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The Journal of Neuroscience, May 15, 1998, 18(10):3521-3528
Downregulation of Transient K+ Channels in Dendrites of Hippocampal CA1 Pyramidal Neurons by Activation of PKA and PKC
Dax A. Hoffman and Daniel Johnston Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
We have reported recently a high density of transient A-type K+ channels located in the distal dendrites of CA1 hippocampal pyramidal neurons and shown that these channels shape EPSPs, limit the back-propagation of action potentials, and prevent dendritic action potential initiation (). Because of the importance of these channels in dendritic signal propagation, their modulation by protein kinases would be of significant interest. We investigated the effects of activators of cAMP-dependent protein kinase (PKA) and the Ca2+-dependent phospholipid-sensitive protein kinase (PKC) on K+ channels in cell-attached patches from the distal dendrites of hippocampal CA1 pyramidal neurons. Inclusion of the membrane-permeant PKA activators 8-bromo-cAMP (8-br-cAMP) or forskolin in the dendritic patch pipette resulted in a depolarizing shift in the activation curve for the transient channels of ~15 mV. Activation of PKC by either of two phorbol esters also resulted in a 15 mV depolarizing shift of the activation curve. Neither PKA nor PKC activation affected the sustained or slowly inactivating component of the total outward current. This downregulation of transient K+ channels in the distal dendrites may be responsible for some of the frequently reported increases in cell excitability found after PKA and PKC activation. In support of this hypothesis, we found that activation of either PKA or PKC significantly increased the amplitude of back-propagating action potentials in distal dendrites.
Key words: potassium channels; IK(A); dendrite; protein kinase A; protein kinase C; hippocampus; phorbol esters; cAMP; action potential
Copyright © 1998 Society for Neuroscience 0270-6474/98/18103521-08$05.00/0
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A Role for the beta Isoform of Protein Kinase C in Fear Conditioning
J. Neurosci., August 15, 2000; 20(16): 5906 - 5914.
[Abstract] [Full Text] [PDF]
J. W. Y. Chen and R. A. Eatock
Major Potassium Conductance in Type I Hair Cells From Rat Semicircular Canals: Characterization and Modulation by Nitric Oxide
J Neurophysiol, July 1, 2000; 84(1): 139 - 151.
[Abstract] [Full Text] [PDF]
H. Tsubokawa, S. Offermanns, M. Simon, and M. Kano
Calcium-Dependent Persistent Facilitation of Spike Backpropagation in the CA1 Pyramidal Neurons
J. Neurosci., July 1, 2000; 20(13): 4878 - 4884.
[Abstract] [Full Text] [PDF]
R. Shibata, K. Nakahira, K. Shibasaki, Y. Wakazono, K. Imoto, and K. Ikenaka
A-Type K+ Current Mediated by the Kv4 Channel Regulates the Generation of Action Potential in Developing Cerebellar Granule Cells
J. Neurosci., June 1, 2000; 20(11): 4145 - 4155.
[Abstract] [Full Text] [PDF]
D. Johnston, D. A Hoffman, J. C Magee, N. P Poolos, S. Watanabe, C. M Colbert, and M. Migliore
Dendritic potassium channels in hippocampal pyramidal neurons
J. Physiol., May 15, 2000; 525(1): 75 - 81.
[Abstract] [Full Text] [PDF]
Z.-L. Guo and J. C. Longhurst
Role of cAMP in activation of ischemically sensitive abdominal visceral afferents
Am J Physiol Heart Circ Physiol, March 1, 2000; 278(3): H843 - H852.
[Abstract] [Full Text] [PDF]
A. E. Anderson, J. P. Adams, Y. Qian, R. G. Cook, P. J. Pfaffinger, and J. D. Sweatt
Kv4.2 Phosphorylation by Cyclic AMP-dependent Protein Kinase
J. Biol. Chem., February 25, 2000; 275(8): 5337 - 5346.
[Abstract] [Full Text] [PDF]
T. Tkatch, G. Baranauskas, and D. J. Surmeier
Kv4.2 mRNA Abundance and A-Type K+ Current Amplitude Are Linearly Related in Basal Ganglia and Basal Forebrain Neurons
J. Neurosci., January 15, 2000; 20(2): 579 - 588.
[Abstract] [Full Text] [PDF]
J. A. Rosenkranz and A. A. Grace
Modulation of Basolateral Amygdala Neuronal Firing and Afferent Drive by Dopamine Receptor Activation In Vivo
J. Neurosci., December 15, 1999; 19(24): 11027 - 11039.
[Abstract] [Full Text] [PDF]
A. S. Cohen, C. M. Coussens, C. R. Raymond, and W. C. Abraham
Long-Lasting Increase in Cellular Excitability Associated With the Priming of LTP Induction in Rat Hippocampus
J Neurophysiol, December 1, 1999; 82(6): 3139 - 3148.
[Abstract] [Full Text] [PDF]
J. Mu, S.-y. Zhuang, M. T. Kirby, R. E. Hampson, and S. A. Deadwyler
Cannabinoid Receptors Differentially Modulate Potassium A and D Currents in Hippocampal Neurons in Culture
J. Pharmacol. Exp. Ther., November 1, 1999; 291(2): 893 - 902.
[Abstract] [Full Text]
R. Xu, S.-G. Roh, K. Loneragan, M. Pullar, and C. Chen
Human GHRH reduces voltage-gated K+ currents via a non-cAMP-dependent but PKC-mediated pathway in human GH adenoma cells
J. Physiol., November 1, 1999; 520(3): 697 - 707.
[Abstract] [Full Text] [PDF]
J. C. Magee and M. Carruth
Dendritic Voltage-Gated Ion Channels Regulate the Action Potential Firing Mode of Hippocampal CA1 Pyramidal Neurons
J Neurophysiol, October 1, 1999; 82(4): 1895 - 1901.
[Abstract] [Full Text] [PDF]
C. M. Colbert and E. Pan
Arachidonic Acid Reciprocally Alters the Availability of Transient and Sustained Dendritic K+ Channels in Hippocampal CA1 Pyramidal Neurons
J. Neurosci., October 1, 1999; 19(19): 8163 - 8171.
[Abstract] [Full Text] [PDF]
V. Sourdet and D. Debanne
The Role of Dendritic Filtering in Associative Long-Term Synaptic Plasticity
Learn. Mem., September 1, 1999; 6(5): 422 - 447.
[Abstract] [Full Text]
T. Hori, Y. Takai, and T. Takahashi
Presynaptic Mechanism for Phorbol Ester-Induced Synaptic Potentiation
J. Neurosci., September 1, 1999; 19(17): 7262 - 7267.
[Abstract] [Full Text] [PDF]
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