QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (32) Citing Articles via Google Scholar Google Scholar Articles by Becker, T. Articles by Schachner, M. Search for Related Content PubMed PubMed Citation Articles by Becker, T. Articles by Schachner, M.

 Previous Article  |  Next Article 

The Journal of Neuroscience, August 1, 1998, 18(15):5789-5803

Readiness of Zebrafish Brain Neurons to Regenerate a Spinal Axon Correlates with Differential Expression of Specific Cell Recognition Molecules

Thomas Becker¹, Robert R. Bernhardt¹, Eva Reinhard³, Mario F. Wullimann², Enrico Tongiorgi¹, and Melitta Schachner^{1, 4}

¹ Department of Neurobiology, Swiss Federal Institute of Technology, Hönggerberg, CH-8093 Zürich, Switzerland, ² Brain Research Institute, University of Bremen, D-28334 Bremen, Germany, ³ Department of Pharmacology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland, and ⁴ Zentrum für Molekulare Neurobiologie Hamburg, Universität Hamburg, D-20246 Hamburg, Germany

We analyzed changes in the expression of mRNAs for the axonal growth-promoting cell recognition molecules L1.1, L1.2, and neural cell adhesion molecule (NCAM) after a rostral (proximal) or caudal (distal) spinal cord transection in adult zebrafish. One class of cerebrospinal projection nuclei (represented by the nucleus of the medial longitudinal fascicle, the intermediate reticular formation, and the magnocellular octaval nucleus) showed a robust regenerative response after both types of lesions as determined by retrograde tracing and/or in situ hybridization for GAP-43. A second class (represented by the nucleus ruber, the nucleus of the lateral lemniscus, and the tangential nucleus) showed a regenerative response only after proximal lesion. After distal lesion, upregulation of L1.1 and L1.2 mRNAs, but not NCAM mRNA expression, was observed in the first class of nuclei. The second class of nuclei did not show any changes in their mRNA expression after distal lesion. After proximal lesion, both classes of brain nuclei upregulated L1.1 mRNA expression (L1.2 and NCAM were not tested after proximal lesion). In the glial environment distal to the spinal lesion, labeling for L1.2 mRNA but not L1.1 or NCAM mRNAs was increased. These results, combined with findings in the lesioned retinotectal system of zebrafish (), indicate that the neuron-intrinsic regulation of cell recognition molecules after axotomy depends on the cell type as well as on the proximity of the lesion to the neuronal soma. Glial reactions differ for different regions of the CNS.

Key words: CNS regeneration; teleost; Mauthner cell; L1; NCAM; axotomy

---

Copyright © 1998 Society for Neuroscience  0270-6474/98/18155789-15$05.00/0

This article has been cited by other articles:

				C. G. Becker, B. C. Lieberoth, F. Morellini, J. Feldner, T. Becker, and M. Schachner L1.1 Is Involved in Spinal Cord Regeneration in Adult Zebrafish J. Neurosci., September 8, 2004; 24(36): 7837 - 7842. [Abstract] [Full Text] [PDF]

				D. H. Bhatt, S. J. Otto, B. Depoister, and J. R. Fetcho Cyclic AMP-Induced Repair of Zebrafish Spinal Circuits Science, July 9, 2004; 305(5681): 254 - 258. [Abstract] [Full Text] [PDF]

				S. J. Zottoli and M. M. Freemer Recovery of C-starts, equilibrium and targeted feeding after whole spinal cord crush in the adult goldfish Carassius auratus J. Exp. Biol., September 1, 2003; 206(17): 3015 - 3029. [Abstract] [Full Text] [PDF]

				T. OERTLE, M. KLINGER, C. A. O. STUERMER, and M. E. SCHWAB A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family FASEB J, July 1, 2003; 17(10): 1238 - 1247. [Abstract] [Full Text] [PDF]

				M.I. Shifman and M.E. Selzer Expression of the Netrin Receptor UNC-5 in Lamprey Brain: Modulation by Spinal Cord Transection Neurorehabil Neural Repair, January 1, 2000; 14(1): 49 - 58. [Abstract] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help