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The Journal of Neuroscience, May 15, 1998, 18(10):3757-3766
Removal of Polysialic Acid-Neural Cell Adhesion Molecule Induces
Aberrant Mossy Fiber Innervation and Ectopic Synaptogenesis in the
Hippocampus
Tatsunori
Seki1 and
Urs
Rutishauser2
Departments of 1 Neurosciences and
2 Genetics, Case Western Reserve University, Cleveland,
Ohio 44106
The mossy fiber axons of both the developing and adult dentate
gyrus express the highly polysialylated form of neural cell adhesion
molecule (NCAM) as they innervate the proximal apical dendrites of
pyramidal cells in the CA3 region of the hippocampus. The present study
used polysialic acid (PSA)-deficient and NCAM mutant mice to evaluate
the role of PSA in mossy fiber development. The results indicate that
removal of PSA by either specific enzymatic degradation or mutation of
the NCAM-180 isoform that carries PSA in the brain causes an aberrant
and persistent innervation of the pyramidal cell layer by mossy fibers,
including excessive collateral sprouting and/or defasciculation of
these processes, as well as formation of ectopic mossy fiber synaptic
boutons. These results are considered in terms of two possible effects of PSA removal: an increase in the number of mossy fibers that can grow
into the pyramidal cell layer and an inhibition of process retraction
by formation of stable junctions including synapses. As these defects
on granule cells in the adult animal and PSA-positive granule cells
continue to be produced in the mature brain, the present findings may
be relevant to previous studies suggesting that PSA-NCAM function
is required for long-term potentiation, long-term depression, and
learning behaviors associated with hippocampus.
Key words:
hippocampal development; polysialic acid; neural cell
adhesion molecule; mossy fiber innervation; mossy fiber synaptogenesis; dentate gyrus
Copyright © 1998 Society for Neuroscience 0270-6474/98/18103757-10$05.00/0
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