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The Journal of Neuroscience, January 1, 1998, 18(1):237-250
Sox10, a Novel Transcriptional Modulator in Glial Cells
Kirsten
Kuhlbrodt,
Beate
Herbarth,
Elisabeth
Sock,
Irm
Hermans-Borgmeyer, and
Michael
Wegner
Zentrum für Molekulare Neurobiologie, Universität
Hamburg, D-20246 Hamburg, Germany
Sox proteins are characterized by possession of a DNA-binding
domain with similarity to the high-mobility group domain of the sex
determining factor SRY. Here, we report on Sox10, a novel protein with
predominant expression in glial cells of the nervous system. During
development Sox10 first appeared in the forming neural crest and
continued to be expressed as these cells contributed to the forming PNS
and finally differentiated into Schwann cells. In the CNS, Sox10
transcripts were originally confined to glial precursors and later
detected in oligodendrocytes of the adult brain. Functional studies
failed to reveal autonomous transcriptional activity for Sox10.
Instead, Sox10 functioned synergistically with the POU domain protein
Tst-1/Oct6/SCIP with which it is coexpressed during certain stages of
Schwann cell development. Synergy depended on binding to adjacent sites
in target promoters, was mediated by the N-terminal regions of both
proteins, and could not be observed between Sox10 and several other POU
domain proteins. Interestingly, Sox10 also modulated the function of
Pax3 and Krox-20, two other transcription factors involved in Schwann
cell development. We propose a role for Sox10 in conferring cell
specificity to the function of other transcription factors in
developing and mature glia.
Key words:
POU; Sox; synergy; neural crest; Schwann cell; oligodendrocyte
Copyright © 1998 Society for Neuroscience 0270-6474/98/181237-14$05.00/0
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130(17):
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[Abstract]
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[Abstract]
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