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The Journal of Neuroscience, May 15, 1998, 18(10):3501-3510
Determinants of Voltage Attenuation in Neocortical Pyramidal Neuron Dendrites
Greg Stuart1, 3 and Nelson Spruston2, 3 1 Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, A.C.T. 0200, Australia, 2 Department of Neurobiology and Physiology, Institute for Neuroscience, Northwestern University, Evanston, Illinois 60208-3520, and 3 Max Planck Institut für Medizinische Forschung, Abteilung Zellphysiologie, Heidelberg, 69120, Germany
How effectively synaptic and regenerative potentials propagate within neurons depends critically on the membrane properties and intracellular resistivity of the dendritic tree. These properties therefore are important determinants of neuronal function. Here we use simultaneous whole-cell patch-pipette recordings from the soma and apical dendrite of neocortical layer 5 pyramidal neurons to directly measure voltage attenuation in cortical neurons. When combined with morphologically realistic compartmental models of the same cells, the data suggest that the intracellular resistivity of neocortical pyramidal neurons is relatively low (~70 to 100
cm), but that voltage attenuation is substantial because of nonuniformly distributed resting conductances present at a higher density in the distal apical dendrites. These conductances, which were largely blocked by bath application of CsCl (5 mM), significantly increased steady-state voltage attenuation and decreased EPSP integral and peak in a manner that depended on the location of the synapse. Together these findings suggest that nonuniformly distributed Cs-sensitive and -insensitive resting conductances generate a "leaky" apical dendrite, which differentially influences the integration of spatially segregated synaptic inputs.
Key words: voltage attenuation; dendrite; intracellular resistivity; neocortical pyramidal neuron; hyperpolarization-activated conductance; Ih; sag; cesium
Copyright © 1998 Society for Neuroscience 0270-6474/98/18103501-10$05.00/0
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