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The Journal of Neuroscience, October 1, 1998, 18(19):7800-7810

Requirement for Early-Generated Neurons Recognized by Monoclonal Antibody Lot1 in the Formation of Lateral Olfactory Tract

Yasufumi Sato1, Tatsumi Hirata1, Masaharu Ogawa2, and Hajime Fujisawa1

1 Division of Biological Science, Nagoya University Graduate School of Science, Chikusa-ku, Nagoya 464-8602, Japan, and 2 Department of Physiology, Kochi Medical School, Kochi 783-8505, Japan

During development, mitral cells, the main output neurons of the olfactory bulb, project axons into a very narrow part of the telencephalon and form an axonal bundle called the lateral olfactory tract (LOT). The present study shows that before the first mitral cell axons elongate, the LOT position is already marked with a subset of early-generated neurons that are recognized by monoclonal antibody lot1 (lot cells). Mitral cell axons choose the lot cell position for their growth pathway and maintain a close contact with the cells until LOT formation is completed. Ablation of lot cells prevented LOT formation in organotypic culture. These results suggest that lot cells are "guidepost cells" for mitral cell axons.

Key words: lot cell; lateral olfactory tract; mitral cell; monoclonal antibody; guidepost; Cajal-Retzius cell; development

Copyright © 1998 Society for Neuroscience  0270-6474/98/18197800-11$05.00/0


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