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The Journal of Neuroscience, January 1, 1998, 18(1):512-520
Postnatal Development of Phase-Locked High-Fidelity Synaptic
Transmission in the Medial Nucleus of the Trapezoid Body of the
Rat
Nao
Chuhma and
Harunori
Ohmori
Department of Physiology, Faculty of Medicine, Kyoto University,
Kyoto 606-01, Japan
Synaptic transmission in the medial nucleus of the trapezoid body
of rats was analyzed in postnatal days 4-13 (P4-P13) by applying the
whole-cell patch-recording technique to brain slices. In P4-P6
animals, evoked EPSCs fluctuated extensively in amplitude and occurred
in marked asynchrony, followed by spontaneous EPSCs. With development
of animals, the evoked EPSCs increased in amplitude, and the rise time
became faster. In addition, the synaptic transmission became
phase-locked. The coefficient of variation (CV) of EPSC amplitude
decreased with development (0.32 ± 0.03 for P4-P5 and 0.05 ± 0.01 for P9-P11). The amplitude of miniature EPSCs did not change
throughout the postnatal days investigated ( 30.2 ± 0.3 pA at
70 mV). The CV was dependent on extracellular
Ca2+ concentration
([Ca2+]o) and was reduced with
the increase of [Ca2+]o, and
this [Ca2+]o dependence was shifted
toward lower [Ca2+]o with development.
Direct patch recording of the presynaptic terminals demonstrated an
increase in Ca2+ currents during these postnatal
days. The phase-locked high-fidelity transmission in this synapse is
achieved with development likely through the increase of
Ca2+ currents and Ca2+
sensitivity of transmitter release mechanisms in the presynaptic terminal.
Key words:
MNTB; development; synapse; EPSC; coefficient of
variation; presynaptic Ca2+ currents; calyx of
Held
Copyright © 1998 Society for Neuroscience 0270-6474/98/181512-09$05.00/0
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