WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience Join the Society for Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (492)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Namura, S.
Right arrow Articles by Moskowitz, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Namura, S.
Right arrow Articles by Moskowitz, M. A.

 Previous Article  |  Next Article 

The Journal of Neuroscience, May 15, 1998, 18(10):3659-3668

Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia

Shobu Namura1, Jinmin Zhu1, Klaus Fink1, Matthias Endres1, Anu Srinivasan2, Kevin J. Tomaselli2, Junying Yuan3, and Michael A. Moskowitz1

1 Stroke and Neurovascular Regulation, Neurosurgical Service, Departments of Surgery and Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, 2 IDUN Pharmaceuticals, Inc., La Jolla, California 92037, and 3 Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115

We examined the expression, activation, and cellular localization of caspase-3 (CPP32) using immunohistochemistry, immunoblots, and cleavage of the fluorogenic substrate N-benzyloxycarbonyl-Asp-Glu-Val-Asp-7-amino-4-trifluoromethyl coumarin (zDEVD-afc) in adult mouse brain after temporary (2 hr) middle cerebral artery occlusion produced by filament insertion into the carotid artery. Immunoreactive caspase-3p32 but not its cleavage product caspase-3p20 was constitutively expressed in neurons throughout brain and was most prominent in neuronal perikarya within piriform cortex. Caspase-like enzyme activity was elevated in brain homogenate 0-3 hr after reperfusion and reached a peak within 30 to 60 min. Caspase-3p20 immunoreactivity became prominent in neuronal perikarya within the middle cerebral artery territory at the time of reperfusion and on immunoblots 1-12 hr later. DNA laddering (agarose gels) and terminal deoxynucleotidyl transferase-mediated dUTP---biotin nick-end labeling (TUNEL)-stained cells were detected 6-24 hr after reperfusion. At 12-24 hr, immunoreactive p20 was visualized in TUNEL-positive cells, a finding also observed in apoptotic mouse cerebellar granule cells on postnatal day 5. Together, these observations suggest the existence of a time-dependent evolution of ischemic injury characterized by the close correspondence between caspase-like enzyme activation and an associated increase in immunoreactive product (caspase-3p20) beginning at or before reperfusion and followed several hours later by morphological and biochemical features of apoptosis.

Key words: ischemia; caspase; CED-3/ICE proteases; mouse brain; apoptosis; caspase-3 cleavage; caspase-like enzyme activity; TUNEL; CNS development

Copyright © 1998 Society for Neuroscience  0270-6474/98/18103659-10$05.00/0


This article has been cited by other articles:


