 |
Next Article 
The Journal of Neuroscience, October 1, 1998, 18(19):7613-7624
Dendritic Hyperpolarization-Activated Currents Modify the
Integrative Properties of Hippocampal CA1 Pyramidal Neurons
Jeffrey C.
Magee
Neuroscience Center, Louisiana State University Medical Center, New
Orleans, Louisiana 70112
Step hyperpolarizations evoked slowly activating, noninactivating,
and slowly deactivating inward currents from membrane patches recorded
in the cell-attached patch configuration from the soma and apical
dendrites of hippocampal CA1 pyramidal neurons. The density of these
hyperpolarization-activated currents
(Ih) increased over sixfold from soma
to distal dendrites. Activation curves demonstrate that a significant
fraction of Ih channels is active near rest
and that the range is hyperpolarized relatively more in the
distal dendrites. Ih activation and
deactivation kinetics are voltage-and temperature-dependent, with time
constants of activation and deactivation decreasing with
hyperpolarization and depolarization, respectively.
Ih demonstrated a mixed
Na+-K+ conductance and was
sensitive to low concentrations of external CsCl. Dual whole-cell
recordings revealed regional differences in input resistance
(Rin) and membrane polarization rates
( mem) across the somatodendritic axis that are
attributable to the spatial gradient of Ih
channels. As a result of these membrane effects the propagation of
subthreshold voltage transients is directionally specific. The elevated
dendritic Ih density decreases EPSP
amplitude and duration and reduces the time window over which temporal
summation takes place. The backpropagation of action potentials into
the dendritic arborization was impacted only slightly by dendritic Ih, with the most consistent effect
being a decrease in dendritic action potential duration and an increase
in afterhyperpolarization. Overall, Ih acts
to dampen dendritic excitability, but its largest impact is on the
subthreshold range of membrane potentials where the integration of
inhibitory and excitatory synaptic inputs takes place.
Key words:
hyperpolarization-activated current; dendrite; hippocampus; synaptic integration; CA1 pyramidal neuron; action
potential backpropagation
Copyright © 1998 Society for Neuroscience 0270-6474/98/18197613-12$05.00/0
This article has been cited by other articles:
|
|
|
|
 
V. Volman, H. Levine, E. Ben-Jacob, and T. J. Sejnowski
Locally Balanced Dendritic Integration by Short-Term Synaptic Plasticity and Active Dendritic Conductances
J Neurophysiol,
December 1, 2009;
102(6):
3234 - 3250.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Gold, C. C. Girardin, K. A. C. Martin, and C. Koch
High-Amplitude Positive Spikes Recorded Extracellularly in Cat Visual Cortex
J Neurophysiol,
December 1, 2009;
102(6):
3340 - 3351.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Hu, K. Vervaeke, L. J. Graham, and J. F. Storm
Complementary Theta Resonance Filtering by Two Spatially Segregated Mechanisms in CA1 Hippocampal Pyramidal Neurons
J. Neurosci.,
November 18, 2009;
29(46):
14472 - 14483.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Li, F. Chen, J. Ye, X. Chen, J. Yan, Y. Li, Y. Xiong, Z. Zhou, J. Xia, and Z. Hu
The Modulation of Orexin A on HCN Currents of Pyramidal Neurons in Mouse Prelimbic Cortex
Cereb Cortex,
November 13, 2009;
(2009)
bhp241v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Zhang, Y. Liu, J. Qu, A. Hardy, N. Zhang, J. Diao, P. J Strijbos, R. Tsushima, R. B Robinson, H. Y Gaisano, et al.
