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Previous Article | Next Article
The Journal of Neuroscience, January 1, 1998, 18(1):237-250
Sox10, a Novel Transcriptional Modulator in Glial Cells
Kirsten Kuhlbrodt, Beate Herbarth, Elisabeth Sock, Irm Hermans-Borgmeyer, and Michael Wegner Zentrum für Molekulare Neurobiologie, Universität Hamburg, D-20246 Hamburg, Germany
Sox proteins are characterized by possession of a DNA-binding domain with similarity to the high-mobility group domain of the sex determining factor SRY. Here, we report on Sox10, a novel protein with predominant expression in glial cells of the nervous system. During development Sox10 first appeared in the forming neural crest and continued to be expressed as these cells contributed to the forming PNS and finally differentiated into Schwann cells. In the CNS, Sox10 transcripts were originally confined to glial precursors and later detected in oligodendrocytes of the adult brain. Functional studies failed to reveal autonomous transcriptional activity for Sox10. Instead, Sox10 functioned synergistically with the POU domain protein Tst-1/Oct6/SCIP with which it is coexpressed during certain stages of Schwann cell development. Synergy depended on binding to adjacent sites in target promoters, was mediated by the N-terminal regions of both proteins, and could not be observed between Sox10 and several other POU domain proteins. Interestingly, Sox10 also modulated the function of Pax3 and Krox-20, two other transcription factors involved in Schwann cell development. We propose a role for Sox10 in conferring cell specificity to the function of other transcription factors in developing and mature glia.
Key words: POU; Sox; synergy; neural crest; Schwann cell; oligodendrocyte
Copyright © 1998 Society for Neuroscience 0270-6474/98/181237-14$05.00/0
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G. E. Schepers, M. Bullejos, B. M. Hosking, and P. Koopman
Cloning and characterisation of the Sry-related transcription factor gene Sox8
Nucleic Acids Res., March 15, 2000; 28(6): 1473 - 1480.
[Abstract] [Full Text] [PDF]
T. K. Nowling, L. R. Johnson, M. S. Wiebe, and A. Rizzino
Identification of the Transactivation Domain of the Transcription Factor Sox-2 and an Associated Co-activator
J. Biol. Chem., February 11, 2000; 275(6): 3810 - 3818.
[Abstract] [Full Text] [PDF]
N Koyano-Nakagawa, J Kim, D Anderson, and C Kintner
Hes6 acts in a positive feedback loop with the neurogenins to promote neuronal differentiation
Development, January 10, 2000; 127(19): 4203 - 4216.
[Abstract] [PDF]
M. Howard, M Stanke, C Schneider, X Wu, and H Rohrer
The transcription factor dHAND is a downstream effector of BMPs in sympathetic neuron specification
Development, January 9, 2000; 127(18): 4073 - 4081.
[Abstract] [PDF]
Y Wakamatsu, T. Maynard, and J. Weston
Fate determination of neural crest cells by NOTCH-mediated lateral inhibition and asymmetrical cell division during gangliogenesis
Development, January 7, 2000; 127(13): 2811 - 2821.
[Abstract] [PDF]
Q. Liu, I. N. Melnikova, M. Hu, and P. D. Gardner
Cell Type-Specific Activation of Neuronal Nicotinic Acetylcholine Receptor Subunit Genes by Sox10
J. Neurosci., November 15, 1999; 19(22): 9747 - 9755.
[Abstract] [Full Text] [PDF]
M.-D. Galibert, U. Yavuzer, T. J. Dexter, and C. R. Goding
Pax3 and Regulation of the Melanocyte-specific Tyrosinase-related Protein-1 Promoter
J. Biol. Chem., September 17, 1999; 274(38): 26894 - 26900.
[Abstract] [Full Text] [PDF]
N. Bondurand, K. Kuhlbrodt, V. Pingault, J. Enderich, M. Sajus, N. Tommerup, M. Warburg, R. C. M. Hennekam, A. P. Read, M. Wegner, et al.
A molecular analysis of the Yemenite deaf-blind hypopigmentation syndrome: SOX10 dysfunction causes different neurocristopathies
Hum. Mol. Genet., September 1, 1999; 8(9): 1785 - 1789.
[Abstract] [Full Text] [PDF]
E. Sock, J. Enderich, and M. Wegner
The J Domain of Papovaviral Large Tumor Antigen Is Required for Synergistic Interaction with the POU-Domain Protein Tst-1/Oct6/SCIP
Mol. Cell. Biol., April 1, 1999; 19(4): 2455 - 2464.
[Abstract] [Full Text] [PDF]
E. M. Southard-Smith, M. Angrist, J. S. Ellison, R. Agarwala, A. D. Baxevanis, A. Chakravarti, and W. J. Pavan
The Sox10Dom Mouse: Modeling the Genetic Variation of Waardenburg-Shah (WS4) Syndrome
Genome Res., March 1, 1999; 9(3): 215 - 225.
[Abstract] [Full Text]
D. A. Kenny, L. W. Jurata, Y. Saga, and G. N. Gill
Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis
PNAS, September 15, 1998; 95(19): 11257 - 11262.
[Abstract] [Full Text] [PDF]
K. Kuhlbrodt, C. Schmidt, E. Sock, V. Pingault, N. Bondurand, M. Goossens, and M. Wegner
Functional Analysis of Sox10 Mutations Found in Human Waardenburg-Hirschsprung Patients
J. Biol. Chem., September 4, 1998; 273(36): 23033 - 23038.
[Abstract] [Full Text] [PDF]
K. Kuhlbrodt, B. Herbarth, E. Sock, J. Enderich, I. Hermans-Borgmeyer, and M. Wegner
Cooperative Function of POU Proteins and SOX Proteins in Glial Cells
J. Biol. Chem., June 26, 1998; 273(26): 16050 - 16057.
[Abstract] [Full Text] [PDF]
B. Herbarth, V. Pingault, N. Bondurand, K. Kuhlbrodt, I. Hermans-Borgmeyer, A. Puliti, N. Lemort, M. Goossens, and M. Wegner
Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease
PNAS, April 28, 1998; 95(9): 5161 - 5165.
[Abstract] [Full Text] [PDF]
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