Home page
 J EndocrinolHome page
H. Chung, S. Seo, M. Moon, and S. Park
Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3{beta} and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells
J. Endocrinol., September 1, 2008; 198(3): 511 - 521.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
E. C. Steele Jr, Q. Guo, and S. Namura
Filamentous Middle Cerebral Artery Occlusion Causes Ischemic Damage to the Retina in Mice
Stroke, July 1, 2008; 39(7): 2099 - 2104.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. A. Khan, X. O. Mao, S. Banwait, C. M. DerMardirossian, G. M. Bokoch, K. Jin, and D. A. Greenberg
Regulation of hypoxic neuronal death signaling by neuroglobin
FASEB J, June 1, 2008; 22(6): 1737 - 1747.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
T. C. Dinger, S. Eckardt, S. W. Choi, G. Camarero, S. Kurosaka, V. Hornich, K. J. McLaughlin, and A. M. Muller
Androgenetic Embryonic Stem Cells Form Neural Progenitor Cells In Vivo and In Vitro
Stem Cells, June 1, 2008; 26(6): 1474 - 1483.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
K. Adachi, Z. Mirzadeh, M. Sakaguchi, T. Yamashita, T. Nikolcheva, Y. Gotoh, G. Peltz, L. Gong, T. Kawase, A. Alvarez-Buylla, et al.
{beta}-Catenin Signaling Promotes Proliferation of Progenitor Cells in the Adult Mouse Subventricular Zone
Stem Cells, November 1, 2007; 25(11): 2827 - 2836.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Z. Xie, Y. Dong, U. Maeda, R. D. Moir, W. Xia, D. J. Culley, G. Crosby, and R. E. Tanzi
The Inhalation Anesthetic Isoflurane Induces a Vicious Cycle of Apoptosis and Amyloid {beta}-Protein Accumulation
J. Neurosci., February 7, 2007; 27(6): 1247 - 1254.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. B. Dubal, S. W. Rau, P. J. Shughrue, H. Zhu, J. Yu, A. B. Cashion, S. Suzuki, L. M. Gerhold, M. B. Bottner, S. B. Dubal, et al.
Differential Modulation of Estrogen Receptors (ERs) in Ischemic Brain Injury: A Role for ER{alpha} in Estradiol-Mediated Protection against Delayed Cell Death
Endocrinology, June 1, 2006; 147(6): 3076 - 3084.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
N. Mori, Y. Ishiba, S. Kubota, A. Kobayashi, T. Higashide, M. J. McLaren, and G. Inana
Truncation Mutation in HRG4 (UNC119) Leads to Mitochondrial ANT-1-Mediated Photoreceptor Synaptic and Retinal Degeneration by Apoptosis.
Invest. Ophthalmol. Vis. Sci., April 1, 2006; 47(4): 1281 - 1292.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Culmsee, C. Zhu, S. Landshamer, B. Becattini, E. Wagner, M. Pellecchia, K. Blomgren, and N. Plesnila
Apoptosis-Inducing Factor Triggered by Poly(ADP-Ribose) Polymerase and Bid Mediates Neuronal Cell Death after Oxygen-Glucose Deprivation and Focal Cerebral Ischemia
J. Neurosci., November 2, 2005; 25(44): 10262 - 10272.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
P. H. Chan
Future Targets and Cascades for Neuroprotective Strategies
Stroke, November 1, 2004; 35(11_suppl_1): 2748 - 2750.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Okuno, A. Saito, T. Hayashi, and P. H. Chan
The c-Jun N-Terminal Protein Kinase Signaling Pathway Mediates Bax Activation and Subsequent Neuronal Apoptosis through Interaction with Bim after Transient Focal Cerebral Ischemia
J. Neurosci., September 8, 2004; 24(36): 7879 - 7887.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
I. Unal-Cevik, M. Kilinc, A. Can, Y. Gursoy-Ozdemir, and T. Dalkara
Apoptotic and Necrotic Death Mechanisms Are Concomitantly Activated in the Same Cell After Cerebral Ischemia
Stroke, September 1, 2004; 35(9): 2189 - 2194.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
Y. Sui, R. Potula, N. Dhillon, D. Pinson, S. Li, A. Nath, C. Anderson, J. Turchan, D. Kolson, O. Narayan, et al.
Neuronal Apoptosis Is Mediated by CXCL10 Overexpression in Simian Human Immunodeficiency Virus Encephalitis
Am. J. Pathol., May 1, 2004; 164(5): 1557 - 1566.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. A. Hossain, J. C. Russell, R. O'Brien, and J. Laterra
Neuronal Pentraxin 1: A Novel Mediator of Hypoxic-Ischemic Injury in Neonatal Brain
J. Neurosci., April 28, 2004; 24(17): 4187 - 4196.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
