QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (33) Citing Articles via Google Scholar Google Scholar Articles by Banner, L. R. Articles by Woolf, C. J. Search for Related Content PubMed PubMed Citation Articles by Banner, L. R. Articles by Woolf, C. J.

 Previous Article  |  Next Article 

The Journal of Neuroscience, July 15, 1998, 18(14):5456-5462

Leukemia Inhibitory Factor Is an Anti-Inflammatory and Analgesic Cytokine

Lisa R. Banner¹, Paul H. Patterson¹, Andrew Allchorne², Steve Poole³, and Clifford J. Woolf^{2, 4}

¹ Division of Biology, California Institute of Technology, Pasadena, California 91125, ² Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, England, ³ Division of Endocrinology, National Institute for Biological Standards and Control, Herts EN6 3QG, England, and ⁴ Department of Anesthesiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129

The mRNA for leukemia inhibitory factor (LIF), a neuroimmune signaling molecule, is elevated during skin inflammation produced by intraplantar injection of complete Freund's adjuvant (CFA). Moreover, although LIF knock-out mice display normal sensitivity to cutaneous mechanical and thermal stimulation compared with wild-type mice, the degree of CFA-induced inflammation in mice lacking LIF is enhanced in spatial extent, amplitude, cellular infiltrate, and interleukin (IL)-1 and nerve growth factor (NGF) expression. Conversely, local injection of low doses of recombinant LIF diminishes mechanical and thermal hypersensitivity as well as the IL-1 and NGF expression induced by CFA. These data show that upregulation of LIF during peripheral inflammation serves a key, early anti-inflammatory role and that exogenous LIF can reduce inflammatory hyperalgesia.

Key words: pain; inflammation; edema; hyperalgesia; primary sensory neuron; analgesia

---

Copyright © 1998 Society for Neuroscience  0270-6474/98/18145456-07$05.00/0

This article has been cited by other articles:

				R. A. Linker, N. Kruse, S. Israel, T. Wei, S. Seubert, A. Hombach, B. Holtmann, F. Luhder, R. M. Ransohoff, M. Sendtner, et al. Leukemia Inhibitory Factor Deficiency Modulates the Immune Response and Limits Autoimmune Demyelination: A New Role for Neurotrophic Cytokines in Neuroinflammation J. Immunol., February 15, 2008; 180(4): 2204 - 2213. [Abstract] [Full Text] [PDF]

				Y. Morikawa, S. Tamura, K.-i. Minehata, P. J. Donovan, A. Miyajima, and E. Senba Essential Function of Oncostatin M in Nociceptive Neurons of Dorsal Root Ganglia J. Neurosci., February 25, 2004; 24(8): 1941 - 1947. [Abstract] [Full Text] [PDF]

				W. B. J. Cafferty, N. J. Gardiner, I. Gavazzi, J. Powell, S. B. McMahon, J. K. Heath, J. Munson, J. Cohen, and S. W. N. Thompson Leukemia Inhibitory Factor Determines the Growth Status of Injured Adult Sensory Neurons J. Neurosci., September 15, 2001; 21(18): 7161 - 7170. [Abstract] [Full Text] [PDF]

				M. Zhu, K. Oishi, S. Chul Lee, and P. H. Patterson Studies Using Leukemia Inhibitory Factor (LIF) Knockout Mice and a LIF Adenoviral Vector Demonstrate a Key Anti-Inflammatory Role for This Cytokine in Cutaneous Inflammation J. Immunol., February 1, 2001; 166(3): 2049 - 2054. [Abstract] [Full Text] [PDF]

				V. Chesnokova, A. Kariagina, and S. Melmed Opposing effects of pituitary leukemia inhibitory factor and SOCS-3 on the ACTH axis response to inflammation Am J Physiol Endocrinol Metab, May 1, 2002; 282(5): E1110 - E1118. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help