 |
||||
|
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, August 1, 1998, 18(15):5682-5691
Expression of Kv1.1, a Shaker-Like Potassium Channel, Is Temporally Regulated in Embryonic Neurons and Glia
Janice L. Hallows and Bruce L. Tempel The Virginia Merrill Bloedel Hearing Research Center and the Departments of Pharmacology and Otolaryngology-Head and Neck Surgery, University of Washington School of Medicine, Seattle, Washington 98195
Kv1.1, a Shaker-like voltage-gated potassium channel, is strongly expressed in a variety of neurons in adult rodents, in which it appears to be involved in regulating neuronal excitability. Here we show that Kv1.1 is also expressed during embryonic development in the mouse, exhibiting two transient peaks of expression around embryonic day 9.5 (E9.5) and E14.5. Using both in situ hybridization and immunocytochemistry, we have identified several cell types and tissues that express Kv1.1 RNA and protein. At E9.5, Kv1.1 RNA and protein are detected transiently in non-neuronal cells in several regions of the early CNS, including rhombomeres 3 and 5 and ventricular zones in the mesencephalon and diencephalon. At E14.5, several cell types in both the CNS and peripheral nervous system express Kv1.1, including neuronal cells (sensory ganglia and outer aspect of cerebral hemispheres) and glial cells (radial glia, satellite cells, and Schwann cell precursors). These data show that Kv1.1 is expressed transiently in a variety of neuronal and non-neuronal cells during restricted periods of embryonic development. Although the functional roles of Kv1.1 in development are not understood, the cell-specific localization and timing of expression suggest this channel may play a role in several developmental processes, including proliferation, migration, or cell-cell adhesion.
Key words: voltage-gated potassium channel; embryo; development; mouse; Kv1.1; glia; neuron; rhombomere; expression
Copyright © 1998 Society for Neuroscience 0270-6474/98/18155682-10$05.00/0
This article has been cited by other articles:
H. M. Brew, J. X. Gittelman, R. S. Silverstein, T. D. Hanks, V. P. Demas, L. C. Robinson, C. A. Robbins, J. McKee-Johnson, S. Y. Chiu, A. Messing, et al.
Seizures and Reduced Life Span in Mice Lacking the Potassium Channel Subunit Kv1.2, but Hypoexcitability and Enlarged Kv1 Currents in Auditory Neurons
J Neurophysiol, September 1, 2007; 98(3): 1501 - 1525.
[Abstract] [Full Text] [PDF]
M. A. Howard, R. M. Burger, and E. W Rubel
A Developmental Switch to GABAergic Inhibition Dependent on Increases in Kv1-Type K+ Currents
J. Neurosci., February 21, 2007; 27(8): 2112 - 2123.
[Abstract] [Full Text] [PDF]
S. Kourrich, C. Manrique, P. Salin, and C. Mourre
Transient hippocampal down-regulation of Kv1.1 subunit mRNA during associative learning in rats
Learn. Mem., September 1, 2005; 12(5): 511 - 519.
[Abstract] [Full Text] [PDF]
H. L. Picken Bahrey and W. J. Moody
Early Development of Voltage-Gated Ion Currents and Firing Properties in Neurons of the Mouse Cerebral Cortex
J Neurophysiol, April 1, 2003; 89(4): 1761 - 1773.
[Abstract] [Full Text] [PDF]
H. M Brew, J. L Hallows, and B. L Tempel
Hyperexcitability and reduced low threshold potassium currents in auditory neurons of mice lacking the channel subunit Kv1.1
J. Physiol., April 1, 2003; 548(1): 1 - 20.
[Abstract] [Full Text] [PDF]
H. L. P. Bahrey and W. J. Moody
Voltage-gated Currents, Dye and Electrical Coupling in the Embryonic Mouse Neocortex
Cereb Cortex, March 1, 2003; 13(3): 239 - 251.
[Abstract] [Full Text] [PDF]
J. P. Beekwilder, M. E. O'Leary, L. P. van den Broek, G. Th. H. Van Kempen, D. L. Ypey, and R. J. Van den Berg
Kv1.1 Channels of Dorsal Root Ganglion Neurons Are Inhibited by n-Butyl-p-aminobenzoate, a Promising Anesthetic for the Treatment of Chronic Pain
J. Pharmacol. Exp. Ther., February 1, 2003; 304(2): 531 - 538.
[Abstract] [Full Text] [PDF]
Z.-L. Mo, C. L Adamson, and R. L Davis
Dendrotoxin-sensitive K+ currents contribute to accommodation in murine spiral ganglion neurons
J. Physiol., August 1, 2002; 542(3): 763 - 778.
[Abstract] [Full Text] [PDF]
C. Mourre, M. N. Chernova, M.-F. Martin-Eauclaire, R. Bessone, G. Jacquet, M. Gola, Seth. L. Alper, and M. Crest
Distribution in Rat Brain of Binding Sites of Kaliotoxin, a Blocker of Kv1.1 and Kv1.3 alpha -Subunits
J. Pharmacol. Exp. Ther., December 1, 1999; 291(3): 943 - 952.
[Abstract] [Full Text]
S. Vassanelli and P. Fromherz
Transistor Probes Local Potassium Conductances in the Adhesion Region of Cultured Rat Hippocampal Neurons
J. Neurosci., August 15, 1999; 19(16): 6767 - 6773.
[Abstract] [Full Text] [PDF]
C. A. Ghiani, X. Yuan, A. M. Eisen, P. L. Knutson, R. A. DePinho, C. J. McBain, and V. Gallo
Voltage-Activated K+ Channels and Membrane Depolarization Regulate Accumulation of the Cyclin-Dependent Kinase Inhibitors p27Kip1 and p21CIP1 in Glial Progenitor Cells
J. Neurosci., July 1, 1999; 19(13): 5380 - 5392.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|