J. Qiu, Y. Takagi, J. Harada, N. Rodrigues, M. A. Moskowitz, D. T. Scadden, and T. Cheng
Regenerative Response in Ischemic Brain Restricted by p21cip1/waf1
J. Exp. Med., April 5, 2004; 199(7): 937 - 945.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
M. Kawaguchi, J. C. Drummond, D. J. Cole, P. J. Kelly, M. P. Spurlock, and P. M. Patel
Effect of Isoflurane on Neuronal Apoptosis in Rats Subjected to Focal Cerebral Ischemia
Anesth. Analg., March 1, 2004; 98(3): 798 - 805.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Saito, P. Narasimhan, T. Hayashi, S. Okuno, M. Ferrand-Drake, and P. H. Chan
Neuroprotective Role of a Proline-Rich Akt Substrate in Apoptotic Neuronal Cell Death after Stroke: Relationships with Nerve Growth Factor
J. Neurosci., February 18, 2004; 24(7): 1584 - 1593.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. W. Rau, D. B. Dubal, M. Bottner, L. M. Gerhold, and P. M. Wise
Estradiol Attenuates Programmed Cell Death after Stroke-Like Injury
J. Neurosci., December 10, 2003; 23(36): 11420 - 11426.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. W. Rau, D. B. Dubal, M. Bottner, and P. M. Wise
Estradiol Differentially Regulates c-Fos after Focal Cerebral Ischemia
J. Neurosci., November 19, 2003; 23(33): 10487 - 10494.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Tesco, Y. H. Koh, and R. E. Tanzi
Caspase Activation Increases {beta}-Amyloid Generation Independently of Caspase Cleavage of the {beta}-Amyloid Precursor Protein (APP)
J. Biol. Chem., November 14, 2003; 278(46): 46074 - 46080.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. A. Guimaraes, M. Benchimol, G. P. Amarante-Mendes, and R. Linden
Alternative Programs of Cell Death in Developing Retinal Tissue
J. Biol. Chem., October 24, 2003; 278(43): 41938 - 41946.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
X. Cao, X. Deng, and W. S. May
Cleavage of Bax to p18 Bax accelerates stress-induced apoptosis, and a cathepsin-like protease may rapidly degrade p18 Bax
Blood, October 1, 2003; 102(7): 2605 - 2614.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
Y. Teshima, M. Akao, R. A. Li, T. H. Chong, W. A. Baumgartner, M. V. Johnston, and E. Marban
Mitochondrial ATP-Sensitive Potassium Channel Activation Protects Cerebellar Granule Neurons From Apoptosis Induced by Oxidative Stress
Stroke, July 1, 2003; 34(7): 1796 - 1802.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. Bizat, J.-M. Hermel, F. Boyer, C. Jacquard, C. Creminon, S. Ouary, C. Escartin, P. Hantraye, S. Kajewski, and E. Brouillet
Calpain Is a Major Cell Death Effector in Selective Striatal Degeneration Induced In Vivo by 3-Nitropropionate: Implications for Huntington's Disease
J. Neurosci., June 15, 2003; 23(12): 5020 - 5030.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
X. Wang, H. Wang, L. Xu, D. J. Rozanski, T. Sugawara, P. H. Chan, J. M. Trzaskos, and G. Z. Feuerstein
Significant Neuroprotection against Ischemic Brain Injury by Inhibition of the MEK1 Protein Kinase in Mice: Exploration of Potential Mechanism Associated with Apoptosis
J. Pharmacol. Exp. Ther., January 1, 2003; 304(1): 172 - 178.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
H. Mukai
The Structure and Function of PKN, a Protein Kinase Having a Catalytic Domain Homologous to That of PKC
J. Biochem., January 1, 2003; 133(1): 17 - 27.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. A. Le, Y. Wu, Z. Huang, K. Matsushita, N. Plesnila, J. C. Augustinack, B. T. Hyman, J. Yuan, K. Kuida, R. A. Flavell, et al.
Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation
PNAS, November 12, 2002; 99(23): 15188 - 15193.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Peng, Z. Wu, Y. Wu, M. Hsu, F. F. Stevenson, R. Boonplueang, S. K. Roffler-Tarlov, and J. K. Andersen
Inhibition of Caspases Protects Cerebellar Granule Cells of the Weaver Mouse from Apoptosis and Improves Behavioral Phenotype
J. Biol. Chem., November 8, 2002; 277(46): 44285 - 44291.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X.-M. Yin, Y. Luo, G. Cao, L. Bai, W. Pei, D. K. Kuharsky, and J. Chen
