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The Journal of Neuroscience, July 15, 1998, 18(14):5366-5373
Type 1 Inositol 1,4,5-Trisphosphate Receptor Is Required for Induction of Long-Term Depression in Cerebellar Purkinje Neurons
Takafumi Inoue1, Kunio Kato2, Kazuhisa Kohda1, and Katsuhiko Mikoshiba1, 2, 3 1 Department of Molecular Neurobiology, The Institute of Medical Science, The University of Tokyo, Tokyo-108, Japan, 2 Mikoshiba Calciosignal Net Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Corporation (JST), Tokyo-153, Japan, and 3 Developmental Neurobiology Laboratory, Brain Science Institute, The Institute of Physical and Chemical Research (RIKEN), Wako-shi, Saitama, Japan
The inositol 1,4,5-trisphosphate receptor (InsP3R) is an intracellular Ca2+ channel that releases Ca2+ from internal Ca2+ stores in response to InsP3. Although InsP3R is highly expressed in various regions of the mammalian brain, the functional role of this receptor has not been clarified. We show here that cerebellar slices prepared from mice with a disrupted InsP3R type 1 gene, which is predominantly expressed in Purkinje cells, completely lack long-term depression (LTD), a model of synaptic plasticity in the cerebellum. Moreover, a specific antibody against InsP3R1, introduced into wild-type Purkinje cells through patch pipettes, blocked the induction of LTD. These data indicate that, in addition to Ca2+ influx through Ca2+ channels on the plasma membrane, Ca2+ release from InsP3R plays an essential role in the induction of LTD, suggesting a physiological importance for InsP3R in Purkinje cells.
Key words: type 1 inositol 1,4,5-trisphosphate receptor; long-term depression; cerebellar Purkinje neuron; synaptic plasticity; brain slice; patch recording; caged-InsP3
Copyright © 1998 Society for Neuroscience 0270-6474/98/18145366-08$05.00/0
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