 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, May 15, 1998, 18(10):3650-3658
A Novel Octopamine Receptor with Preferential Expression in Drosophila Mushroom Bodies
Kyung-An Han1, Neil S. Millar3, and Ronald L. Davis1, 2 Departments of 1 Cell Biology and 2 Neurology, Baylor College of Medicine, Houston, Texas 77030, and 3 Wellcome Laboratory for Molecular Pharmacology, Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
Octopamine is a neuromodulator that mediates diverse physiological processes in invertebrates. In some insects, such as honeybees and fruit flies, octopamine has been shown to be a major stimulator of adenylyl cyclase and to function in associative learning. To identify an octopamine receptor mediating this function in Drosophila, putative biogenic amine receptors were cloned by a novel procedure using PCR and single-strand conformation polymorphism. One new receptor, octopamine receptor in mushroom bodies (OAMB), was identified as an octopamine receptor because human and Drosophila cell lines expressing OAMB showed increased cAMP and intracellular Ca2+ levels after octopamine application. Immunohistochemical analysis using an antibody made to the receptor revealed highly enriched expression in the mushroom body neuropil and the ellipsoid body of central complex, brain areas known to be crucial for olfactory learning and motor control, respectively. The preferential expression of OAMB in mushroom bodies and its capacity to produce cAMP accumulation suggest an important role in synaptic modulation underlying behavioral plasticity.
Key words: adenylyl cyclase; single-strand conformation polymorphism; G-protein-coupled receptor; associative learning; octopamine receptor; mushroom bodies; neuromodulation
Copyright © 1998 Society for Neuroscience 0270-6474/98/18103650-09$05.00/0
This article has been cited by other articles:
G. C. Turner, M. Bazhenov, and G. Laurent
Olfactory Representations by Drosophila Mushroom Body Neurons
J Neurophysiol, February 1, 2008; 99(2): 734 - 746.
[Abstract] [Full Text] [PDF]
T. Farooqui
Octopamine-Mediated Neuronal Plasticity in Honeybees: Implications for Olfactory Dysfunction in Humans
Neuroscientist, August 1, 2007; 13(4): 304 - 322.
[Abstract] [PDF]
Y.-C. Kim, H.-G. Lee, and K.-A. Han
D1 Dopamine Receptor dDA1 Is Required in the Mushroom Body Neurons for Aversive and Appetitive Learning in Drosophila
J. Neurosci., July 18, 2007; 27(29): 7640 - 7647.
[Abstract] [Full Text] [PDF]
S. Suo, Y. Kimura, and H. H. M. Van Tol
Starvation Induces cAMP Response Element-Binding Protein-Dependent Gene Expression through Octopamine-Gq Signaling in Caenorhabditis elegans
J. Neurosci., October 4, 2006; 26(40): 10082 - 10090.
[Abstract] [Full Text] [PDF]
H. Gu and D. K. O'Dowd
Cholinergic Synaptic Transmission in Adult Drosophila Kenyon Cells In Situ
J. Neurosci., January 4, 2006; 26(1): 265 - 272.
[Abstract] [Full Text] [PDF]
G. M. Miller, C. D. Verrico, A. Jassen, M. Konar, H. Yang, H. Panas, M. Bahn, R. Johnson, and B. K. Madras
Primate Trace Amine Receptor 1 Modulation by the Dopamine Transporter
J. Pharmacol. Exp. Ther., June 1, 2005; 313(3): 983 - 994.
[Abstract] [Full Text] [PDF]
C. Lefebvre, J.-C. Aude, E. Glemet, and C. Neri
Balancing protein similarity and gene co-expression reveals new links between genetic conservation and developmental diversity in invertebrates
Bioinformatics, April 15, 2005; 21(8): 1550 - 1558.
[Abstract] [Full Text] [PDF]
A. Widmer, U. Hoger, S. Meisner, A. S. French, and P. H. Torkkeli
Spider Peripheral Mechanosensory Neurons Are Directly Innervated and Modulated by Octopaminergic Efferents
J. Neurosci., February 9, 2005; 25(6): 1588 - 1598.
[Abstract] [Full Text] [PDF]
M. C. Clark, T. E. Dever, J. J. Dever, P. Xu, V. Rehder, M. A. Sosa, and D. J. Baro
Arthropod 5-HT2 Receptors: A Neurohormonal Receptor in Decapod Crustaceans That Displays Agonist Independent Activity Resulting from an Evolutionary Alteration to the DRY Motif
J. Neurosci., March 31, 2004; 24(13): 3421 - 3435.
[Abstract] [Full Text] [PDF]
Z. Mao, G. Roman, L. Zong, and R. L. Davis
Pharmacogenetic rescue in time and space of the rutabaga memory impairment by using Gene-Switch
PNAS, January 6, 2004; 101(1): 198 - 203.
