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Previous Article | Next Article
The Journal of Neuroscience, January 1, 1998, 18(1):251-265
Sorting of
-Actin mRNA and Protein to Neurites and Growth Cones in Culture
Gary J. Bassell1, Honglai Zhang1, Anne L. Byrd1, Andrea M. Femino1, Robert H. Singer1, Krishan L. Taneja2, Lawrence M. Lifshitz3, Ira M. Herman4, and Kenneth S. Kosik5 1 Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, 2 Department of Cell Biology and 3 Biomedical Imaging Group, University of Massachusetts Medical Center, Worcester, Massachusetts 10615, 4 Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts, and 5 Center for Neurological Disease, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
The transport of mRNAs into developing dendrites and axons may be a basic mechanism to localize cytoskeletal proteins to growth cones and influence microfilament organization. Using isoform-specific antibodies and probes for in situ hybridization, we observed distinct localization patterns for
- and
-actin within cultured cerebrocortical neurons.
Key words: mRNA localization; actin isoforms; cytoskeleton; growth cones; axonal transport; in situ hybridization
Copyright © 1998 Society for Neuroscience 0270-6474/98/181251-15$05.00/0
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