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The Journal of Neuroscience, September 1, 1998, 18(17):6892-6904
N-Cadherin Redistribution during Synaptogenesis in Hippocampal Neurons
Deanna L. Benson1 and Hidekazu Tanaka2 1 Fishberg Research Center for Neurobiology and 2 Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029
Cadherins are homophilic adhesion molecules that, together with their intracellular binding partners the catenins, mediate adhesion and signaling at a variety of intercellular junctions. This study shows that neural (N)-cadherin and
-catenin, an intracellular binding partner for the classic cadherins, are present in axons and dendrites before synapse formation and then cluster at developing synapses between hippocampal neurons. N-cadherin is expressed initially at all synaptic sites but rapidly becomes restricted to a subpopulation of excitatory synaptic sites. Sites of GABAergic, inhibitory synapses in mature cultures therefore lack N-cadherin but are associated with clusters of
Key words: N-cadherin;
Copyright © 1998 Society for Neuroscience 0270-6474/98/18176892-13$05.00/0
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