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The Journal of Neuroscience, September 15, 1998, 18(18):7075-7083
Nicotinic Stimulation Produces Multiple Forms of Increased
Glutamatergic Synaptic Transmission
Kristofer A.
Radcliffe and
John A.
Dani
Division of Neuroscience, Baylor College of Medicine, Houston,
Texas 77030-3498
Synaptic modulation and long-term synaptic changes are thought to
be the cellular correlates for learning and memory (; ; ). The hippocampus is a
center for learning and memory that receives abundant cholinergic
innervation and has a high density of nicotinic acetylcholine receptors
(nAChRs) (; ). We report that strong, brief
stimulation of nAChRs enhanced hippocampal glutamatergic synaptic
transmission on two independent time scales and altered the
relationship between consecutively evoked synaptic currents. The
nicotinic synaptic enhancement required extracellular calcium and was
produced by the activation of presynaptic  7-containing nAChRs.
Although one form of glutamatergic enhancement lasted only for seconds,
another form lasted for minutes after the nicotinic stimulation had
ceased and the nicotinic agonist had been washed away. The synaptic
enhancement lasting minutes suggests that nAChR activity can initiate
calcium-dependent mechanisms that are known to induce glutamatergic
synaptic plasticity. The results with evoked synaptic currents showed
that nAChR activity can alter the relationship between the incoming
presynaptic activity and outgoing postsynaptic signaling along
glutamatergic fibers. Thus, the same information arriving along the
same glutamatergic afferents will be processed differently when
properly timed nicotinic activity converges onto the glutamatergic
presynaptic terminals. Influencing information processing at
glutamatergic synapses may be one way in which nicotinic cholinergic
activity influences cognitive processes. Disruption of these nicotinic
cholinergic mechanisms may contribute to the deficits associated with
the degeneration of cholinergic functions during Alzheimer's
disease.
Key words:
glutamate synaptic transmission; nicotinic acetylcholine
receptors; hippocampal cultures; synaptic modulation; learning; memory
Copyright © 1998 Society for Neuroscience 0270-6474/98/18187075-09$05.00/0
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