QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (22) Citing Articles via Google Scholar Google Scholar Articles by Grant, K. Articles by Bell, C. C. Search for Related Content PubMed PubMed Citation Articles by Grant, K. Articles by Bell, C. C.

 Previous Article  |  Next Article 

The Journal of Neuroscience, August 1, 1998, 18(15):6009-6025

The Mormyrid Electrosensory Lobe In Vitro: Physiology and Pharmacology of Cells and Circuits

Kirsty Grant¹, Yoshiko Sugawara², Leonel Gómez¹, Victor Z. Han³, and Curtis C. Bell³

¹ Institut Alfred Fessard, Centre National de la Recherche Scientifique, 91190 Gif sur Yvette, France, ² Department of Physiology, Teikyo University School of Medicine, Kaga 2-11-1, Itabashi-ku, Tokyo 173, Japan, and ³ Neurological Sciences Institute, Oregon Health Science University, Portland, Oregon 97209

This paper is concerned with the electrosensory lobe (ELL) of mormyrid electric fish as examined in in vitro slices. Intracellular recordings from morphologically identified cells and field potential recordings were used to characterize the physiology and pharmacology of ELL cells. Most intracellular recordings were from the Purkinje-like interneurons that are known as medium ganglion cells and from the two types of efferent neurons, large ganglion and large fusiform cells. Stimulation of primary afferent fibers elicits both excitatory and inhibitory effects in these cells, with the excitatory effects being mediated by both the AMPA and NMDA types of glutamate receptors and the inhibitory effects being mediated by both GABA_A and glycine receptors. Parallel-fiber stimulation evokes an EPSP-IPSP sequence, with the EPSPs being mediated by both AMPA and NMDA receptors and the IPSPs being mediated by GABA_A receptors only. The parallel fiber-evoked EPSPs and IPSPs show marked paired-pulse facilitation. A large and unusually broad spike is recorded inside medium ganglion cells, and field potential responses suggest that this spike is propagated into the apical dendrites. The results provide essential information for understanding how peripheral and central inputs are integrated in ELL.

Key words: mormyrid; electrosensory; electric fish; ELL; cerebellum; NMDA; AMPA; glycine; GABA; sensory processing

---

Copyright © 1998 Society for Neuroscience  0270-6474/98/18156009-17$05.00/0

This article has been cited by other articles:

				E. H. van den Burg, J. Engelmann, J. Bacelo, L. Gomez, and K. Grant Etomidate Reduces Initiation of Backpropagating Dendritic Action Potentials: Implications for Sensory Processing and Synaptic Plasticity During Anesthesia J Neurophysiol, March 1, 2007; 97(3): 2373 - 2384. [Abstract] [Full Text] [PDF]

				J. Zhang, V. Z. Han, J. Meek, and C. C. Bell Granular Cells of the Mormyrid Electrosensory Lobe and Postsynaptic Control Over Presynaptic Spike Occurrence and Amplitude Through an Electrical Synapse J Neurophysiol, March 1, 2007; 97(3): 2191 - 2203. [Abstract] [Full Text] [PDF]

				N. B. Sawtell, A. Williams, and C. C. Bell Central Control of Dendritic Spikes Shapes the Responses of Purkinje-Like Cells through Spike Timing-Dependent Synaptic Plasticity J. Neurosci., February 14, 2007; 27(7): 1552 - 1565. [Abstract] [Full Text] [PDF]

				L. Gomez, M. Kanneworff, R. Budelli, and K. Grant Dendritic spike back propagation in the electrosensory lobe of Gnathonemus petersii J. Exp. Biol., January 1, 2005; 208(1): 141 - 155. [Abstract] [Full Text] [PDF]

				V. Z. Han and C. C. Bell Physiology of Cells in the Central Lobes of the Mormyrid Cerebellum J. Neurosci., December 3, 2003; 23(35): 11147 - 11157. [Abstract] [Full Text] [PDF]

				C. Mohr, P. D. Roberts, and C. C. Bell The Mormyromast Region of the Mormyrid Electrosensory Lobe. I. Responses to Corollary Discharge and Electrosensory Stimuli J Neurophysiol, August 1, 2003; 90(2): 1193 - 1210. [Abstract] [Full Text] [PDF]

				C. Mohr, P. D. Roberts, and C. C. Bell The Mormyromast Region of the Mormyrid Electrosensory Lobe. II. Responses to Input From Central Sources J Neurophysiol, August 1, 2003; 90(2): 1211 - 1223. [Abstract] [Full Text] [PDF]

				N. Berman, R. J. Dunn, and L. Maler Function of NMDA Receptors and Persistent Sodium Channels in a Feedback Pathway of the Electrosensory System J Neurophysiol, October 1, 2001; 86(4): 1612 - 1621. [Abstract] [Full Text] [PDF]

				P. D. Roberts Modeling Inhibitory Plasticity in the Electrosensory System of Mormyrid Electric Fish J Neurophysiol, October 1, 2000; 84(4): 2035 - 2047. [Abstract] [Full Text] [PDF]

				V. Z. Han, K. Grant, and C. C. Bell Rapid Activation of GABAergic Interneurons and Possible Calcium Independent GABA Release in the Mormyrid Electrosensory Lobe J Neurophysiol, March 1, 2000; 83(3): 1592 - 1604. [Abstract] [Full Text] [PDF]

				J Meek, K Grant, and C Bell Structural organization of the mormyrid electrosensory lateral line lobe J. Exp. Biol., January 5, 1999; 202(10): 1291 - 1300. [Abstract] [PDF]

				Y Sugawara, K Grant, V Han, and C. Bell Physiology of electrosensory lateral line lobe neurons in Gnathonemus petersii J. Exp. Biol., January 5, 1999; 202(10): 1301 - 1309. [Abstract] [PDF]

				C. Bell, V. Han, Y Sugawara, and K Grant Synaptic plasticity in the mormyrid electrosensory lobe J. Exp. Biol., January 5, 1999; 202(10): 1339 - 1347. [Abstract] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help