 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, January 1, 1998, 18(1):388-398
Gamma Oscillations in the Entorhinal Cortex of the Freely Behaving Rat
J. J. Chrobak and G. Buzsáki Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102
Gamma frequency field oscillations (40-100 Hz) are nested within theta oscillations in the dentate-hilar and CA1-CA3 regions of the hippocampus during exploratory behaviors. These oscillations reflect synchronized synaptic potentials that entrain the discharge of neuronal populations within the ~10-25 msec range. Using multisite recordings in freely behaving rats, we examined gamma oscillations within the superficial layers (I-III) of the entorhinal cortex. These oscillations increased in amplitude and regularity in association with entorhinal theta waves. Gamma waves showed an amplitude minimum and reversed in phase near the perisomatic region of layer II, indicating that they represent synchronized synaptic potentials impinging on layer II-III neurons. Theta and gamma oscillations in the entorhinal cortex were coupled with theta and gamma oscillations in the dentate hilar region. The majority of layer II-III neurons discharged irregularly but were phase-related to the negative peak of the local (layer II-III) gamma field oscillation. These findings demonstrate that layer II-III neurons discharge in temporally defined gamma windows (~10-25 msec) coupled to the theta cycle. This transient temporal framework, which emerges in both the entorhinal cortex and the hippocampus, may allow spatially distributed subpopulations to form temporally defined ensembles. We speculate that the theta-gamma pattern in the discharge of these neurons is essential for effective neuronal communication and synaptic plasticity in the perforant pathway.
Key words: neuronal cooperativity; unit activity; theta waves; gamma; plasticity; Alzheimer's dementia; perforant pathway; LTP/LTD
Copyright © 1998 Society for Neuroscience 0270-6474/98/181388-11$05.00/0
This article has been cited by other articles:
T. Tsujimoto, H. Shimazu, Y. Isomura, and K. Sasaki
Theta Oscillations in Primate Prefrontal and Anterior Cingulate Cortices in Forewarned Reaction Time Tasks
J Neurophysiol, February 1, 2010; 103(2): 827 - 843.
[Abstract] [Full Text] [PDF]
M. Siegel, M. R. Warden, and E. K. Miller
From the Cover: Phase-dependent neuronal coding of objects in short-term memory
PNAS, December 15, 2009; 106(50): 21341 - 21346.
[Abstract] [Full Text] [PDF]
K. I. van Aerde, E. O. Mann, C. B. Canto, T. S. Heistek, K. Linkenkaer-Hansen, A. B. Mulder, M. van der Roest, O. Paulsen, A. B. Brussaard, and H. D. Mansvelder
Flexible spike timing of layer 5 neurons during dynamic beta oscillation shifts in rat prefrontal cortex
J. Physiol., November 1, 2009; 587(21): 5177 - 5196.
[Abstract] [Full Text] [PDF]
J. Jacobs and M. J. Kahana
Neural Representations of Individual Stimuli in Humans Revealed by Gamma-Band Electrocorticographic Activity
J. Neurosci., August 19, 2009; 29(33): 10203 - 10214.
[Abstract] [Full Text] [PDF]
K. Dzirasa, A. J. Ramsey, D. Y. Takahashi, J. Stapleton, J. M. Potes, J. K. Williams, R. R. Gainetdinov, K. Sameshima, M. G. Caron, and M. A. L. Nicolelis
Hyperdopaminergia and NMDA Receptor Hypofunction Disrupt Neural Phase Signaling
J. Neurosci., June 24, 2009; 29(25): 8215 - 8224.
[Abstract] [Full Text] [PDF]
M. X Cohen, N. Axmacher, D. Lenartz, C. E. Elger, V. Sturm, and T. E. Schlaepfer
Nuclei Accumbens Phase Synchrony Predicts Decision-Making Reversals Following Negative Feedback
J. Neurosci., June 10, 2009; 29(23): 7591 - 7598.
[Abstract] [Full Text] [PDF]
H. R. Sabolek, S. C. Penley, J. R. Hinman, J. G. Bunce, E. J. Markus, M. Escabi, and J. J. Chrobak
Theta and Gamma Coherence Along the Septotemporal Axis of the Hippocampus
J Neurophysiol, March 1, 2009; 101(3): 1192 - 1200.