Functional characterization of hyperpolarization-activated cyclic nucleotide-gated channels in rat pancreatic {beta} cells
J. Endocrinol.,
October 1, 2009;
203(1):
45 - 53.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. N. Routh, D. Johnston, K. Harris, and R. A. Chitwood
Anatomical and Electrophysiological Comparison of CA1 Pyramidal Neurons of the Rat and Mouse
J Neurophysiol,
October 1, 2009;
102(4):
2288 - 2302.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Polsky, B. Mel, and J. Schiller
Encoding and Decoding Bursts by NMDA Spikes in Basal Dendrites of Layer 5 Pyramidal Neurons
J. Neurosci.,
September 23, 2009;
29(38):
11891 - 11903.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Huang, M. C. Walker, and M. M. Shah
Loss of Dendritic HCN1 Subunits Enhances Cortical Excitability and Epileptogenesis
J. Neurosci.,
September 2, 2009;
29(35):
10979 - 10988.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. Atkinson and S. R. Williams
Postnatal Development of Dendritic Synaptic Integration in Rat Neocortical Pyramidal Neurons
J Neurophysiol,
August 1, 2009;
102(2):
735 - 751.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Biel, C. Wahl-Schott, S. Michalakis, and X. Zong
Hyperpolarization-Activated Cation Channels: From Genes to Function
Physiol Rev,
July 1, 2009;
89(3):
847 - 885.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Lewis, E. Schwartz, C. Savio Chan, Y. Noam, M. Shin, W. J. Wadman, D. James Surmeier, T. Z. Baram, R. L. Macdonald, and D. M. Chetkovich
Alternatively Spliced Isoforms of TRIP8b Differentially Control h Channel Trafficking and Function
J. Neurosci.,
May 13, 2009;
29(19):
6250 - 6265.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J. Barrow and S. M. Wu
Low-Conductance HCN1 Ion Channels Augment the Frequency Response of Rod and Cone Photoreceptors
J. Neurosci.,
May 6, 2009;
29(18):
5841 - 5853.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Huggenberger, M. Vater, and R. A. Deisz
Interlaminar Differences of Intrinsic Properties of Pyramidal Neurons in the Auditory Cortex of Mice
Cereb Cortex,
May 1, 2009;
19(5):
1008 - 1018.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Orio, R. Madrid, E. de la Peña, A.és Parra, Víc. Meseguer, D. A. Bayliss, C. Belmonte, and Fél. Viana
Characteristics and physiological role of hyperpolarization activated currents in mouse cold thermoreceptors
J. Physiol.,
May 1, 2009;
587(9):
1961 - 1976.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Li, S. S. Nair, and G. J. Quirk
A Biologically Realistic Network Model of Acquisition and Extinction of Conditioned Fear Associations in Lateral Amygdala Neurons
J Neurophysiol,
March 1, 2009;
101(3):
1629 - 1646.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Yan, Q. Li, R. Fleming, R. D. Madison, W. A. Wilson, and H. S. Swartzwelder
Developmental Sensitivity of Hippocampal Interneurons to Ethanol: Involvement of the Hyperpolarization-Activated Current, Ih
J Neurophysiol,
January 1, 2009;
101(1):
67 - 83.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Liu and M. T. Shipley
Intrinsic Conductances Actively Shape Excitatory and Inhibitory Postsynaptic Responses in Olfactory Bulb External Tufted Cells
J. Neurosci.,
October 8, 2008;
28(41):
10311 - 10322.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M. Giocomo and M. E. Hasselmo
Time Constants of h Current in Layer II Stellate Cells Differ along the Dorsal to Ventral Axis of Medial Entorhinal Cortex
J. Neurosci.,
September 17, 2008;
28(38):
9414 - 9425.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Campanac, G. Daoudal, N. Ankri, and D. Debanne
Downregulation of Dendritic Ih in CA1 Pyramidal Neurons after LTP
J. Neurosci.,
August 20, 2008;
28(34):
8635 - 8643.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. K. Andrasfalvy, J. K. Makara, D. Johnston, and J. C. Magee
Altered synaptic and non-synaptic properties of CA1 pyramidal neurons in Kv4.2 knockout mice
J. Physiol.,
