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The Journal of Neuroscience, May 15, 1998, 18(10):3977-3989
Compartmentalization of Information Processing in an
Aplysia Feeding Circuit Interneuron through Membrane
Properties and Synaptic Interactions
Ray
Perrins and
Klaudiusz R.
Weiss
Department of Physiology and Biophysics, Mount Sinai School of
Medicine, Mount Sinai Medical Center, New York, New York 10029-6574
We describe a pair of cerebral-to-buccal interneurons, CBI-5/6,
which have outputs and inputs in two ganglia. The soma in the cerebral
ganglion received synaptic inputs during buccal motor programs (BMPs)
and after mechanical stimulation of the lips. During BMPs the soma
received antidromic spikes generated in processes in the buccal
ganglion. The soma was driven into a plateau potential by each of these
inputs, during which it fired orthodromically at 0-5 Hz. The soma had
outputs in the cerebral ganglion consisting of electrical coupling to
the adjacent CBI-5/6 and to a cerebral-to-pedal neuron (CPN1). The
buccal terminals of CBI-5/6 received inputs that generated rhythmic
barrages (up to 25 Hz) of antidromic spikes during BMPs. The buccal
terminals had chemical and electrical outputs to motor and premotor
elements of feeding circuitry. This combination of synaptic
interactions and endogenous properties mean that CBI-5/6 can process
information in a number of ways. During the barrage of antidromic
spikes, high-frequency firing will produce strong inputs to buccal
followers and on their arrival at the soma will transfer excitation
electrotonically to CPN1. Subthreshold input to the soma will be
transferred electrotonically to cerebral followers but will not be
relayed to postsynaptic buccal neurons. Plateau potentials after the
antidromic spikes or local cerebral inputs will locally excite CPN1 via
electrical coupling but will have little influence on buccal events
because of the low orthodromic firing rate. Thus, CBI-5/6 may transmit information locally within the cerebral ganglion or more extensively in
both buccal and cerebral ganglia simultaneously.
Key words:
plateau potential; feeding; mollusk; motor program; central pattern generator; Aplysia
Copyright © 1998 Society for Neuroscience 0270-6474/98/18103977-13$05.00/0
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