[Abstract] [Full Text] [PDF]
S. Middleton, J. Jalics, T. Kispersky, F. E. N. LeBeau, A. K. Roopun, N. J. Kopell, M. A. Whittington, and M. O. Cunningham
NMDA receptor-dependent switching between different gamma rhythm-generating microcircuits in entorhinal cortex
PNAS, November 25, 2008; 105(47): 18572 - 18577.
[Abstract] [Full Text] [PDF]
J. Lisman and G. Buzsaki
A Neural Coding Scheme Formed by the Combined Function of Gamma and Theta Oscillations
Schizophr Bull, September 1, 2008; 34(5): 974 - 980.
[Abstract] [Full Text] [PDF]
E. Calixto, E. J. Galvan, J. P. Card, and G. Barrionuevo
Coincidence detection of convergent perforant path and mossy fibre inputs by CA3 interneurons
J. Physiol., June 1, 2008; 586(11): 2695 - 2712.
[Abstract] [Full Text] [PDF]
E. D. Gireesh and D. Plenz
Neuronal avalanches organize as nested theta- and beta/gamma-oscillations during development of cortical layer 2/3
PNAS, May 27, 2008; 105(21): 7576 - 7581.
[Abstract] [Full Text] [PDF]
T. J. Senior, J. R. Huxter, K. Allen, J. O'Neill, and J. Csicsvari
Gamma Oscillatory Firing Reveals Distinct Populations of Pyramidal Cells in the CA1 Region of the Hippocampus
J. Neurosci., February 27, 2008; 28(9): 2274 - 2286.
[Abstract] [Full Text] [PDF]
R. Silver, K. Boahen, S. Grillner, N. Kopell, and K. L. Olsen
Neurotech for Neuroscience: Unifying Concepts, Organizing Principles, and Emerging Tools
J. Neurosci., October 31, 2007; 27(44): 11807 - 11819.
[Abstract] [Full Text] [PDF]
R. A. Koene and M. E. Hasselmo
First-In-First-Out Item Replacement in a Model of Short-Term Memory Based on Persistent Spiking
Cereb Cortex, August 1, 2007; 17(8): 1766 - 1781.
[Abstract] [Full Text] [PDF]
R. A. Bender, T. Kirschstein, O. Kretz, A. L. Brewster, C. Richichi, C. Ruschenschmidt, R. Shigemoto, H. Beck, M. Frotscher, and T. Z. Baram
Localization of HCN1 Channels to Presynaptic Compartments: Novel Plasticity That May Contribute to Hippocampal Maturation
J. Neurosci., April 25, 2007; 27(17): 4697 - 4706.
[Abstract] [Full Text] [PDF]
J. Jacobs, M. J. Kahana, A. D. Ekstrom, and I. Fried
Brain Oscillations Control Timing of Single-Neuron Activity in Humans
J. Neurosci., April 4, 2007; 27(14): 3839 - 3844.
[Abstract] [Full Text] [PDF]
T. Radman, Y. Su, J. H. An, L. C. Parra, and M. Bikson
Spike Timing Amplifies the Effect of Electric Fields on Neurons: Implications for Endogenous Field Effects
J. Neurosci., March 14, 2007; 27(11): 3030 - 3036.
[Abstract] [Full Text] [PDF]
S.-C. Lin, D. Gervasoni, and M. A. L. Nicolelis
Fast Modulation of Prefrontal Cortex Activity by Basal Forebrain Noncholinergic Neuronal Ensembles
J Neurophysiol, December 1, 2006; 96(6): 3209 - 3219.