August 15, 2008;
586(16):
3881 - 3892.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Krause, Z. Yang, G. Rao, F. P. Houston, and C. A. Barnes
Altered Dendritic Integration in Hippocampal Granule Cells of Spatial Learning-Impaired Aged Rats
J Neurophysiol,
June 1, 2008;
99(6):
2769 - 2778.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Calixto, E. J. Galvan, J. P. Card, and G. Barrionuevo
Coincidence detection of convergent perforant path and mossy fibre inputs by CA3 interneurons
J. Physiol.,
June 1, 2008;
586(11):
2695 - 2712.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Narayanan and D. Johnston
The h Channel Mediates Location Dependence and Plasticity of Intrinsic Phase Response in Rat Hippocampal Neurons
J. Neurosci.,
May 28, 2008;
28(22):
5846 - 5860.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Endo, E. Tarusawa, T. Notomi, K. Kaneda, M. Hirabayashi, R. Shigemoto, and T. Isa
Dendritic Ih Ensures High-Fidelity Dendritic Spike Responses of Motion-Sensitive Neurons in Rat Superior Colliculus
J Neurophysiol,
May 1, 2008;
99(5):
2066 - 2076.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Wanat, F. W. Hopf, G. D. Stuber, P. E. M. Phillips, and A. Bonci
Corticotropin-releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C-dependent enhancement of Ih
J. Physiol.,
April 15, 2008;
586(8):
2157 - 2170.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser
Dendritic Excitability and Synaptic Plasticity
Physiol Rev,
April 1, 2008;
88(2):
769 - 840.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Campanac and D. Debanne
Spike timing-dependent plasticity: a learning rule for dendritic integration in rat CA1 pyramidal neurons
J. Physiol.,
February 1, 2008;
586(3):
779 - 793.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. H. Brager and D. Johnston
Plasticity of Intrinsic Excitability during Long-Term Depression Is Mediated through mGluR-Dependent Changes in Ih in Hippocampal CA1 Pyramidal Neurons
J. Neurosci.,
December 19, 2007;
27(51):
13926 - 13937.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Jung, T. D. Jones, J. N. Lugo Jr, A. H. Sheerin, J. W. Miller, R. D'Ambrosio, A. E. Anderson, and N. P. Poolos
Progressive Dendritic HCN Channelopathy during Epileptogenesis in the Rat Pilocarpine Model of Epilepsy
J. Neurosci.,
November 21, 2007;
27(47):
13012 - 13021.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. F. Nolan, J. T. Dudman, P. D. Dodson, and B. Santoro
HCN1 Channels Control Resting and Active Integrative Properties of Stellate Cells from Layer II of the Entorhinal Cortex
J. Neurosci.,
November 14, 2007;
27(46):
12440 - 12451.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Shin and D. M. Chetkovich
Activity-dependent Regulation of h Channel Distribution in Hippocampal CA1 Pyramidal Neurons
J. Biol. Chem.,
November 9, 2007;
282(45):
33168 - 33180.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. P. Cook, J. A. Guest, Y. Liang, N. Y. Masse, and C. M. Colbert
Dendrite-to-Soma Input/Output Function of Continuous Time-Varying Signals in Hippocampal CA1 Pyramidal Neurons
J Neurophysiol,
November 1, 2007;
98(5):
2943 - 2955.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. B. Carr, G. D. Andrews, W. B. Glen, and A. Lavin
{alpha}2-Noradrenergic receptors activation enhances excitability and synaptic integration in rat prefrontal cortex pyramidal neurons via inhibition of HCN currents
J. Physiol.,
October 15, 2007;
584(2):
437 - 450.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Angelo, M. London, S. R. Christensen, and M. Hausser
Local and Global Effects of Ih Distribution in Dendrites of Mammalian Neurons
J. Neurosci.,
August 8, 2007;
27(32):
8643 - 8653.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-W. Ying, F. Jia, S. Y. Abbas, F. Hofmann, A. Ludwig, and P. A. Goldstein
Dendritic HCN2 Channels Constrain Glutamate-Driven Excitability in Reticular Thalamic Neurons
J. Neurosci.,
August 8, 2007;
27(32):