[Abstract] [Full Text] [PDF]
M. Schwaerzel, M. Monastirioti, H. Scholz, F. Friggi-Grelin, S. Birman, and M. Heisenberg
Dopamine and Octopamine Differentiate between Aversive and Appetitive Olfactory Memories in Drosophila
J. Neurosci., November 19, 2003; 23(33): 10495 - 10502.
[Abstract] [Full Text] [PDF]
H. Su and D. K. O'Dowd
Fast Synaptic Currents in Drosophila Mushroom Body Kenyon Cells Are Mediated by {alpha}-Bungarotoxin-Sensitive Nicotinic Acetylcholine Receptors and Picrotoxin-Sensitive GABA Receptors
J. Neurosci., October 8, 2003; 23(27): 9246 - 9253.
[Abstract] [Full Text] [PDF]
D. Hou, K. Suzuki, W. J. Wolfgang, C. Clay, M. Forte, and Y. Kidokoro
Presynaptic Impairment of Synaptic Transmission in Drosophila Embryos Lacking Gs{alpha}
J. Neurosci., July 2, 2003; 23(13): 5897 - 5905.
[Abstract] [Full Text] [PDF]
T. Farooqui, K. Robinson, H. Vaessin, and B. H. Smith
Modulation of Early Olfactory Processing by an Octopaminergic Reinforcement Pathway in the Honeybee
J. Neurosci., June 15, 2003; 23(12): 5370 - 5380.
[Abstract] [Full Text] [PDF]
D. Yu, G. S. Baird, R. Y. Tsien, and R. L. Davis
Detection of Calcium Transients in Drosophila Mushroom Body Neurons with Camgaroo Reporters
J. Neurosci., January 1, 2003; 23(1): 64 - 72.
[Abstract] [Full Text] [PDF]
M. G. Hearn, Y. Ren, E. W. McBride, I. Reveillaud, M. Beinborn, and A. S. Kopin
A Drosophila dopamine 2-like receptor: Molecular characterization and identification of multiple alternatively spliced variants
PNAS, October 29, 2002; 99(22): 14554 - 14559.
[Abstract] [Full Text] [PDF]
A. Baier, B. Wittek, and B. Brembs
Drosophila as a new model organism for the neurobiology of aggression?
J. Exp. Biol., May 1, 2002; 205(9): 1233 - 1240.
[Abstract] [Full Text] [PDF]
B. Wenzel, N. Elsner, and R. Heinrich
mAChRs in the Grasshopper Brain Mediate Excitation by Activation of the AC/PKA and the PLC Second-Messenger Pathways
J Neurophysiol, February 1, 2002; 87(2): 876 - 888.
[Abstract] [Full Text] [PDF]
B. Borowsky, N. Adham, K. A. Jones, R. Raddatz, R. Artymyshyn, K. L. Ogozalek, M. M. Durkin, P. P. Lakhlani, J. A. Bonini, S. Pathirana, et al.
Trace amines: Identification of a family of mammalian G protein-coupled receptors
PNAS, July 13, 2001; (2001) 151105198.
[Abstract] [Full Text] [PDF]
W. J. Wolfgang, A. Hoskote, I. J. H. Roberts, S. Jackson, and M. Forte
Genetic Analysis of the Drosophila Gs{{alpha}} Gene
Genetics, July 1, 2001; 158(3): 1189 - 1201.
[Abstract] [Full Text] [PDF]
T. Brody and A. Cravchik
Drosophila melanogaster G Protein-coupled Receptors
J. Cell Biol., July 24, 2000; 150(2): F83 - F88.
[Abstract] [Full Text] [PDF]
T. Zars, M. Fischer, R. Schulz, and M. Heisenberg
Localization of a Short-Term Memory in Drosophila
Science, April 28, 2000; 288(5466): 672 - 675.
[Abstract] [Full Text]
S. Oleskevich
Cholinergic Synaptic Transmission in Insect Mushroom Bodies In Vitro
J Neurophysiol, August 1, 1999; 82(2): 1091 - 1096.
[Abstract] [Full Text] [PDF]
B. Borowsky, N. Adham, K. A. Jones, R. Raddatz, R. Artymyshyn, K. L. Ogozalek, M. M. Durkin, P. P. Lakhlani, J. A. Bonini, S. Pathirana, et al.
From the Cover: Trace amines: Identification of a family of mammalian G protein-coupled receptors
PNAS, July 31, 2001; 98(16): 8966 - 8971.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|