 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, June 15, 1998, 18(12):4758-4766
Aversive and Appetitive Events Evoke the Release of Corticotropin-Releasing Hormone and Bombesin-Like Peptides at the Central Nucleus of the Amygdala
Zul Merali1, 2, Judy McIntosh1, Pamela Kent1, David Michaud1, and Hymie Anisman3 1 School of Psychology and 2 Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5, and 3 Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada K1S 5B6
There is wide agreement that corticotropin-releasing hormone (CRH) systems within the brain are activated by stressful stimuli. There is also mounting evidence for the role of bombesin (BN)-like peptides in the mediation of the stress response. To date, however, the extent to which other stimuli increase the activity of these peptidergic systems has received little attention. In the present investigation we validated and used in vivo microdialysis sampling followed by ex vivo radioimmunoassays to monitor the release of CRH and BN-like peptides during appetitive (food intake) and stressful (restraint) events. It is demonstrated for the first time that the in vivo release of CRH and BN-like peptides at the central nucleus of the amygdala was markedly increased by both stressor exposure and food ingestion. In fact, the meal-elicited rise of CRH release was as great as that associated with 20 min of restraint stress. Paralleling these findings, circulating ACTH and corticosterone levels were also increased in response to both food intake and restraint. Contrary to the current views, these results indicate that either food ingestion is interpreted as a "stressful" event by certain neural circuits involving the central amygdala or that the CRH- and BN-related peptidergic systems may serve a much broader role than previously envisioned. Rather than evoking feelings of fear and anxiety, these systems may serve to draw attention to events or cues of biological significance, such as those associated with food availability as well as those posing a threat to survival.
Key words: corticotropin-releasing factor; gastrin-releasing peptide; neuromedin C; restraint stress; reward; feeding; eating disorders; stress
Copyright © 1998 Society for Neuroscience 0270-6474/98/18124758-09$05.00/0
This article has been cited by other articles:
M. Yao, J. Schulkin, and R. J. Denver
Evolutionarily Conserved Glucocorticoid Regulation of Corticotropin-Releasing Factor Expression
Endocrinology, May 1, 2008; 149(5): 2352 - 2360.
[Abstract] [Full Text] [PDF]
Y. Chen, C. M. Dube, C. J. Rice, and T. Z. Baram
Rapid Loss of Dendritic Spines after Stress Involves Derangement of Spine Dynamics by Corticotropin-Releasing Hormone
J. Neurosci., March 12, 2008; 28(11): 2903 - 2911.
[Abstract] [Full Text] [PDF]
Z. Merali, T. Bedard, N. Andrews, B. Davis, A. T. McKnight, M. I. Gonzalez, M. Pritchard, P. Kent, and H. Anisman
Bombesin Receptors as a Novel Anti-Anxiety Therapeutic Target: BB1 Receptor Actions on Anxiety through Alterations of Serotonin Activity
J. Neurosci., October 11, 2006; 26(41): 10387 - 10396.
[Abstract] [Full Text] [PDF]
O. Stiedl, M. Meyer, O. Jahn, S. O. Ogren, and J. Spiess
Corticotropin-Releasing Factor Receptor 1 and Central Heart Rate Regulation in Mice during Expression of Conditioned Fear
J. Pharmacol. Exp. Ther., March 1, 2005; 312(3): 905 - 916.
[Abstract] [Full Text] [PDF]
L. H. Corbit and B. W. Balleine
Double Dissociation of Basolateral and Central Amygdala Lesions on the General and Outcome-Specific Forms of Pavlovian-Instrumental Transfer
J. Neurosci., January 26, 2005; 25(4): 962 - 970.
[Abstract] [Full Text] [PDF]
V. B. Risbrough, R. L. Hauger, A. L. Roberts, W. W. Vale, and M. A. Geyer
Corticotropin-Releasing Factor Receptors CRF1 and CRF2 Exert Both Additive and Opposing Influences on Defensive Startle Behavior
J. Neurosci., July 21, 2004; 24(29): 6545 - 6552.
[Abstract] [Full Text] [PDF]
C. Schulz, K. Paulus, and H. Lehnert
Central Nervous and Metabolic Effects of Intranasally Applied Leptin
Endocrinology, June 1, 2004; 145(6): 2696 - 2701.
[Abstract] [Full Text] [PDF]
Z. Merali, L. Du, P. Hrdina, M. Palkovits, G. Faludi, M. O. Poulter, and H. Anisman
Dysregulation in the Suicide Brain: mRNA Expression of Corticotropin-Releasing Hormone Receptors and GABAA Receptor Subunits in Frontal Cortical Brain Region
J. Neurosci., February 11, 2004; 24(6): 1478 - 1485.
[Abstract] [Full Text] [PDF]
J. L. Fudge and A. B. Emiliano
The Extended Amygdala and the Dopamine System: Another Piece of the Dopamine Puzzle
J Neuropsychiatry Clin Neurosci, August 1, 2003; 15(3): 306 - 316.
[Abstract] [Full Text]
K. D. Laugero, F. Gomez, S. Manalo, and M. F. Dallman
Corticosterone Infused Intracerebroventricularly Inhibits Energy Storage and Stimulates the Hypothalamo-Pituitary Axis in Adrenalectomized Rats Drinking Sucrose
Endocrinology, December 1, 2002; 143(12): 4552 - 4562.
[Abstract] [Full Text] [PDF]
B. Roozendaal, K. L. Brunson, B. L. Holloway, J. L. McGaugh, and T. Z. Baram
Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation
PNAS, October 15, 2002; 99(21): 13908 - 13913.
[Abstract] [Full Text] [PDF]
S. C. Stout, M. J. Owens, and C. B. Nemeroff
Regulation of Corticotropin-Releasing Factor Neuronal Systems and Hypothalamic-Pituitary-Adrenal Axis Activity by Stress and Chronic Antidepressant Treatment
J. Pharmacol. Exp. Ther., March 1, 2002; 300(3): 1085 - 1092.
[Abstract] [Full Text] [PDF]
Y. Chen, R. A. Bender, M. Frotscher, and T. Z. Baram
Novel and Transient Populations of Corticotropin-Releasing Hormone-Expressing Neurons in Developing Hippocampus Suggest Unique Functional Roles: A Quantitative Spatiotemporal Analysis
J. Neurosci., September 15, 2001; 21(18): 7171 - 7181.
[Abstract] [Full Text] [PDF]
K. D. Laugero, M. E. Bell, S. Bhatnagar, L. Soriano, and M. F. Dallman
Sucrose Ingestion Normalizes Central Expression of Corticotropin-Releasing-Factor Messenger Ribonucleic Acid and Energy Balance in Adrenalectomized Rats: A Glucocorticoid-Metabolic-Brain Axis?
Endocrinology, July 1, 2001; 142(7): 2796 - 2804.
[Abstract] [Full Text] [PDF]
H. Nishijo, T. Ono, T. Uwano, T. Kondoh, and K. Torii
Hypothalamic and Amygdalar Neuronal Responses to Various Tastant Solutions during Ingestive Behavior in Rats
J. Nutr., April 1, 2000; 130(4): 954 - 954.
[Abstract] [Full Text]
A. W. Kusnecov, R. Liang, and G. Shurin
T-Lymphocyte Activation Increases Hypothalamic and Amygdaloid Expression of CRH mRNA and Emotional Reactivity to Novelty
J. Neurosci., June 1, 1999; 19(11): 4533 - 4543.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|