8719 - 8732.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. C. Rotaru, D. A. Lewis, and G. Gonzalez-Burgos
Dopamine D1 receptor activation regulates sodium channel-dependent EPSP amplification in rat prefrontal cortex pyramidal neurons
J. Physiol.,
June 15, 2007;
581(3):
981 - 1000.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. E. Gipson and M. F. Yeckel
Coincident Glutamatergic and Cholinergic Inputs Transiently Depress Glutamate Release at Rat Schaffer Collateral Synapses
J Neurophysiol,
June 1, 2007;
97(6):
4108 - 4119.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Fernandez de Sevilla, M. Fuenzalida, A. B. Porto Pazos, and W. Buno
Selective Shunting of the NMDA EPSP Component by the Slow Afterhyperpolarization in Rat CA1 Pyramidal Neurons
J Neurophysiol,
May 1, 2007;
97(5):
3242 - 3255.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Gasparini, A. Losonczy, X. Chen, D. Johnston, and J. C. Magee
Associative pairing enhances action potential back-propagation in radial oblique branches of CA1 pyramidal neurons
J. Physiol.,
May 1, 2007;
580(3):
787 - 800.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Bender, T. Kirschstein, O. Kretz, A. L. Brewster, C. Richichi, C. Ruschenschmidt, R. Shigemoto, H. Beck, M. Frotscher, and T. Z. Baram
Localization of HCN1 Channels to Presynaptic Compartments: Novel Plasticity That May Contribute to Hippocampal Maturation
J. Neurosci.,
April 25, 2007;
27(17):
4697 - 4706.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. L. Brewster, Y. Chen, R. A. Bender, A. Yeh, R. Shigemoto, and T. Z. Baram
Quantitative Analysis and Subcellular Distribution of mRNA and Protein Expression of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels throughout Development in Rat Hippocampus
Cereb Cortex,
March 1, 2007;
17(3):
702 - 712.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. B. Bullis, T. D. Jones, and N. P. Poolos
Reversed somatodendritic Ih gradient in a class of rat hippocampal neurons with pyramidal morphology
J. Physiol.,
March 1, 2007;
579(2):
431 - 443.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. Colbert
A circuit within a circuit?
J. Physiol.,
March 1, 2007;
579(2):
289 - 289.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Hu, K. Vervaeke, and J. F. Storm
M-Channels (Kv7/KCNQ Channels) That Regulate Synaptic Integration, Excitability, and Spike Pattern of CA1 Pyramidal Cells Are Located in the Perisomatic Region
J. Neurosci.,
February 21, 2007;
27(8):
1853 - 1867.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Puopolo, E. Raviola, and B. P. Bean
Roles of Subthreshold Calcium Current and Sodium Current in Spontaneous Firing of Mouse Midbrain Dopamine Neurons
J. Neurosci.,
January 17, 2007;
27(3):
645 - 656.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Bruening-Wright and H. P. Larsson
Slow Conformational Changes of the Voltage Sensor during the Mode Shift in Hyperpolarization-Activated Cyclic-Nucleotide-Gated Channels
J. Neurosci.,
January 10, 2007;
27(2):
270 - 278.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Gabbiani and H. G. Krapp
Spike-Frequency Adaptation and Intrinsic Properties of an Identified, Looming-Sensitive Neuron
J Neurophysiol,
December 1, 2006;
96(6):
2951 - 2962.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Orban, T. Kiss, and P. Erdi
Intrinsic and Synaptic Mechanisms Determining the Timing of Neuron Population Activity During Hippocampal Theta Oscillation
J Neurophysiol,
December 1, 2006;
96(6):
2889 - 2904.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. Peck, E. Gaier, E. Stevens, S. Repicky, and R. M. Harris-Warrick
Amine Modulation of Ih in a Small Neural Network
J Neurophysiol,
December 1, 2006;
96(6):
2931 - 2940.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Lawrence, F. Saraga, J. F. Churchill, J. M. Statland, K. E. Travis, F. K. Skinner, and C. J. McBain
Somatodendritic Kv7/KCNQ/M Channels Control Interspike Interval in Hippocampal Interneurons.
