QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (41) Citing Articles via Google Scholar Google Scholar Articles by Hoang, B. Articles by Chiba, A. Search for Related Content PubMed PubMed Citation Articles by Hoang, B. Articles by Chiba, A.

 Previous Article  |  Next Article 

The Journal of Neuroscience, October 1, 1998, 18(19):7847-7855

Genetic Analysis on the Role of Integrin during Axon Guidance in Drosophila

Bao Hoang and Akira Chiba

Department of Cell and Structural Biology, University of Illinois, Urbana, Illinois 61801

Heterodimeric cell surface receptor integrin is widely expressed in the nervous system, but its specific role during axon development has not been directly tested in vivo. We show that the Drosophila nervous system expresses low levels of positron-specific (PS) integrin subunits PS1, PS2, and PS during embryonic axogenesis. Furthermore, certain subsets of neurons express higher levels of integrin mRNAs than do the rest. Null mutations in either the PS1 or PS2 subunit gene cause widespread axon pathfinding errors that can be rescued by supplying the wild-type integrin subunit to the mutant nervous system. In contrast, misexpressing either the PS1 or PS2 integrin subunit in all neurons leads to no obvious axon pathfinding errors. We propose that integrin does not itself serve as either a "clutch" constituting molecule or a specific growth cone "receptor," as proposed previously, but rather as part of a molecular network that cooperatively guarantees accurate axon guidance.

Key words: PS1; PS2; axon guidance; PS; Drosophila; growth cone; inflated; integrin; multiple edematous wings; myospheroid; neuromuscular; pathfinding

---

Copyright © 1998 Society for Neuroscience  0270-6474/98/18197847-09$05.00/0

This article has been cited by other articles:

				B. S. Abrahams, D. Tentler, J. V. Perederiy, M. C. Oldham, G. Coppola, and D. H. Geschwind Genome-wide analyses of human perisylvian cerebral cortical patterning PNAS, November 6, 2007; 104(45): 17849 - 17854. [Abstract] [Full Text] [PDF]

				Z. Huang, U. Yazdani, K. L. Thompson-Peer, A. L. Kolodkin, and J. R. Terman Crk-associated substrate (Cas) signaling protein functions with integrins to specify axon guidance during development Development, June 15, 2007; 134(12): 2337 - 2347. [Abstract] [Full Text] [PDF]

				H. Buff, A. C. Smith, and C. A. Korey Genetic Modifiers of Drosophila Palmitoyl-Protein Thioesterase 1-Induced Degeneration Genetics, May 1, 2007; 176(1): 209 - 220. [Abstract] [Full Text] [PDF]

				Z. Huang, K. Shimazu, N. H. Woo, K. Zang, U. Muller, B. Lu, and L. F. Reichardt Distinct Roles of the beta1-Class Integrins at the Developing and the Mature Hippocampal Excitatory Synapse J. Neurosci., October 25, 2006; 26(43): 11208 - 11219. [Abstract] [Full Text] [PDF]

				P. Bhandari, J. W. Gargano, M. M. Goddeeris, and M. S. Grotewiel Behavioral Responses to Odorants in Drosophila Require Nervous System Expression of the {beta} Integrin Gene Myospheroid Chem Senses, September 1, 2006; 31(7): 627 - 639. [Abstract] [Full Text] [PDF]

				J. K. Inlow and L. L. Restifo Molecular and Comparative Genetics of Mental Retardation Genetics, February 1, 2004; 166(2): 835 - 881. [Abstract] [Full Text] [PDF]

				K. Beumer, H. J. G. Matthies, A. Bradshaw, and K. Broadie Integrins regulate DLG/FAS2 via a CaM kinase II-dependent pathway to mediate synapse elaboration and stabilization during postembryonic development Development, March 9, 2003; 129(14): 3381 - 3391. [Abstract] [Full Text] [PDF]

				A. Stevens and J. R. Jacobs Integrins Regulate Responsiveness to Slit Repellent Signals J. Neurosci., June 1, 2002; 22(11): 4448 - 4455. [Abstract] [Full Text] [PDF]

				C. A. Korey, G. Wilkie, I. Davis, and D. Van Vactor small bristles Is Required for the Morphogenesis of Multiple Tissues During Drosophila Development Genetics, December 1, 2001; 159(4): 1659 - 1670. [Abstract] [Full Text] [PDF]

				S. Lee, K.-L. Harris, P. M. Whitington, and P. A. Kolodziej short stop Is Allelic to kakapo, and Encodes Rod-Like Cytoskeletal-Associated Proteins Required for Axon Extension J. Neurosci., February 1, 2000; 20(3): 1096 - 1108. [Abstract] [Full Text] [PDF]

				J. Fujimoto, K. Sawamoto, M. Okabe, Y. Takagi, T. Tezuka, S. Yoshikawa, H. Ryo, H. Okano, and T. Yamamoto Cloning and Characterization of Dfak56, a Homolog of Focal Adhesion Kinase, in Drosophila melanogaster J. Biol. Chem., October 8, 1999; 274(41): 29196 - 29201. [Abstract] [Full Text] [PDF]

				B. Sun, P. Xu, and P. M. Salvaterra Dynamic visualization of nervous system in live Drosophila PNAS, August 31, 1999; 96(18): 10438 - 10443. [Abstract] [Full Text] [PDF]

				K. Beumer, J Rohrbough, A Prokop, and K Broadie A role for PS integrins in morphological growth and synaptic function at the postembryonic neuromuscular junction of Drosophila Development, January 12, 1999; 126(24): 5833 - 5846. [Abstract] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help