[Abstract] [Full Text] [PDF]
C. W. Ang, G. C. Carlson, and D. A. Coulter
Massive and Specific Dysregulation of Direct Cortical Input to the Hippocampus in Temporal Lobe Epilepsy.
J. Neurosci., November 15, 2006; 26(46): 11850 - 11856.
[Abstract] [Full Text] [PDF]
I. van Welie, M. W. H. Remme, J. A. van Hooft, and W. J. Wadman
Different levels of Ih determine distinct temporal integration in bursting and regular-spiking neurons in rat subiculum
J. Physiol., October 1, 2006; 576(1): 203 - 214.
[Abstract] [Full Text] [PDF]
R. T. Canolty, E. Edwards, S. S. Dalal, M. Soltani, S. S. Nagarajan, H. E. Kirsch, M. S. Berger, N. M. Barbaro, and R. T. Knight
High gamma power is phase-locked to theta oscillations in human neocortex.
Science, September 15, 2006; 313(5793): 1626 - 1628.
[Abstract] [Full Text] [PDF]
E. Labyt, L. Uva, M. de Curtis, and F. Wendling
Realistic Modeling of Entorhinal Cortex Field Potentials and Interpretation of Epileptic Activity in the Guinea Pig Isolated Brain Preparation
J Neurophysiol, July 1, 2006; 96(1): 363 - 377.
[Abstract] [Full Text] [PDF]
M. O. Cunningham, J. Hunt, S. Middleton, F. E. N. LeBeau, M. G. Gillies, C. H. Davies, P. R. Maycox, M. A. Whittington, and C. Racca
Region-specific reduction in entorhinal gamma oscillations and parvalbumin-immunoreactive neurons in animal models of psychiatric illness.
J. Neurosci., March 8, 2006; 26(10): 2767 - 2776.
[Abstract] [Full Text] [PDF]
C. W. Ang, G. C. Carlson, and D. A. Coulter
Hippocampal CA1 Circuitry Dynamically Gates Direct Cortical Inputs Preferentially at Theta Frequencies
J. Neurosci., October 19, 2005; 25(42): 9567 - 9580.
[Abstract] [Full Text] [PDF]
P. Lakatos, A. S. Shah, K. H. Knuth, I. Ulbert, G. Karmos, and C. E. Schroeder
An Oscillatory Hierarchy Controlling Neuronal Excitability and Stimulus Processing in the Auditory Cortex
J Neurophysiol, September 1, 2005; 94(3): 1904 - 1911.
[Abstract] [Full Text] [PDF]
C. Borgers, S. Epstein, and N. J. Kopell
Background gamma rhythmicity and attention in cortical local circuits: A computational study
PNAS, May 10, 2005; 102(19): 7002 - 7007.
[Abstract] [Full Text] [PDF]
J. M. Palva, S. Palva, and K. Kaila
Phase Synchrony among Neuronal Oscillations in the Human Cortex
J. Neurosci., April 13, 2005; 25(15): 3962 - 3972.
[Abstract] [Full Text] [PDF]
T. I. Netoff, M. I. Banks, A. D. Dorval, C. D. Acker, J. S. Haas, N. Kopell, and J. A. White
Synchronization in Hybrid Neuronal Networks of the Hippocampal Formation
J Neurophysiol, March 1, 2005; 93(3): 1197 - 1208.