J. Neurosci.,
November 22, 2006;
26(47):
12325 - 12338.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Wang, S. Haj-Dahmane, and R.-Y. Shen
Effects of Prenatal Ethanol Exposure on the Excitability of Ventral Tegmental Area Dopamine Neurons in Vitro
J. Pharmacol. Exp. Ther.,
November 1, 2006;
319(2):
857 - 863.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Y. Chang and M. B. Jackson
Heterogeneous spatial patterns of long-term potentiation in rat hippocampal slices
J. Physiol.,
October 15, 2006;
576(2):
427 - 443.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Golomb, C. Yue, and Y. Yaari
Contribution of Persistent Na+ Current and M-Type K+ Current to Somatic Bursting in CA1 Pyramidal Cells: Combined Experimental and Modeling Study
J Neurophysiol,
October 1, 2006;
96(4):
1912 - 1926.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. van Welie, M. W. H. Remme, J. A. van Hooft, and W. J. Wadman
Different levels of Ih determine distinct temporal integration in bursting and regular-spiking neurons in rat subiculum
J. Physiol.,
October 1, 2006;
576(1):
203 - 214.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. R. Holmes and L. M. Grover
Quantifying the Magnitude of Changes in Synaptic Level Parameters With Long-Term Potentiation
J Neurophysiol,
September 1, 2006;
96(3):
1478 - 1491.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Simon
Ion channel proteins in neuronal temperature transduction: from inferences to testable theories of deep-body thermosensitivity
Am J Physiol Regulatory Integrative Comp Physiol,
September 1, 2006;
291(3):
R515 - R517.
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Elinder, R. Mannikko, S. Pandey, and H. P. Larsson
Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels
J. Physiol.,
September 1, 2006;
575(2):
417 - 431.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. B. Hardie and R. A. Pearce
Active and Passive Membrane Properties and Intrinsic Kinetics Shape Synaptic Inhibition in Hippocampal CA1 Pyramidal Neurons.
J. Neurosci.,
August 15, 2006;
26(33):
8559 - 8569.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. J. M. Huys, M. B. Ahrens, and L. Paninski
Efficient Estimation of Detailed Single-Neuron Models
J Neurophysiol,
August 1, 2006;
96(2):
872 - 890.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. L. Taylor, T. J. Hickey, A. A. Prinz, and E. Marder
Structure and Visualization of High-Dimensional Conductance Spaces
J Neurophysiol,
August 1, 2006;
96(2):
891 - 905.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. P. Poolos, J. B. Bullis, and M. K. Roth
Modulation of h-channels in hippocampal pyramidal neurons by p38 mitogen-activated protein kinase.
J. Neurosci.,
July 26, 2006;
26(30):
7995 - 8003.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Gibson, A. F. Bartley, and K. M. Huber
Role for the Subthreshold Currents ILeak and IH in the Homeostatic Control of Excitability in Neocortical Somatostatin-Positive Inhibitory Neurons
J Neurophysiol,
July 1, 2006;
96(1):
420 - 432.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Dan and M.-M. Poo
Spike timing-dependent plasticity: from synapse to perception.
Physiol Rev,
July 1, 2006;
86(3):
1033 - 1048.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Yue and Y. Yaari
Axo-Somatic and Apical Dendritic Kv7/M Channels Differentially Regulate the Intrinsic Excitability of Adult Rat CA1 Pyramidal Cells
J Neurophysiol,
June 1, 2006;
95(6):
3480 - 3495.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Rateau and N. Ropert
Expression of a Functional Hyperpolarization-Activated Current (Ih) in the Mouse Nucleus Reticularis Thalami
J Neurophysiol,
May 1, 2006;
95(5):
3073 - 3085.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Gold, D. A. Henze, C. Koch, and G. Buzsaki
On the Origin of the Extracellular Action Potential Waveform: A Modeling Study
J Neurophysiol,
May 1, 2006;
95(5):
3113 - 3128.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Rosenkranz and D. Johnston
Dopaminergic regulation of neuronal excitability through modulation of Ih in layer V entorhinal cortex.
J. Neurosci.,
March 22, 2006;
26(12):
3229 - 3244.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N.-l. Xu, C.-q. Ye, M.-m. Poo, and X.-h. Zhang
Coincidence detection of synaptic inputs is facilitated at the distal dendrites after long-term potentiation induction.
