 |
 Previous Article
The Journal of Neuroscience, July 1, 1998, 18(13):5095-5102
Electrophysiology of the Hippocampal and Amygdaloid Projections
to the Nucleus Accumbens of the Rat: Convergence, Segregation, and
Interaction of Inputs
Antonius B.
Mulder,
Martijn
Gijsberti
Hodenpijl, and
Fernando H.
Lopes da
Silva
Graduate School for Neurosciences, Institute of Neurobiology,
Faculty of Biology, University of Amsterdam, 1098 SM Amsterdam, The
Netherlands
The nucleus accumbens (Nacb) receives inputs from hippocampus and
amygdala but it is still unclear how these inputs are functionally organized and may interact. The interplay between these input pathways
was examined using electrophysiological tools in the rat, in
vivo, under halothane anesthesia. After fornix/fimbria stimulation (Fo/Fi, subicular projection fibers to the Nacb), mono- and
polysynaptically driven single units were recorded in the medial
shell/core regions of the Nacb and in the ventromedial caudate putamen.
Monosynaptically driven neurons by basolateral amygdala (BLA)
stimulation were found in the medial shell/core and in the
ventrolateral shell/core regions. In the areas of convergence (medial
shell/core), paired activation of BLA followed by that of Fo/Fi
resulted in an enhancement of the Fo/Fi response, whereas stimulation
in the reverse order, Fo/Fi followed by BLA, led to a depression of the
BLA response. In addition to these patterns of interactions, the
tetanization of the Fo/Fi to Nacb pathway caused a homosynaptic
decremental (long-term) potentiation in the Nacb, accompanied by a
heterosynaptic (long-term) depression of the nontetanized BLA to Nacb
pathway. We postulate that the hippocampal inputs may close a
"gate" for the amygdala inputs, whereas the gate is opened for the
hippocampus inputs by previous amygdalar activity. These opposite
effects on the Nacb neuronal populations should be taken into account
when interpreting behavioral phenomena, particularly with respect to
the contrasting effects of the amygdala and the hippocampus in
locomotion and place learning.
Key words:
nucleus accumbens; basolateral amygdala; hippocampus; limbic system; homosynaptic LTP; heterosynaptic LTD; paired-pulse
facilitation; single unit; rat
Copyright © 1998 Society for Neuroscience 0270-6474/98/18135095-08$05.00/0
This article has been cited by other articles:
|
|
|
|
 
V. B. McGinty and A. A. Grace
Timing-Dependent Regulation of Evoked Spiking in Nucleus Accumbens Neurons by Integration of Limbic and Prefrontal Cortical Inputs
J Neurophysiol,
April 1, 2009;
101(4):
1823 - 1835.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Manago, C. Castellano, A. Oliverio, A. Mele, and E. De Leonibus
Role of dopamine receptors subtypes, D1-like and D2-like, within the nucleus accumbens subregions, core and shell, on memory consolidation in the one-trial inhibitory avoidance task
Learn. Mem.,
December 30, 2008;
16(1):
46 - 52.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Belujon and A. A. Grace
Critical Role of the Prefrontal Cortex in the Regulation of Hippocampus-Accumbens Information Flow
J. Neurosci.,
September 24, 2008;
28(39):
9797 - 9805.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Faure, S. M. Reynolds, J. M. Richard, and K. C. Berridge
Mesolimbic Dopamine in Desire and Dread: Enabling Motivation to Be Generated by Localized Glutamate Disruptions in Nucleus Accumbens
J. Neurosci.,
July 9, 2008;
28(28):
7184 - 7192.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Ito, T. W. Robbins, C. M. Pennartz, and B. J. Everitt
Functional Interaction between the Hippocampus and Nucleus Accumbens Shell Is Necessary for the Acquisition of Appetitive Spatial Context Conditioning
J. Neurosci.,
July 2, 2008;
28(27):
6950 - 6959.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Ishikawa, F. Ambroggi, S. M. Nicola, and H. L. Fields
Dorsomedial Prefrontal Cortex Contribution to Behavioral and Nucleus Accumbens Neuronal Responses to Incentive Cues
