QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (55) Citing Articles via Google Scholar Google Scholar Articles by Chuhma, N. Articles by Ohmori, H. Search for Related Content PubMed PubMed Citation Articles by Chuhma, N. Articles by Ohmori, H.

 Previous Article  |  Next Article 

The Journal of Neuroscience, January 1, 1998, 18(1):512-520

Postnatal Development of Phase-Locked High-Fidelity Synaptic Transmission in the Medial Nucleus of the Trapezoid Body of the Rat

Nao Chuhma and Harunori Ohmori

Department of Physiology, Faculty of Medicine, Kyoto University, Kyoto 606-01, Japan

Synaptic transmission in the medial nucleus of the trapezoid body of rats was analyzed in postnatal days 4-13 (P4-P13) by applying the whole-cell patch-recording technique to brain slices. In P4-P6 animals, evoked EPSCs fluctuated extensively in amplitude and occurred in marked asynchrony, followed by spontaneous EPSCs. With development of animals, the evoked EPSCs increased in amplitude, and the rise time became faster. In addition, the synaptic transmission became phase-locked. The coefficient of variation (CV) of EPSC amplitude decreased with development (0.32 ± 0.03 for P4-P5 and 0.05 ± 0.01 for P9-P11). The amplitude of miniature EPSCs did not change throughout the postnatal days investigated (30.2 ± 0.3 pA at 70 mV). The CV was dependent on extracellular Ca²⁺ concentration ([Ca²⁺]_o) and was reduced with the increase of [Ca²⁺]_o, and this [Ca²⁺]_o dependence was shifted toward lower [Ca²⁺]_o with development. Direct patch recording of the presynaptic terminals demonstrated an increase in Ca²⁺ currents during these postnatal days. The phase-locked high-fidelity transmission in this synapse is achieved with development likely through the increase of Ca²⁺ currents and Ca²⁺ sensitivity of transmitter release mechanisms in the presynaptic terminal.

Key words: MNTB; development; synapse; EPSC; coefficient of variation; presynaptic Ca²⁺ currents; calyx of Held

---

Copyright © 1998 Society for Neuroscience  0270-6474/98/181512-09$05.00/0

This article has been cited by other articles:

				R. A. Ingram, M. Fitzgerald, and M. L. Baccei Developmental Changes in the Fidelity and Short-Term Plasticity of GABAergic Synapses in the Neonatal Rat Dorsal Horn J Neurophysiol, June 1, 2008; 99(6): 3144 - 3150. [Abstract] [Full Text] [PDF]

				A. Rodriguez-Contreras, J. S. S. van Hoeve, R. L. P. Habets, H. Locher, and J. G. G. Borst Dynamic development of the calyx of Held synapse PNAS, April 8, 2008; 105(14): 5603 - 5608. [Abstract] [Full Text] [PDF]

				F. V. Chirila, K. C. Rowland, J. M. Thompson, and G. A. Spirou Development of gerbil medial superior olive: integration of temporally delayed excitation and inhibition at physiological temperature J. Physiol., October 1, 2007; 584(1): 167 - 190. [Abstract] [Full Text] [PDF]

				M. Youssoufian, S. Oleskevich, and B. Walmsley Development of a Robust Central Auditory Synapse in Congenital Deafness J Neurophysiol, November 1, 2005; 94(5): 3168 - 3180. [Abstract] [Full Text] [PDF]

				A. K Magnusson, C. Kapfer, B. Grothe, and U. Koch Maturation of glycinergic inhibition in the gerbil medial superior olive after hearing onset J. Physiol., October 15, 2005; 568(2): 497 - 512. [Abstract] [Full Text] [PDF]

				H. Taschenberger, V. Scheuss, and E. Neher Release kinetics, quantal parameters and their modulation during short-term depression at a developing synapse in the rat CNS J. Physiol., October 15, 2005; 568(2): 513 - 537. [Abstract] [Full Text] [PDF]

				R. Renden, H. Taschenberger, N. Puente, D. A. Rusakov, R. Duvoisin, L.-Y. Wang, K. P. Lehre, and H. von Gersdorff Glutamate Transporter Studies Reveal the Pruning of Metabotropic Glutamate Receptors and Absence of AMPA Receptor Desensitization at Mature Calyx of Held Synapses J. Neurosci., September 14, 2005; 25(37): 8482 - 8497. [Abstract] [Full Text] [PDF]

				N. Korogod, X. Lou, and R. Schneggenburger Presynaptic Ca2+ Requirements and Developmental Regulation of Posttetanic Potentiation at the Calyx of Held J. Neurosci., May 25, 2005; 25(21): 5127 - 5137. [Abstract] [Full Text] [PDF]

				S Oleskevich, M Youssoufian, and B Walmsley Presynaptic plasticity at two giant auditory synapses in normal and deaf mice J. Physiol., November 1, 2004; 560(3): 709 - 719. [Abstract] [Full Text] [PDF]

				I. Joshi, S. Shokralla, P. Titis, and L.-Y. Wang The Role of AMPA Receptor Gating in the Development of High-Fidelity Neurotransmission at the Calyx of Held Synapse J. Neurosci., January 7, 2004; 24(1): 183 - 196. [Abstract] [Full Text] [PDF]

