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Volume 17, Number 8, Issue of April 15, 1997 pp. 2900-2913
Copyright ©1997 Society for Neuroscience

A Simplified Preparation for Relating Cellular Events to Behavior: Contribution of LE and Unidentified Siphon Sensory Neurons to Mediation and Habituation of the Aplysia Gill- and Siphon-Withdrawal Reflex

Received Sept. 20, 1996; revised Jan. 2, 1997; accepted Jan. 31, 1997.

Lina Frost¹, Saul W. Kaplan¹, Tracey E. Cohen¹, Victor Henzi¹, Eric R. Kandel^{1, 2, 3}, and Robert D. Hawkins^{1, 2}

¹ Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, ² New York State Psychiatric Institute, and ³ Howard Hughes Medical Institute, New York, New York 10032

We have begun to analyze several elementary forms of learning in a simple preparation consisting of the isolated mantle organs and abdominal ganglion of Aplysia. Previous studies suggested that plasticity at siphon sensory neuron synapses contributes to habituation and dishabituation of the gill- and siphon-withdrawal reflex in this preparation. We next wished to identify the sensory neurons that participate in the reflex and examine their plasticity more directly. To investigate the contribution of the LE siphon mechanosensory cells, we recorded from them and gill or siphon motor neurons during the same siphon stimulation that has been used in behavioral experiments in this preparation. Our results indicate that the LE cells make a substantial contribution to the evoked response in the motor neurons under these conditions, but they suggest that other as yet unidentified siphon sensory neurons with lower thresholds and shorter latencies also contribute. In addition, we find that homosynaptic depression of monosynaptic postsynaptic potentials (PSPs) from LE sensory cells makes an important contribution to habituation of the response in the motor neurons. To investigate plasticity of PSPs from the unidentified sensory neurons, we recorded the PSP that was produced in a motor neuron by water-movement stimulation of the siphon, which does not cause firing of LE cells. Our results suggest that PSPs from the unidentified sensory neurons and the LE neurons undergo similar plasticity during habituation and dishabituation training. These results support the idea that plasticity at synapses of both LE and unidentified sensory neurons contributes to habituation and dishabituation of the reflex response in this preparation.

Key words: Aplysia; gill-withdrawal reflex; siphon; sensory neurons; latency; threshold; habituation; dishabituation; learning

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