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The Journal of Neuroscience, September 1, 1998, 18(17):6776-6789
Spontaneous Activity of Solitary Dopaminergic Cells of the Retina
Andreas Feigenspan, Stefano Gustincich, Bruce P. Bean, and Elio Raviola Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115
Dopaminergic interplexiform amacrine cells were labeled in transgenic mice with human placental alkaline phosphatase and could therefore be identified after dissociation of the retina and used for whole-cell current and voltage clamp. In absence of synaptic inputs, dopaminergic amacrines spontaneously fired action potentials in a rhythmic pattern. This activity was remarkably robust in the face of inhibition of various voltage-dependent ion channels. It was minimally affected by external cesium or cobalt, suggesting no involvement of either the hyperpolarization-activated cation current Ih or voltage-dependent calcium channels. Inhibiting calcium-activated potassium channels by charybdotoxin or tetraethylammonium slowed the repolarizing phase of the action potentials and eliminated a slow afterhyperpolarization but had a scarce effect on the frequency of spontaneous firing. Voltage-clamp experiments showed that the interspike depolarization leading to threshold results from tetrodotoxin-sensitive sodium channels active at the interspike voltages of
60 to
Key words: dopamine; retina; interplexiform amacrine cells; patch clamp; pacemaker activity; ion channels; subthreshold sodium current
Copyright © 1998 Society for Neuroscience 0270-6474/98/18176776-14$05.00/0
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