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The Journal of Neuroscience, January 1, 1998, 18(1):237-250
Sox10, a Novel Transcriptional Modulator in Glial Cells
Kirsten
Kuhlbrodt,
Beate
Herbarth,
Elisabeth
Sock,
Irm
Hermans-Borgmeyer, and
Michael
Wegner
Zentrum für Molekulare Neurobiologie, Universität
Hamburg, D-20246 Hamburg, Germany
Sox proteins are characterized by possession of a DNA-binding
domain with similarity to the high-mobility group domain of the sex
determining factor SRY. Here, we report on Sox10, a novel protein with
predominant expression in glial cells of the nervous system. During
development Sox10 first appeared in the forming neural crest and
continued to be expressed as these cells contributed to the forming PNS
and finally differentiated into Schwann cells. In the CNS, Sox10
transcripts were originally confined to glial precursors and later
detected in oligodendrocytes of the adult brain. Functional studies
failed to reveal autonomous transcriptional activity for Sox10.
Instead, Sox10 functioned synergistically with the POU domain protein
Tst-1/Oct6/SCIP with which it is coexpressed during certain stages of
Schwann cell development. Synergy depended on binding to adjacent sites
in target promoters, was mediated by the N-terminal regions of both
proteins, and could not be observed between Sox10 and several other POU
domain proteins. Interestingly, Sox10 also modulated the function of
Pax3 and Krox-20, two other transcription factors involved in Schwann
cell development. We propose a role for Sox10 in conferring cell
specificity to the function of other transcription factors in
developing and mature glia.
Key words:
POU; Sox; synergy; neural crest; Schwann cell; oligodendrocyte
Copyright © 1998 Society for Neuroscience 0270-6474/98/181237-14$05.00/0
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H. M. Young, B. R. Jones, and S. J. McKeown
The Projections of Early Enteric Neurons Are Influenced by the Direction of Neural Crest Cell Migration
J. Neurosci.,
July 15, 2002;
22(14):
6005 - 6018.
[Abstract]
[Full Text]
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M. Zirlinger, L. Lo, J. McMahon, A. P. McMahon, and D. J. Anderson
Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate
PNAS,
June 11, 2002;
99(12):
8084 - 8089.
[Abstract]
[Full Text]
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H. T. Khong and S. A. Rosenberg
The Waardenburg Syndrome Type 4 Gene, SOX10, Is a Novel Tumor-associated Antigen Identified in a Patient with a Dramatic Response to Immunotherapy
Cancer Res.,
June 1, 2002;
62(11):
3020 - 3023.
[Abstract]
[Full Text]
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A. K. Kamaraju, C. Bertolotto, J. Chebath, and M. Revel
Pax3 Down-regulation and Shut-off of Melanogenesis in Melanoma B16/F10.9 by Interleukin-6 Receptor Signaling
J. Biol. Chem.,
April 19, 2002;
277(17):
15132 - 15141.
[Abstract]
[Full Text]
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C. C. Stolt, S. Rehberg, M. Ader, P. Lommes, D. Riethmacher, M. Schachner, U. Bartsch, and M. Wegner
Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10
Genes & Dev.,
January 15, 2002;
16(2):
165 - 170.
[Abstract]
[Full Text]
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L. Lo, E. Dormand, A. Greenwood, and D. J. Anderson
Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells
Development,
January 4, 2002;
129(7):
1553 - 1567.
[Abstract]
[Full Text]
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H. Fu, Y. Qi, M. Tan, J. Cai, H. Takebayashi, M. Nakafuku, W. Richardson, and M. Qiu
Dual origin of spinal oligodendrocyte progenitors and evidence for the cooperative role of Olig2 and Nkx2.2 in the control of oligodendrocyte differentiation
Development,
January 2, 2002;
129(3):
681 - 693.
[Abstract]
[Full Text]
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N. Bondurand, M. Girard, V. Pingault, N. Lemort, O. Dubourg, and M. Goossens
Human Connexin 32, a gap junction protein altered in the X-linked form of Charcot-Marie-Tooth disease, is directly regulated by the transcription factor SOX10
Hum. Mol. Genet.,
November 1, 2001;
10(24):
2783 - 2795.
