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The Journal of Neuroscience, October 1, 1998, 18(19):7613-7624
Dendritic Hyperpolarization-Activated Currents Modify the
Integrative Properties of Hippocampal CA1 Pyramidal Neurons
Jeffrey C.
Magee
Neuroscience Center, Louisiana State University Medical Center, New
Orleans, Louisiana 70112
Step hyperpolarizations evoked slowly activating, noninactivating,
and slowly deactivating inward currents from membrane patches recorded
in the cell-attached patch configuration from the soma and apical
dendrites of hippocampal CA1 pyramidal neurons. The density of these
hyperpolarization-activated currents
(Ih) increased over sixfold from soma
to distal dendrites. Activation curves demonstrate that a significant
fraction of Ih channels is active near rest
and that the range is hyperpolarized relatively more in the
distal dendrites. Ih activation and
deactivation kinetics are voltage-and temperature-dependent, with time
constants of activation and deactivation decreasing with
hyperpolarization and depolarization, respectively.
Ih demonstrated a mixed
Na+-K+ conductance and was
sensitive to low concentrations of external CsCl. Dual whole-cell
recordings revealed regional differences in input resistance
(Rin) and membrane polarization rates
( mem) across the somatodendritic axis that are
attributable to the spatial gradient of Ih
channels. As a result of these membrane effects the propagation of
subthreshold voltage transients is directionally specific. The elevated
dendritic Ih density decreases EPSP
amplitude and duration and reduces the time window over which temporal
summation takes place. The backpropagation of action potentials into
the dendritic arborization was impacted only slightly by dendritic Ih, with the most consistent effect
being a decrease in dendritic action potential duration and an increase
in afterhyperpolarization. Overall, Ih acts
to dampen dendritic excitability, but its largest impact is on the
subthreshold range of membrane potentials where the integration of
inhibitory and excitatory synaptic inputs takes place.
Key words:
hyperpolarization-activated current; dendrite; hippocampus; synaptic integration; CA1 pyramidal neuron; action
potential backpropagation
Copyright © 1998 Society for Neuroscience 0270-6474/98/18197613-12$05.00/0
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