QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (27) Citing Articles via Google Scholar Google Scholar Articles by Frisén, J. Articles by Lindholm, D. Search for Related Content PubMed PubMed Citation Articles by Frisén, J. Articles by Lindholm, D. Pubmed/NCBI databases Substance via MeSH Medline Plus Health Information Scars Spinal Cord Injuries

 Previous Article  |  Next Article 

The Journal of Neuroscience, August 1, 1998, 18(15):5714-5722

Nerve Growth Factor Induces Process Formation in Meningeal Cells: Implications for Scar Formation in the Injured CNS

Jonas Frisén¹, Mårten Risling², Laura Korhonen³, Ute Zirrgiebel⁴, Clas B. Johansson^{1, 2}, Staffan Cullheim², and Dan Lindholm³

¹ Department of Cell and Molecular Biology, Medical Nobel Institute, and ² Department of Neuroscience, Karolinska Institute, S-171 77 Stockholm, Sweden, ³ Department of Developmental Neuroscience, Biomedical Center, S-751 23 Uppsala, Sweden, and ⁴ Brain Tumor Research Centre, Montreal Neurological Institute, Montreal, PQ, Canada, H3A 2B4

Nerve growth factor (NGF) induces the differentiation and supports the survival of subpopulations of neurons in the PNS and CNS. Here we report that meningeal cells in the pia mater express immunoreactivity and mRNA for both known NGF receptors, the low-affinity receptor p75 and the tyrosine kinase receptor trkA. NGF induces rapid tyrosine phosphorylation of trkA in meningeal cells in vitro. NGF does not stimulate proliferation of primary meningeal cells but induces process outgrowth. p75- and trkA-immunoreactive meningeal cells with long processes, resembling NGF-treated cells in vitro, are abundant in the scar tissue that forms at spinal cord lesions in rat and cat. These data suggest that NGF, which is expressed at increased levels in the brain and spinal cord after lesions, may be involved in scar formation in the injured CNS.

Key words: NGF; trkA; p75; injury; regeneration; meningeal cells

---

Copyright © 1998 Society for Neuroscience  0270-6474/98/18155714-09$05.00/0

This article has been cited by other articles:

				J. Widenfalk, K. Lundstromer, M. Jubran, S. Brene, and L. Olson Neurotrophic Factors and Receptors in the Immature and Adult Spinal Cord after Mechanical Injury or Kainic Acid J. Neurosci., May 15, 2001; 21(10): 3457 - 3475. [Abstract] [Full Text] [PDF]

				P.-A. Olsson, L. Korhonen, E. A. Mercer, and D. Lindholm MIR Is a Novel ERM-like Protein That Interacts with Myosin Regulatory Light Chain and Inhibits Neurite Outgrowth J. Biol. Chem., December 17, 1999; 274(51): 36288 - 36292. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help