 |
 Previous Article
The Journal of Neuroscience, June 15, 1998, 18(12):4800-4813
Substance P Modulates NMDA Responses and Causes Long-Term Protein
Synthesis-Dependent Modulation of the Lamprey Locomotor Network
David
Parker,
Weiqi
Zhang, and
Sten
Grillner
The Nobel Institute for Neurophysiology, Department of
Neuroscience, Karolinska Institute, S 17177, Stockholm, Sweden
Tachykinin immunoreactivity is found in a ventromedial spinal
plexus in the lamprey. Neurons in this plexus project bilaterally and
are thus in a position to modulate locomotor networks on both sides of
the spinal cord. We have examined the effects of the tachykinin
substance P on NMDA-evoked locomotor activity. Brief (10 min)
application of tachykinin neuropeptides results in a prolonged
concentration-dependent (>24 hr) modulation of locomotor activity,
shown by the increased burst frequency and more regular burst activity.
These effects are blocked by the tachykinin antagonist spantide II.
There are at least two phases to the burst frequency modulation. An
initial phase (~2 hr) is associated with the protein kinase C-dependent potentiation of cellular responses to NMDA. The
long-lasting phase (>2 hr) appears to be protein synthesis-dependent,
with protein synthesis inhibitors causing the increased burst frequency to recover after washing for 2-3 hr. The modulation of the burst regularity is caused by a separate effect of tachykinins, because unlike the burst frequency modulation it does not require the modulation of NMDA receptors for its induction and is blocked by H8, an
inhibitor of cAMP- and cGMP-dependent protein kinases. The effects of
substance P were mimicked by the dopamine D2 receptor antagonist
eticlopride. The effects of eticlopride were blocked by the tachykinin
antagonist spantide II, suggesting that eticlopride may endogenously
release tachykinins. Because locomotor activity in vitro
corresponds to that during swimming in intact animals, we suggest that
endogenously released tachykinins will result in prolonged modulation
of locomotor behavior.
Key words:
neuropeptide; substance P; dopamine; neuromodulation; locomotor network; protein synthesis
Copyright © 1998 Society for Neuroscience 0270-6474/98/18124800-14$05.00/0
This article has been cited by other articles:
|
|
|
|
 
C. Thorn Perez, R. H. Hill, A. El. Manira, and S. Grillner
Endocannabinoids Mediate Tachykinin-Induced Effects in the Lamprey Locomotor Network
J Neurophysiol,
September 1, 2009;
102(3):
1358 - 1365.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. T. Perez, R. H. Hill, and S. Grillner
Endogenous Tachykinin Release Contributes to the Locomotor Activity in Lamprey
J Neurophysiol,
May 1, 2007;
97(5):
3331 - 3339.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Parker and S. Bevan
Modulation of Cellular and Synaptic Variability in the Lamprey Spinal Cord
J Neurophysiol,
January 1, 2007;
97(1):
44 - 56.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Parker
Complexities and uncertainties of neuronal network function
Phil Trans R Soc B,
January 29, 2006;
361(1465):
81 - 99.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Brocard, C. Bardy, and R. Dubuc
Modulatory Effect of Substance P to the Brain Stem Locomotor Command in Lampreys
J Neurophysiol,
April 1, 2005;
93(4):
2127 - 2141.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Bevan and D. Parker
Metaplastic Facilitation and Ultrastructural Changes in Synaptic Properties Are Associated with Long-Term Modulation of the Lamprey Locomotor Network
J. Neurosci.,
October 20, 2004;
24(42):
9458 - 9468.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Vink, J. J. Donkin, M. I. Cruz, A. J Nimmo, and I. Cernak
A Substance P Antagonist Increases Brain Intracellular Free Magnesium Concentration after Diffuse Traumatic Brain Injury in Rats
J. Am. Coll. Nutr.,
October 1, 2004;
23(5):
538S - 540S.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Quinlan, P. G. Placas, and J. T. Buchanan