[Abstract] [Full Text] [PDF]
R. D. Traub, A. Bibbig, F. E. N. LeBeau, M. O. Cunningham, and M. A. Whittington
Persistent gamma oscillations in superficial layers of rat auditory neocortex: experiment and model
J. Physiol., January 1, 2005; 562(1): 3 - 8.
[Abstract] [Full Text] [PDF]
N. Hajos, J. Palhalmi, E. O. Mann, B. Nemeth, O. Paulsen, and T. F. Freund
Spike Timing of Distinct Types of GABAergic Interneuron during Hippocampal Gamma Oscillations In Vitro
J. Neurosci., October 13, 2004; 24(41): 9127 - 9137.
[Abstract] [Full Text] [PDF]
I Erchova, G Kreck, U Heinemann, and A. V. M Herz
Dynamics of rat entorhinal cortex layer II and III cells: characteristics of membrane potential resonance at rest predict oscillation properties near threshold
J. Physiol., October 1, 2004; 560(1): 89 - 110.
[Abstract] [Full Text] [PDF]
S. J. Judge and M. E. Hasselmo
Theta Rhythmic Stimulation of Stratum Lacunosum-Moleculare in Rat Hippocampus Contributes to Associative LTP at a Phase Offset in Stratum Radiatum
J Neurophysiol, September 1, 2004; 92(3): 1615 - 1624.
[Abstract] [Full Text] [PDF]
D. A. Caruana and C. A. Chapman
Stimulation of the Parasubiculum Modulates Entorhinal Cortex Responses to Piriform Cortex Inputs In Vivo
J Neurophysiol, August 1, 2004; 92(2): 1226 - 1235.
[Abstract] [Full Text] [PDF]
S. Schreiber, I. Erchova, U. Heinemann, and A. V. M. Herz
Subthreshold Resonance Explains the Frequency-Dependent Integration of Periodic as Well as Random Stimuli in the Entorhinal Cortex
J Neurophysiol, July 1, 2004; 92(1): 408 - 415.
[Abstract] [Full Text] [PDF]
M. O. Cunningham, C. H. Davies, E. H. Buhl, N. Kopell, and M. A. Whittington
Gamma Oscillations Induced by Kainate Receptor Activation in the Entorhinal Cortex In Vitro
J. Neurosci., October 29, 2003; 23(30): 9761 - 9769.
[Abstract] [Full Text] [PDF]
C. T. Dickson, G. Biella, and M. de Curtis
Slow Periodic Events and Their Transition to Gamma Oscillations in the Entorhinal Cortex of the Isolated Guinea Pig Brain
J Neurophysiol, July 1, 2003; 90(1): 39 - 46.
[Abstract] [Full Text] [PDF]
M. Siegel and P. Konig
A Functional Gamma-Band Defined by Stimulus-Dependent Synchronization in Area 18 of Awake Behaving Cats
J. Neurosci., May 15, 2003; 23(10): 4251 - 4260.
[Abstract] [Full Text] [PDF]
J. E. Mikkonen, T. Gronfors, J. J. Chrobak, and M. Penttonen
Hippocampus Retains the Periodicity of Gamma Stimulation In Vivo
J Neurophysiol, November 1, 2002; 88(5): 2349 - 2354.
[Abstract] [Full Text] [PDF]
P. M. Baker, P. S. Pennefather, B. A. Orser, and F. K. Skinner
Disruption of Coherent Oscillations in Inhibitory Networks With Anesthetics: Role of GABAA Receptor Desensitization
J Neurophysiol, November 1, 2002; 88(5): 2821 - 2833.
[Abstract] [Full Text] [PDF]
H. Oya, H. Kawasaki, M. A. Howard III, and R. Adolphs
Electrophysiological Responses in the Human Amygdala Discriminate Emotion Categories of Complex Visual Stimuli
J. Neurosci., November 1, 2002; 22(21): 9502 - 9512.
[Abstract] [Full Text] [PDF]
L. M. Frank, U. T. Eden, V. Solo, M. A. Wilson, and E. N. Brown
Contrasting Patterns of Receptive Field Plasticity in the Hippocampus and the Entorhinal Cortex: An Adaptive Filtering Approach
J. Neurosci., May 1, 2002; 22(9): 3817 - 3830.
[Abstract] [Full Text] [PDF]
L. M. Frank, E. N. Brown, and M. A. Wilson
A Comparison of the Firing Properties of Putative Excitatory and Inhibitory Neurons From CA1 and the Entorhinal Cortex
J Neurophysiol, October 1, 2001; 86(4): 2029 - 2040.
