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The Journal of Neuroscience, September 15, 1998, 18(18):7118-7126
Postsynaptic Complex Spike Bursting Enables the Induction of LTP by Theta Frequency Synaptic Stimulation
Mark J. Thomas1, Ayako M. Watabe2, Teena D. Moody1, Michael Makhinson1, and Thomas J. O'Dell2 1 Interdepartmental PhD Program for Neuroscience and 2 Department of Physiology, School of Medicine, University of California, Los Angeles, Los Angeles, California 90095
Long-term potentiation (LTP), a persistent enhancement of synaptic transmission that may be involved in some forms of learning and memory, is induced at excitatory synapses in the CA1 region of the hippocampus by coincident presynaptic and postsynaptic activity. Although action potentials back-propagating into dendrites of hippocampal pyramidal cells provide sufficient postsynaptic activity to induce LTP under some in vitro conditions, it is not known whether LTP can be induced by patterns of postsynaptic action potential firing that occur in these cells in vivo. Here we report that a characteristic in vivo pattern of action potential generation in CA1 pyramidal cells known as the complex spike burst enables the induction of LTP during theta frequency synaptic stimulation in the CA1 region of hippocampal slices maintained in vitro. Our results suggest that complex spike bursting may have an important role in synaptic processes involved in learning and memory formation, perhaps by producing a highly sensitive postsynaptic state during which even low frequencies of presynaptic activity can induce LTP.
Key words: long-term potentiation; complex spike burst; hippocampus; pyramidal cells; synaptic transmission; learning and memory
Copyright © 1998 Society for Neuroscience 0270-6474/98/18187118-09$05.00/0
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