[Abstract]
[Full Text]
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K. A. Dutton, A. Pauliny, S. S. Lopes, S. Elworthy, T. J. Carney, J. Rauch, R. Geisler, P. Haffter, and R. N. Kelsh
Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates
Development,
November 1, 2001;
128(21):
4113 - 4125.
[Abstract]
[Full Text]
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E. Sock, K. Schmidt, I. Hermanns-Borgmeyer, M. R. Bosl, and M. Wegner
Idiopathic Weight Reduction in Mice Deficient in the High-Mobility-Group Transcription Factor Sox8
Mol. Cell. Biol.,
October 15, 2001;
21(20):
6951 - 6959.
[Abstract]
[Full Text]
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C. Paratore, D. E. Goerich, U. Suter, M. Wegner, and L. Sommer
Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox10 and extrinsic combinatorial signaling
Development,
October 15, 2001;
128(20):
3949 - 3961.
[Abstract]
[Full Text]
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M H Sham, V C H Lui, M Fu, B Chen, and P K H Tam
SOX10 is abnormally expressed in aganglionic bowel of Hirschsprung's disease infants
Gut,
August 1, 2001;
49(2):
220 - 226.
[Abstract]
[Full Text]
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A. Gavalas, P. Trainor, L. Ariza-McNaughton, and R. Krumlauf
Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crest
Development,
August 1, 2001;
128(15):
3017 - 3027.
[Abstract]
[Full Text]
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N. Tekki-Kessaris, R. Woodruff, A. C. Hall, W. Gaffield, S. Kimura, C. D. Stiles, D. H. Rowitch, and W. D. Richardson
Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon
Development,
July 1, 2001;
128(13):
2545 - 2554.
[Abstract]
[Full Text]
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B. Andersen and M. G. Rosenfeld
POU Domain Factors in the Neuroendocrine System: Lessons from Developmental Biology Provide Insights into Human Disease
Endocr. Rev.,
February 1, 2001;
22(1):
2 - 35.
[Abstract]
[Full Text]
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S. Britsch, D. E. Goerich, D. Riethmacher, R. I. Peirano, M. Rossner, K.-A. Nave, C. Birchmeier, and M. Wegner
The transcription factor Sox10 is a key regulator of peripheral glial development
Genes & Dev.,
January 1, 2001;
15(1):
66 - 78.
[Abstract]
[Full Text]
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D. Pennisi, J. Bowles, A. Nagy, G. Muscat, and P. Koopman
Mice Null for Sox18 Are Viable and Display a Mild Coat Defect
Mol. Cell. Biol.,
December 15, 2000;
20(24):
9331 - 9336.
[Abstract]
[Full Text]
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R. I. Peirano and M. Wegner
The glial transcription factor Sox10 binds to DNA both as monomer and dimer with different functional consequences
Nucleic Acids Res.,
August 15, 2000;
28(16):
3047 - 3055.
[Abstract]
[Full Text]
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N. Bondurand, V. Pingault, D. E. Goerich, N. Lemort, E. Sock, C. L. Caignec, M. Wegner, and M. Goossens
Interaction among SOX10, PAX3 and MITF, three genes altered in Waardenburg syndrome
Hum. Mol. Genet.,
August 12, 2000;
9(13):
1907 - 1917.
[Abstract]
[Full Text]
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C. R. Goding
Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage
Genes & Dev.,
July 15, 2000;
14(14):
1712 - 1728.
[Full Text]
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R. I. Peirano, D. E. Goerich, D. Riethmacher, and M. Wegner
Protein Zero Gene Expression Is Regulated by the Glial Transcription Factor Sox10
Mol. Cell. Biol.,
May 1, 2000;
20(9):
3198 - 3209.
[Abstract]
[Full Text]
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G. E. Schepers, M. Bullejos, B. M. Hosking, and P. Koopman
Cloning and characterisation of the Sry-related transcription factor gene Sox8
Nucleic Acids Res.,
March 15, 2000;
28(6):
1473 - 1480.
[Abstract]
[Full Text]
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T. K. Nowling, L. R. Johnson, M. S. Wiebe, and A. Rizzino
Identification of the Transactivation Domain of the Transcription Factor Sox-2 and an Associated Co-activator
J. Biol. Chem.,
February 11, 2000;
275(6):
3810 - 3818.
