; locomotion; binge; psychosis; microdialysis; dopamine; norepinephrine; serotonin

This article has been cited by other articles:

				A. W. MacDonald and S. C. Schulz What We Know: Findings That Every Theory of Schizophrenia Should Explain Schizophr Bull, May 1, 2009; 35(3): 493 - 508. [Abstract] [Full Text] [PDF]

				D. S. Segal and R. Kuczenski Escalating Dose-Binge Treatment with Methylphenidate: Role of Serotonin in the Emergent Behavioral Profile J. Pharmacol. Exp. Ther., October 1, 1999; 291(1): 19 - 30. [Abstract] [Full Text]

				Y. Itzhak, C. Gandia, P. L. Huang, and S. F. Ali Resistance of Neuronal Nitric Oxide Synthase-Deficient Mice to Methamphetamine-Induced Dopaminergic Neurotoxicity J. Pharmacol. Exp. Ther., March 1, 1998; 284(3): 1040 - 1047. [Abstract] [Full Text]

				D. S. Segal and R. Kuczenski Repeated Binge Exposures to Amphetamine and Methamphetamine: Behavioral and Neurochemical Characterization J. Pharmacol. Exp. Ther., August 1, 1997; 282(2): 561 - 573. [Abstract] [Full Text]

				R. Kuczenski and D. S. Segal An Escalating Dose/Multiple High-Dose Binge Pattern of Amphetamine Administration Results in Differential Changes in the Extracellular Dopamine Response Profiles in Caudate-Putamen and Nucleus Accumbens J. Neurosci., June 1, 1997; 17(11): 4441 - 4447. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help