Cholinergic Modulation of the Locomotor Network in the Lamprey Spinal Cord
J Neurophysiol,
September 1, 2004;
92(3):
1536 - 1548.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Alford, E. Schwartz, and G. V. Di Prisco
The Pharmacology of Vertebrate Spinal Central Pattern Generators
Neuroscientist,
June 1, 2003;
9(3):
217 - 228.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. Chau, N. Giroux, H. Barbeau, L. Jordan, and S. Rossignol
Effects of Intrathecal Glutamatergic Drugs on Locomotion I. NMDA in Short-Term Spinal Cats
J Neurophysiol,
December 1, 2002;
88(6):
3032 - 3045.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Telgkamp, Y. Q. Cao, A. I. Basbaum, and J.-M. Ramirez
Long-Term Deprivation of Substance P in PPT-A Mutant Mice Alters the Anoxic Response of the Isolated Respiratory Network
J Neurophysiol,
July 1, 2002;
88(1):
206 - 213.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Blitz and J.-M. Ramirez
Long-Term Modulation of Respiratory Network Activity Following Anoxia In Vitro
J Neurophysiol,
June 1, 2002;
87(6):
2964 - 2971.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Svensson, S. Grillner, and D. Parker
Synaptically Evoked Membrane Potential Oscillations Induced by Substance P in Lamprey Motor Neurons
J Neurophysiol,
January 1, 2002;
87(1):
113 - 121.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Marchetti and A. Nistri
Neuronal Bursting Induced by NK3 Receptor Activation in the Neonatal Rat Spinal Cord In Vitro
J Neurophysiol,
December 1, 2001;
86(6):
2939 - 2950.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. N. MacLean and B. J. Schmidt
Voltage-Sensitivity of Motoneuron NMDA Receptor Channels Is Modulated by Serotonin in the Neonatal Rat Spinal Cord
J Neurophysiol,
September 1, 2001;
86(3):
1131 - 1138.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Svensson, S. Grillner, and D. Parker
Gating and Braking of Short- and Long-Term Modulatory Effects by Interactions between Colocalized Neuromodulators
J. Neurosci.,
August 15, 2001;
21(16):
5984 - 5992.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Grillner, P. Wallen, R. Hill, L. Cangiano, and A. E. Manira
Ion channels of importance for the locomotor pattern generation in the lamprey brainstem-spinal cord
J. Physiol.,
May 15, 2001;
533(1):
23 - 30.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Buschges, M. A. Wikstrom, S. Grillner, and A. El Manira
Roles of High-Voltage-Activated Calcium Channel Subtypes in a Vertebrate Spinal Locomotor Network
J Neurophysiol,
December 1, 2000;
84(6):
2758 - 2766.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. El Manira and P. Wallen
Mechanisms of Modulation of a Neural Network
Physiology,
August 1, 2000;
15(4):
186 - 191.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Parker
Presynaptic and Interactive Peptidergic Modulation of Reticulospinal Synaptic Inputs in the Lamprey
J Neurophysiol,
May 1, 2000;
83(5):
2497 - 2507.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Parker
Activity and Calcium-Dependent Mechanisms Maintain Reliable Interneuron Synaptic Transmission in a Rhythmic Neural Network
J. Neurosci.,
March 1, 2000;
20(5):
1754 - 1766.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ullstrom, D. Parker, E. Svensson, and S. Grillner
Neuropeptide-Mediated Facilitation and Inhibition of Sensory Inputs and Spinal Cord Reflexes in the Lamprey
J Neurophysiol,
April 1, 1999;
81(4):
1730 - 1740.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Parker and S. Grillner
Activity-Dependent Metaplasticity of Inhibitory and Excitatory Synaptic Transmission in the Lamprey Spinal Cord Locomotor Network
J. Neurosci.,
March 1, 1999;
19(5):
1647 - 1656.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Parker and S. Grillner
Cellular and Synaptic Modulation Underlying Substance P-Mediated Plasticity of the Lamprey Locomotor Network
J. Neurosci.,
October 1, 1998;
18(19):
8095 - 8110.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