[Abstract] [Full Text] [PDF]
K. Shimono, F. Brucher, R. Granger, G. Lynch, and M. Taketani
Origins and Distribution of Cholinergically Induced beta Rhythms in Hippocampal Slices
J. Neurosci., November 15, 2000; 20(22): 8462 - 8473.
[Abstract] [Full Text] [PDF]
C. T. Dickson, G. Biella, and M. de Curtis
Evidence for Spatial Modules Mediated by Temporal Synchronization of Carbachol-Induced Gamma Rhythm in Medial Entorhinal Cortex
J. Neurosci., October 15, 2000; 20(20): 7846 - 7854.
[Abstract] [Full Text] [PDF]
D. Ji and J. A. Dani
Inhibition and Disinhibition of Pyramidal Neurons by Activation of Nicotinic Receptors on Hippocampal Interneurons
J Neurophysiol, May 1, 2000; 83(5): 2682 - 2690.
[Abstract] [Full Text] [PDF]
J. V. Patterson, Y. Jin, M. Gierczak, W. P. Hetrick, S. Potkin, W. E. Bunney Jr, and C. A. Sandman
Effects of Temporal Variability on P50 and the Gating Ratio in Schizophrenia: A Frequency Domain Adaptive Filter Single-Trial Analysis
Arch Gen Psychiatry, January 1, 2000; 57(1): 57 - 64.
[Abstract] [Full Text] [PDF]
H. Dvorak-Carbone and E. M. Schuman
Patterned Activity in Stratum Lacunosum Moleculare Inhibits CA1 Pyramidal Neuron Firing
J Neurophysiol, December 1, 1999; 82(6): 3213 - 3222.
[Abstract] [Full Text] [PDF]
S. van der Linden, F. Panzica, and M. de Curtis
Carbachol Induces Fast Oscillations in the Medial but not in the Lateral Entorhinal Cortex of the Isolated Guinea Pig Brain
J Neurophysiol, November 1, 1999; 82(5): 2441 - 2450.
[Abstract] [Full Text] [PDF]
J. S. Kwon, B. F. O'Donnell, G. V. Wallenstein, R. W. Greene, Y. Hirayasu, P. G. Nestor, M. E. Hasselmo, G. F. Potts, M. E. Shenton, and R. W. McCarley
Gamma Frequency-Range Abnormalities to Auditory Stimulation in Schizophrenia
Arch Gen Psychiatry, November 1, 1999; 56(11): 1001 - 1005.
[Abstract] [Full Text] [PDF]
E. Bracci, M. Vreugdenhil, S. P. Hack, and J. G. R. Jefferys
On the Synchronizing Mechanisms of Tetanically Induced Hippocampal Oscillations
J. Neurosci., September 15, 1999; 19(18): 8104 - 8113.
[Abstract] [Full Text] [PDF]
D. N. Ruskin, D. A. Bergstrom, and J. R. Walters
Multisecond Oscillations in Firing Rate in the Globus Pallidus: Synergistic Modulation by D1 and D2 Dopamine Receptors
J. Pharmacol. Exp. Ther., September 1, 1999; 290(3): 1493 - 1501.
[Abstract] [Full Text]
B. Kocsis, A. Bragin, and G. Buzsaki
Interdependence of Multiple Theta Generators in the Hippocampus: a Partial Coherence Analysis
J. Neurosci., July 15, 1999; 19(14): 6200 - 6212.
[Abstract] [Full Text] [PDF]
D. N. Ruskin, D. A. Bergstrom, Y. Kaneoke, B. N. Patel, M. J. Twery, and J. R. Walters
Multisecond Oscillations in Firing Rate in the Basal Ganglia: Robust Modulation by Dopamine Receptor Activation and Anesthesia
J Neurophysiol, May 1, 1999; 81(5): 2046 - 2055.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|