Bid-mediated Mitochondrial Pathway Is Critical to Ischemic Neuronal Apoptosis and Focal Cerebral Ischemia
J. Biol. Chem., October 25, 2002; 277(44): 42074 - 42081.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
S. L. Cotman, V. Vrbanac, L.-A. Lebel, R. L. Lee, K. A. Johnson, L.-R. Donahue, A. M. Teed, K. Antonellis, R. T. Bronson, T. J. Lerner, et al.
Cln3 {Delta}ex7/8 knock-in mice with the common JNCL mutation exhibit progressive neurologic disease that begins before birth
Hum. Mol. Genet., October 15, 2002; 11(22): 2709 - 2721.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
V. M. Borges, M. F. Lopes, H. Falcao, J. H. Leite-Junior, P. R. M. Rocco, W. F. Davidson, R. Linden, W. A. Zin, and G. A. DosReis
Apoptosis Underlies Immunopathogenic Mechanisms in Acute Silicosis
Am. J. Respir. Cell Mol. Biol., July 1, 2002; 27(1): 78 - 84.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Cao, W. Pei, H. Ge, Q. Liang, Y. Luo, F. R. Sharp, A. Lu, R. Ran, S. H. Graham, and J. Chen
In Vivo Delivery of a Bcl-xL Fusion Protein Containing the TAT Protein Transduction Domain Protects against Ischemic Brain Injury and Neuronal Apoptosis
J. Neurosci., July 1, 2002; 22(13): 5423 - 5431.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. A. Garden, S. L. Budd, E. Tsai, L. Hanson, M. Kaul, D. M. D'Emilia, R. M. Friedlander, J. Yuan, E. Masliah, and S. A. Lipton
Caspase Cascades in Human Immunodeficiency Virus-Associated Neurodegeneration
J. Neurosci., May 15, 2002; 22(10): 4015 - 4024.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. S. Silveira, M. R. Costa, M. Bozza, and R. Linden
Pituitary Adenylyl Cyclase-activating Polypeptide Prevents Induced Cell Death in Retinal Tissue through Activation of Cyclic AMP-dependent Protein Kinase
J. Biol. Chem., May 3, 2002; 277(18): 16075 - 16080.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. K. X. Maier, Z. Lahoua, N. H. Gendron, R. Fetni, A. Johnston, J. Davoodi, D. Rasper, S. Roy, R. S. Slack, D. W. Nicholson, et al.
The Neuronal Apoptosis Inhibitory Protein Is a Direct Inhibitor of Caspases 3 and 7
J. Neurosci., March 15, 2002; 22(6): 2035 - 2043.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Jover, H. Tanaka, A. Calderone, K. Oguro, M. V. L. Bennett, A. M. Etgen, and R. S. Zukin
Estrogen Protects against Global Ischemia-Induced Neuronal Death and Prevents Activation of Apoptotic Signaling Cascades in the Hippocampal CA1
J. Neurosci., March 15, 2002; 22(6): 2115 - 2124.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
V. C. Wheeler, C.-A. Gutekunst, V. Vrbanac, L.-A. Lebel, G. Schilling, S. Hersch, R. M. Friedlander, J. F. Gusella, J.-P. Vonsattel, D. R. Borchelt, et al.
Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice
Hum. Mol. Genet., March 1, 2002; 11(6): 633 - 640.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. Liu, G. Wang, and A. G. Yakovlev
Identification and Functional Analysis of the Rat Caspase-3 Gene Promoter
J. Biol. Chem., March 1, 2002; 277(10): 8273 - 8278.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Sun, K. Jin, X. O. Mao, Y. Zhu, and D. A. Greenberg
Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic injury
PNAS, December 6, 2001; (2001) 251466698.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Plesnila, S. Zinkel, D. A. Le, S. Amin-Hanjani, Y. Wu, J. Qiu, A. Chiarugi, S. S. Thomas, D. S. Kohane, S. J. Korsmeyer, et al.
BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia
PNAS, December 6, 2001; (2001) 261323298.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
Y. Morita-Fujimura, M. Fujimura, T. Yoshimoto, and P. H. Chan
Superoxide During Reperfusion Contributes to Caspase-8 Expression and Apoptosis After Transient Focal Stroke
Stroke, October 1, 2001; 32(10): 2356 - 2361.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Benchoua, C. Guegan, C. Couriaud, H. Hosseini, N. Sampaio, D. Morin, and B. Onteniente
Specific Caspase Pathways Are Activated in the Two Stages of Cerebral Infarction
J. Neurosci., September 15, 2001; 21(18): 7127 - 7134.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Namura, K. Iihara, S. Takami, I. Nagata, H. Kikuchi, K. Matsushita, M. A. Moskowitz, J. V. Bonventre, and A. Alessandrini
Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia
PNAS, August 10, 2001; (2001) 181213498.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
S. Namura, I. Nagata, S. Takami, H. Masayasu, and H. Kikuchi
Ebselen Reduces Cytochrome c Release From Mitochondria and Subsequent DNA Fragmentation After Transient Focal Cerebral Ischemia in Mice
Stroke, August 1, 2001; 32(8): 1906 - 1911.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Cao, W. Pei, J. Lan, R. A. Stetler, Y. Luo, T. Nagayama, S. H. Graham, X.-M. Yin, R. P. Simon, and J. Chen
Caspase-Activated DNase/DNA Fragmentation Factor 40 Mediates Apoptotic DNA Fragmentation in Transient Cerebral Ischemia and in Neuronal Cultures
J. Neurosci., July 1, 2001; 21(13): 4678 - 4690.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Bachis, A. M. Colangelo, S. Vicini, P. P. Doe, M. A. De Bernardi, G. Brooker, and I. Mocchetti
Interleukin-10 Prevents Glutamate-Mediated Cerebellar Granule Cell Death by Blocking Caspase-3-Like Activity
J. Neurosci., May 1, 2001; 21(9): 3104 - 3112.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
P. G. Matz, M. Fujimura, A. Lewen, Y. Morita-Fujimura, and P. H. Chan
Increased Cytochrome c-Mediated DNA Fragmentation and Cell Death in Manganese-Superoxide Dismutase-Deficient Mice After Exposure to Subarachnoid Hemolysate
Stroke, February 1, 2001; 32(2): 506 - 515.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Vukosavic, L. Stefanis, V. Jackson-Lewis, C. Guegan, N. Romero, C. Chen, M. Dubois-Dauphin, and S. Przedborski
Delaying Caspase Activation by Bcl-2: A Clue to Disease Retardation in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
J. Neurosci., December 15, 2000; 20(24): 9119 - 9125.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. Pasinelli, M. K. Houseweart, R. H. Brown Jr., and D. W. Cleveland
Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis
PNAS, November 22, 2000; (2000) 240305897.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Vaudry, B. J. Gonzalez, M. Basille, T. F. Pamantung, M. Fontaine, A. Fournier, and H. Vaudry
The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32
PNAS, November 21, 2000; 97(24): 13390 - 13395.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
W. Nakajima, A. Ishida, M. S. Lange, K. L. Gabrielson, M. A. Wilson, L. J. Martin, M. E. Blue, and M. V. Johnston
Apoptosis Has a Prolonged Role in the Neurodegeneration after Hypoxic Ischemia in the Newborn Rat
J. Neurosci., November 1, 2000; 20(21): 7994 - 8004.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. E. Springer, R. D. Azbill, S. A. Nottingham, and S. E. Kennedy
Calcineurin-Mediated BAD Dephosphorylation Activates the Caspase-3 Apoptotic Cascade in Traumatic Spinal Cord Injury
J. Neurosci., October 1, 2000; 20(19): 7246 - 7251.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
P. G. Matz, J.-C. Copin, P. H. Chan, and R. L. Macdonald
Cell Death After Exposure to Subarachnoid Hemolysate Correlates Inversely With Expression of CuZn-Superoxide Dismutase Editorial Comment
Stroke, October 1, 2000; 31(10): 2450 - 2459.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. Matsushita, Y. Wu, J. Qiu, L. Lang-Lazdunski, L. Hirt, C. Waeber, B. T. Hyman, J. Yuan, and M. A. Moskowitz
Fas Receptor and Neuronal Cell Death after Spinal Cord Ischemia
J. Neurosci., September 15, 2000; 20(18): 6879 - 6887.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
T. Nakagawa and J. Yuan
Cross-talk between Two Cysteine Protease Families: Activation of Caspase-12 by Calpain in Apoptosis
J. Cell Biol., August 21, 2000; 150(4): 887 - 894.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
D. C. Henshall, R. S. B. Clark, P. D. Adelson, M. Chen, S. C. Watkins, and R. P. Simon
Alterations in bcl-2 and caspase gene family protein expression in human temporal lobe epilepsy
Neurology, July 25, 2000; 55(2): 250 - 257.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
P. M. Kang, A. Haunstetter, H. Aoki, A. Usheva, and S. Izumo
Morphological and Molecular Characterization of Adult Cardiomyocyte Apoptosis During Hypoxia and Reoxygenation
Circ. Res., July 21, 2000; 87(2): 118 - 125.
[Abstract] [Full Text] [PDF]