J. Neurosci.,
March 15, 2006;
26(11):
3002 - 3009.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Gasparini and J. C. Magee
State-Dependent Dendritic Computation in Hippocampal CA1 Pyramidal Neurons
J. Neurosci.,
February 15, 2006;
26(7):
2088 - 2100.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. H. P. Kole, S. Hallermann, and G. J. Stuart
Single Ih Channels in Pyramidal Neuron Dendrites: Properties, Distribution, and Impact on Action Potential Output
J. Neurosci.,
February 8, 2006;
26(6):
1677 - 1687.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. R. Lupica and M. S. Brodie
Queer Currents, Steady Rhythms, and Drunken DA Neurons. Focus on "Hyperpolarization-Activated Cation Current (Ih) Is an Ethanol Target in Midbrain Dopamine Neurons of Mice"
J Neurophysiol,
February 1, 2006;
95(2):
585 - 586.
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Okamoto, M. T. Harnett, and H. Morikawa
Hyperpolarization-Activated Cation Current (Ih) Is an Ethanol Target in Midbrain Dopamine Neurons of Mice
J Neurophysiol,
February 1, 2006;
95(2):
619 - 626.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. McDermott, M. N. Hardy, N. G. Bazan, and J. C. Magee
Sleep deprivation-induced alterations in excitatory synaptic transmission in the CA1 region of the rat hippocampus
J. Physiol.,
February 1, 2006;
570(3):
553 - 565.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. R. Anderson, B. Hu, K. Iremonger, and Z. H. T. Kiss
Selective Attenuation of Afferent Synaptic Transmission as a Mechanism of Thalamic Deep Brain Stimulation-Induced Tremor Arrest
J. Neurosci.,
January 18, 2006;
26(3):
841 - 850.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. A. Rodrigues and D. Oertel
Hyperpolarization-Activated Currents Regulate Excitability in Stellate Cells of the Mammalian Ventral Cochlear Nucleus
J Neurophysiol,
January 1, 2006;
95(1):
76 - 87.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Migliore, M. Ferrante, and G. A. Ascoli
Signal Propagation in Oblique Dendrites of CA1 Pyramidal Cells
J Neurophysiol,
December 1, 2005;
94(6):
4145 - 4155.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. A Simeone, J. M Rho, and T. Z Baram
Single channel properties of hyperpolarization-activated cation currents in acutely dissociated rat hippocampal neurones
J. Physiol.,
October 15, 2005;
568(2):
371 - 380.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. L Golding, T. J Mickus, Y. Katz, W. L Kath, and N. Spruston
Factors mediating powerful voltage attenuation along CA1 pyramidal neuron dendrites
J. Physiol.,
October 1, 2005;
568(1):
69 - 82.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Yamada, H. Kuba, T. M. Ishii, and H. Ohmori
Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channels Regulate Auditory Coincidence Detection in Nucleus Laminaris of the Chick
J. Neurosci.,
September 28, 2005;
25(39):
8867 - 8877.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Day, D. B. Carr, S. Ulrich, E. Ilijic, T. Tkatch, and D. J. Surmeier
Dendritic Excitability of Mouse Frontal Cortex Pyramidal Neurons Is Shaped by the Interaction among HCN, Kir2, and Kleak Channels
J. Neurosci.,
September 21, 2005;
25(38):
8776 - 8787.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Gu, K. Vervaeke, H. Hu, and J. F Storm
Kv7/KCNQ/M and HCN/h, but not KCa2/SK channels, contribute to the somatic medium after-hyperpolarization and excitability control in CA1 hippocampal pyramidal cells
J. Physiol.,
August 1, 2005;
566(3):
689 - 715.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Wu and J. J. Hablitz
Cooperative Activation of D1 and D2 Dopamine Receptors Enhances a Hyperpolarization-Activated Inward Current in Layer I Interneurons
J. Neurosci.,
July 6, 2005;
25(27):
6322 - 6328.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-J. Cao and D. Oertel
Temperature Affects Voltage-Sensitive Conductances Differentially in Octopus Cells of the Mammalian Cochlear Nucleus
J Neurophysiol,
July 1, 2005;
94(1):
821 - 832.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Yasui, S. Fujisawa, M. Tsukamoto, N. Matsuki, and Y. Ikegaya
