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The Journal of Neuroscience, July 1, 1998, 18(13):4985-4992

Localized Synaptic Actions of Neurotrophin-4

Xin-hao Wang, Benedikt Berninger, and Mu-ming Poo

Department of Biology, University of California at San Diego, La Jolla, California 92093-0357

Neurotrophins secreted by the postsynaptic target cell may participate in activity-dependent synaptic modification during development and in the mature brain. A fundamental question of how neurotrophins can sculpt synaptic connections is whether neurotrophin-induced synaptic changes are spatially restricted to the site of neurotrophin secretion or whether they can spread to neighboring synapses. Using a model system of nerve-muscle coculture in which neurotrophin-4 (NT-4) is overexpressed in a subpopulation of postsynaptic myocytes, we demonstrated that presynaptic potentiation is restricted to synapses on myocytes overexpressing NT-4 without affecting nearby synapses formed by the same neuron on control myocytes. Likewise, postsynaptic modulation of acetylcholine channels by secreted NT-4 is spatially restricted to <60 µm from the site of NT-4 secretion. Therefore, activity-dependent secretion of neurotrophins can result in highly localized modification of neuronal connections.

Key words: Xenopus; synaptic transmission; neuromuscular junction; embryo injection; acetylcholine receptor; TrkB receptor

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Copyright © 1998 Society for Neuroscience  0270-6474/98/18134985-08$05.00/0

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