[Abstract]
[Full Text]
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N Koyano-Nakagawa, J Kim, D Anderson, and C Kintner
Hes6 acts in a positive feedback loop with the neurogenins to promote neuronal differentiation
Development,
January 10, 2000;
127(19):
4203 - 4216.
[Abstract]
[PDF]
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M. Howard, M Stanke, C Schneider, X Wu, and H Rohrer
The transcription factor dHAND is a downstream effector of BMPs in sympathetic neuron specification
Development,
January 9, 2000;
127(18):
4073 - 4081.
[Abstract]
[PDF]
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Y Wakamatsu, T. Maynard, and J. Weston
Fate determination of neural crest cells by NOTCH-mediated lateral inhibition and asymmetrical cell division during gangliogenesis
Development,
January 7, 2000;
127(13):
2811 - 2821.
[Abstract]
[PDF]
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Q. Liu, I. N. Melnikova, M. Hu, and P. D. Gardner
Cell Type-Specific Activation of Neuronal Nicotinic Acetylcholine Receptor Subunit Genes by Sox10
J. Neurosci.,
November 15, 1999;
19(22):
9747 - 9755.
[Abstract]
[Full Text]
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M.-D. Galibert, U. Yavuzer, T. J. Dexter, and C. R. Goding
Pax3 and Regulation of the Melanocyte-specific Tyrosinase-related Protein-1 Promoter
J. Biol. Chem.,
September 17, 1999;
274(38):
26894 - 26900.
[Abstract]
[Full Text]
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N. Bondurand, K. Kuhlbrodt, V. Pingault, J. Enderich, M. Sajus, N. Tommerup, M. Warburg, R. C. M. Hennekam, A. P. Read, M. Wegner, et al.
A molecular analysis of the Yemenite deaf-blind hypopigmentation syndrome: SOX10 dysfunction causes different neurocristopathies
Hum. Mol. Genet.,
September 1, 1999;
8(9):
1785 - 1789.
[Abstract]
[Full Text]
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E. Sock, J. Enderich, and M. Wegner
The J Domain of Papovaviral Large Tumor Antigen Is Required for Synergistic Interaction with the POU-Domain Protein Tst-1/Oct6/SCIP
Mol. Cell. Biol.,
April 1, 1999;
19(4):
2455 - 2464.
[Abstract]
[Full Text]
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E. M. Southard-Smith, M. Angrist, J. S. Ellison, R. Agarwala, A. D. Baxevanis, A. Chakravarti, and W. J. Pavan
The Sox10Dom Mouse: Modeling the Genetic Variation of Waardenburg-Shah (WS4) Syndrome
Genome Res.,
March 1, 1999;
9(3):
215 - 225.
[Abstract]
[Full Text]
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D. A. Kenny, L. W. Jurata, Y. Saga, and G. N. Gill
Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis
PNAS,
September 15, 1998;
95(19):
11257 - 11262.
[Abstract]
[Full Text]
[PDF]
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K. Kuhlbrodt, C. Schmidt, E. Sock, V. Pingault, N. Bondurand, M. Goossens, and M. Wegner
Functional Analysis of Sox10 Mutations Found in Human Waardenburg-Hirschsprung Patients
J. Biol. Chem.,
September 4, 1998;
273(36):
23033 - 23038.
[Abstract]
[Full Text]
[PDF]
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K. Kuhlbrodt, B. Herbarth, E. Sock, J. Enderich, I. Hermans-Borgmeyer, and M. Wegner
Cooperative Function of POU Proteins and SOX Proteins in Glial Cells
J. Biol. Chem.,
June 26, 1998;
273(26):
16050 - 16057.
[Abstract]
[Full Text]
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B. Herbarth, V. Pingault, N. Bondurand, K. Kuhlbrodt, I. Hermans-Borgmeyer, A. Puliti, N. Lemort, M. Goossens, and M. Wegner
Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease
PNAS,
April 28, 1998;
95(9):
5161 - 5165.
[Abstract]
[Full Text]
[PDF]
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