Dynamic synapses as archives of synaptic history: state-dependent redistribution of synaptic efficacy in the rat hippocampal CA1
J. Physiol.,
July 1, 2005;
566(1):
143 - 160.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Swensen and B. P. Bean
Robustness of Burst Firing in Dissociated Purkinje Neurons with Acute or Long-Term Reductions in Sodium Conductance
J. Neurosci.,
April 6, 2005;
25(14):
3509 - 3520.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-W. Ying and P. A. Goldstein
Propofol-Block of SK Channels in Reticular Thalamic Neurons Enhances GABAergic Inhibition in Relay Neurons
J Neurophysiol,
April 1, 2005;
93(4):
1935 - 1948.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ariel and N. Kogo
Shunting Inhibition in Accessory Optic System Neurons
J Neurophysiol,
April 1, 2005;
93(4):
1959 - 1969.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Chen and N. G. Bazan
Endogenous PGE2 Regulates Membrane Excitability and Synaptic Transmission in Hippocampal CA1 Pyramidal Neurons
J Neurophysiol,
February 1, 2005;
93(2):
929 - 941.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Gasparini, M. Migliore, and J. C. Magee
On the Initiation and Propagation of Dendritic Spikes in CA1 Pyramidal Neurons
J. Neurosci.,
December 8, 2004;
24(49):
11046 - 11056.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Toledo-Rodriguez, B. Blumenfeld, C. Wu, J. Luo, B. Attali, P. Goodman, and H. Markram
Correlation Maps Allow Neuronal Electrical Properties to be Predicted from Single-cell Gene Expression Profiles in Rat Neocortex
Cereb Cortex,
December 1, 2004;
14(12):
1310 - 1327.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Santoro, B. J. Wainger, and S. A. Siegelbaum
Regulation of HCN Channel Surface Expression by a Novel C-Terminal Protein-Protein Interaction
J. Neurosci.,
November 24, 2004;
24(47):
10750 - 10762.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. Chan, R. Shigemoto, J. N. Mercer, and D. J. Surmeier
HCN2 and HCN1 Channels Govern the Regularity of Autonomous Pacemaking and Synaptic Resetting in Globus Pallidus Neurons
J. Neurosci.,
November 3, 2004;
24(44):
9921 - 9932.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Gravante, A. Barbuti, R. Milanesi, I. Zappi, C. Viscomi, and D. DiFrancesco
Interaction of the Pacemaker Channel HCN1 with Filamin A
J. Biol. Chem.,
October 15, 2004;
279(42):
43847 - 43853.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. A. Otmakhova and J. E. Lisman
Contribution of Ih and GABAB to Synaptically Induced Afterhyperpolarizations in CA1: A Brake on the NMDA Response
J Neurophysiol,
October 1, 2004;
92(4):
2027 - 2039.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. W. Wu, C. S. Chan, and J. F. Disterhoft
Slow Afterhyperpolarization Governs the Development of NMDA Receptor-Dependent Afterdepolarization in CA1 Pyramidal Neurons During Synaptic Stimulation
J Neurophysiol,
October 1, 2004;
92(4):
2346 - 2356.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. K. Andrasfalvy and J. C. Magee
Changes in AMPA receptor currents following LTP induction on rat CA1 pyramidal neurones
J. Physiol.,
September 1, 2004;
559(2):
543 - 554.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Chen and D. Johnston
Properties of single voltage-dependent K+ channels in dendrites of CA1 pyramidal neurones of rat hippocampus
J. Physiol.,
August 15, 2004;
559(1):
187 - 203.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Bernard, A. Anderson, A. Becker, N. P. Poolos, H. Beck, and D. Johnston
Acquired Dendritic Channelopathy in Temporal Lobe Epilepsy
Science,
July 23, 2004;
305(5683):
532 - 535.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kimura, J. Kitano, Y. Nakajima, and S. Nakanishi
Hyperpolarization-activated, cyclic nucleotide-gated HCN2 cation channel forms a protein assembly with multiple neuronal scaffold proteins in distinct modes of protein-protein interaction
Genes Cells,
July 1, 2004;
9(7):
631 - 640.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
