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The Journal of Neuroscience, September 1, 1998, 18(17):6650-6661
Inwardly Rectifying Potassium (IRK) Currents Are Correlated with IRK Subunit Expression in Rat Nucleus Accumbens Medium Spiny Neurons
Paul G. Mermelstein, Wen-Jie Song, Tatiana Tkatch, Zhen Yan, and D. James Surmeier Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis Tennessee 38163
Inwardly rectifying K+ (IRK) channels are critical for shaping cell excitability. Whole-cell patch-clamp and single-cell RT-PCR techniques were used to characterize the inwardly rectifying K+ currents found in projection neurons of the rat nucleus accumbens. Inwardly rectifying currents were highly selective for K+ and blocked by low millimolar concentrations of Cs+ or Ba2+. In a subset of neurons, the inwardly rectifying current appeared to inactivate at hyperpolarized membrane potentials. In an attempt to identify this subset, neurons were profiled using single-cell RT-PCR. Neurons expressing substance P mRNA exhibited noninactivating inward rectifier currents, whereas neurons expressing enkephalin mRNA exhibited inactivating inward rectifier currents. The inactivation of the inward rectifier was correlated with the expression of IRK1 mRNA. These results demonstrate a clear physiological difference in the properties of medium spiny neurons and suggest that this difference could influence active state transitions driven by cortical and hippocampal excitatory input.
Key words: ventral striatum; medium spiny neurons; single-cell RT-PCR; voltage clamp; potassium channels; inward rectifier; enkephalin; substance P
Copyright © 1998 Society for Neuroscience 0270-6474/98/18176650-12$05.00/0
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