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The Journal of Neuroscience, August 15, 1998, 18(16):6071-6080

When Are Class I Metabotropic Glutamate Receptors Necessary for Long-Term Potentiation?

Volker W. Wilsch¹, Thomas Behnisch¹, Tino Jäger¹, Klaus G. Reymann^{1, 2}, and Detlef Balschun¹

¹ Leibniz Institute for Neurobiology, Department of Neurophysiology, and ² Research Institute of Applied Neurosciences gGmbH, D-39008 Magdeburg, Germany

The involvement of metabotropic glutamate receptors (mGluRs) in hippocampal long-term potentiation (LTP) is a matter of controversial debate. Using [Ca²⁺]_i measurements by confocal laser scanning microscopy and field recordings of EPSPs (fEPSPs) in the hippocampal CA1-region, we found that the efficacy of the broad-spectrum mGluR-antagonist (S)--methyl-4-carboxyphenylglycine (MCPG) and of (S)-4-carboxy-phenylglycine (4-CPG), a selective antagonist at class I mGluRs, in LTP is contingent on the tetanization strength and the resulting [Ca²⁺]_i response. As indicated by experiments in which we blocked voltage-dependent calcium channels (VDCCs) and intracellular Ca²⁺ stores (ICSs), the functional significance of class I mGluRs in LTP is confined to certain types of potentiation, which are induced by weak tetanization protocols and require the release of Ca²⁺ from ICSs for induction. During strong tetanic stimulation, this Ca²⁺ source is functionally bypassed by activating VDCCs.

Key words: class I metabotropic glutamate receptors; long-term potentiation; intracellular calcium concentration; intracellular calcium stores; voltage-dependent calcium channels; hippocampus

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Copyright © 1998 Society for Neuroscience  0270-6474/98/18166071-10$05.00/0

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