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Volume 17, Number 8, Issue of April 15, 1997 pp. 2914-2920
Copyright ©1997 Society for NeuroscienceResponse Variability of Neurons in Primary Visual Cortex (V1) of Alert Monkeys
Received Nov. 19, 1996; revised Feb. 3, 1997; accepted Feb. 5, 1997.
Moshe Gur1, 2, Alexander Beylin1, and D. Max Snodderly2, 3 1 Department of Biomedical Engineering, Technion, Israel Institute of Technology, Haifa 32000, Israel, 2 Schepens Eye Research Institute, Boston, Massachusetts 02114, and 3 Department of Ophthalmology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115
Response variability of neurons limits the reliability and resolution of sensory systems. It is generally thought that response variability in the visual system increases at cortical levels, but the causes of the variability have not been identified. We have measured the response variability of neurons in primary visual cortex (V1) of alert monkeys. We recorded from 80 single cells distributed over all V1 layers and from 8 parvocellular cells of the lateral geniculate nucleus. All cells were stimulated with a bar of near-optimal orientation, color, and dimensions while continuously monitoring the eye movements of fixation. To minimize the effects of eye movements, responses that occurred while the eye was relatively steady were selected for analysis. The impulses elicited by each stimulus presentation were counted, and the variance and coefficient of variation were computed. Both measures of response variability were much lower than reported previously for V1 cells of both alert and anesthetized monkeys. Our data show that fixational eye movements cause a large component of response variance in alert monkeys. Moreover, the reliability of V1 neurons is not obviously degraded compared with lateral geniculate nucleus cells. The high reliability of neurons in alert monkeys is consistent with expectations from conventional biophysical models, and it suggests that activity in a modest number of neurons may suffice to form a perceptual decision.
Key words: striate cortex; monkey; alert; single cells; response variability; vision
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