				H. Kuba, R. Yamada, and H. Ohmori Evaluation of the limiting acuity of coincidence detection in nucleus laminaris of the chicken J. Physiol., October 15, 2003; 552(2): 611 - 620. [Abstract] [Full Text] [PDF]

				T. Yamashita, T. Ishikawa, and T. Takahashi Developmental Increase in Vesicular Glutamate Content Does Not Cause Saturation of AMPA Receptors at the Calyx of Held Synapse J. Neurosci., May 1, 2003; 23(9): 3633 - 3638. [Abstract] [Full Text] [PDF]

				R. M. Leao and H. Von Gersdorff Noradrenaline Increases High-Frequency Firing at the Calyx of Held Synapse During Development by Inhibiting Glutamate Release J Neurophysiol, May 1, 2002; 87(5): 2297 - 2306. [Abstract] [Full Text] [PDF]

				I. Joshi and L.-Y. Wang Developmental profiles of glutamate receptors and synaptic transmission at a single synapse in the mouse auditory brainstem J. Physiol., May 1, 2002; 540(3): 861 - 873. [Abstract] [Full Text] [PDF]

				H. Kuba, K. Koyano, and H. Ohmori Development of membrane conductance improves coincidence detection in the nucleus laminaris of the chicken J. Physiol., April 15, 2002; 540(2): 529 - 542. [Abstract] [Full Text] [PDF]

				V. Scheuss, R. Schneggenburger, and E. Neher Separation of Presynaptic and Postsynaptic Contributions to Depression by Covariance Analysis of Successive EPSCs at the Calyx of Held Synapse J. Neurosci., February 1, 2002; 22(3): 728 - 739. [Abstract] [Full Text] [PDF]

				N. Chuhma and H. Ohmori Role of Ca2+ in the Synchronization of Transmitter Release at Calyceal Synapses in the Auditory System of Rat J Neurophysiol, January 1, 2002; 87(1): 222 - 228. [Abstract] [Full Text] [PDF]

				E. Neher and T. Sakaba Estimating Transmitter Release Rates from Postsynaptic Current Fluctuations J. Neurosci., December 15, 2001; 21(24): 9638 - 9654. [Abstract] [Full Text] [PDF]

				S. Brenowitz and L. O. Trussell Maturation of Synaptic Transmission at End-Bulb Synapses of the Cochlear Nucleus J. Neurosci., December 1, 2001; 21(23): 9487 - 9498. [Abstract] [Full Text] [PDF]

				A. C. Meyer, E. Neher, and R. Schneggenburger Estimation of Quantal Size and Number of Functional Active Zones at the Calyx of Held Synapse by Nonstationary EPSC Variance Analysis J. Neurosci., October 15, 2001; 21(20): 7889 - 7900. [Abstract] [Full Text] [PDF]

				Y. Sahara and T. Takahashi Quantal components of the excitatory postsynaptic currents at a rat central auditory synapse J. Physiol., October 1, 2001; 536(1): 189 - 197. [Abstract] [Full Text] [PDF]

				S. Iwasaki and T. Takahashi Developmental regulation of transmitter release at the calyx of Held in rat auditory brainstem J. Physiol., August 1, 2001; 534(3): 861 - 871. [Abstract] [Full Text] [PDF]

				N. Chuhma, K. Koyano, and H. Ohmori Synchronisation ofneurotransmitter release during postnatal development in a calyceal presynaptic terminal of rat J. Physiol., January 1, 2001; 530(1): 93 - 104. [Abstract] [Full Text] [PDF]

				H. Taschenberger and H. von Gersdorff Fine-Tuning an Auditory Synapse for Speed and Fidelity: Developmental Changes in Presynaptic Waveform, EPSC Kinetics, and Synaptic Plasticity J. Neurosci., December 15, 2000; 20(24): 9162 - 9173. [Abstract] [Full Text] [PDF]

				S. Iwasaki, A. Momiyama, O. D. Uchitel, and T. Takahashi Developmental Changes in Calcium Channel Types Mediating Central Synaptic Transmission J. Neurosci., January 1, 2000; 20(1): 59 - 65. [Abstract] [Full Text] [PDF]

				M. C Bellingham, R. Lim, and B. Walmsley Developmental changes in EPSC quantal size and quantal content at a central glutamatergic synapse in rat J. Physiol., September 15, 1998; 511(3): 861 - 869. [Abstract] [Full Text] [PDF]

				S. Iwasaki and T. Takahashi Developmental changes in calcium channel types mediating synaptic transmission in rat auditory brainstem J. Physiol., June 1, 1998; 509(2): 419 - 423. [Abstract] [Full Text] [PDF]

				H. Kuba, K. Koyano, and H. Ohmori Development of membrane conductance improves coincidence detection in the nucleus laminaris of the chicken J. Physiol., April 15, 2002; 540(2): 529 - 542. [Abstract] [Full Text] [PDF]

				I. Joshi and L.-Y. Wang Developmental profiles of glutamate receptors and synaptic transmission at a single synapse in the mouse auditory brainstem J. Physiol., May 1, 2002; 540(3): 861 - 873. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help