J. Neurosci.,
May 7, 2008;
28(19):
5088 - 5098.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. G. Carter, G. J. Soler-Llavina, and B. L. Sabatini
Timing and Location of Synaptic Inputs Determine Modes of Subthreshold Integration in Striatal Medium Spiny Neurons
J. Neurosci.,
August 15, 2007;
27(33):
8967 - 8977.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Hunt, K. Kessal, and R. Garcia
Ketamine Induces Dopamine-Dependent Depression of Evoked Hippocampal Activity in the Nucleus Accumbens in Freely Moving Rats
J. Neurosci.,
January 12, 2005;
25(2):
524 - 531.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Sarter, C. L Nelson, and J. P Bruno
Cortical Cholinergic Transmission and Cortical Information Processing in Schizophrenia
Schizophr Bull,
January 1, 2005;
31(1):
117 - 138.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. A. Pennartz, E. Lee, J. Verheul, P. Lipa, C. A. Barnes, and B. L. McNaughton
The Ventral Striatum in Off-Line Processing: Ensemble Reactivation during Sleep and Modulation by Hippocampal Ripples
J. Neurosci.,
July 21, 2004;
24(29):
6446 - 6456.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Nicola, I. A. Yun, K. T. Wakabayashi, and H. L. Fields
Cue-Evoked Firing of Nucleus Accumbens Neurons Encodes Motivational Significance During a Discriminative Stimulus Task
J Neurophysiol,
April 1, 2004;
91(4):
1840 - 1865.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Hugues, K. Kessal, M. J. Hunt, and R. Garcia
A Conditioned Stressful Environment Causes Short-Term Metaplastic-Like Changes in the Rat Nucleus Accumbens
J Neurophysiol,
November 1, 2003;
90(5):
3224 - 3231.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. E. Ghitza, A. T. Fabbricatore, V. Prokopenko, A. P. Pawlak, and M. O. West
Persistent Cue-Evoked Activity of Accumbens Neurons after Prolonged Abstinence from Self-Administered Cocaine
J. Neurosci.,
August 13, 2003;
23(19):
7239 - 7245.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Reynolds and K. C. Berridge
Positive and Negative Motivation in Nucleus Accumbens Shell: Bivalent Rostrocaudal Gradients for GABA-Elicited Eating, Taste "Liking"/"Disliking" Reactions, Place Preference/Avoidance, and Fear
J. Neurosci.,
August 15, 2002;
22(16):
7308 - 7320.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. Kelley and K. C. Berridge
The Neuroscience of Natural Rewards: Relevance to Addictive Drugs
J. Neurosci.,
May 1, 2002;
22(9):
3306 - 3311.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. B. Floresco, C. D. Blaha, C. R. Yang, and A. G. Phillips
Modulation of Hippocampal and Amygdalar-Evoked Activity of Nucleus Accumbens Neurons by Dopamine: Cellular Mechanisms of Input Selection
J. Neurosci.,
April 15, 2001;
21(8):
2851 - 2860.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Roozendaal, D. J.-F. de Quervain, B. Ferry, B. Setlow, and J. L. McGaugh
Basolateral Amygdala-Nucleus Accumbens Interactions in Mediating Glucocorticoid Enhancement of Memory Consolidation
J. Neurosci.,
April 1, 2001;
21(7):
2518 - 2525.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. L. Thomas and B. J. Everitt
Limbic-Cortical-Ventral Striatal Activation during Retrieval of a Discrete Cocaine-Associated Stimulus: A Cellular Imaging Study with {gamma} Protein Kinase C Expression
J. Neurosci.,
April 1, 2001;
21(7):
2526 - 2535.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. T. Williams, M. J. Christie, and O. Manzoni
Cellular and Synaptic Adaptations Mediating Opioid Dependence
Physiol Rev,
January 1, 2001;
81(1):
299 - 343.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Roozendaal, B. T. Nguyen, A. E. Power, and J. L. McGaugh
Basolateral amygdala noradrenergic influence enables enhancement of memory consolidation induced by hippocampal glucocorticoid receptor activation
PNAS,
September 28, 1999;
96(20):
11642 - 11647.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
