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The Journal of Neuroscience, October 1, 1998, 18(19):7847-7855

Genetic Analysis on the Role of Integrin during Axon Guidance in Drosophila

Bao Hoang and Akira Chiba

Department of Cell and Structural Biology, University of Illinois, Urbana, Illinois 61801

Heterodimeric cell surface receptor integrin is widely expressed in the nervous system, but its specific role during axon development has not been directly tested in vivo. We show that the Drosophila nervous system expresses low levels of positron-specific (PS) integrin subunits PS1, PS2, and PS during embryonic axogenesis. Furthermore, certain subsets of neurons express higher levels of integrin mRNAs than do the rest. Null mutations in either the PS1 or PS2 subunit gene cause widespread axon pathfinding errors that can be rescued by supplying the wild-type integrin subunit to the mutant nervous system. In contrast, misexpressing either the PS1 or PS2 integrin subunit in all neurons leads to no obvious axon pathfinding errors. We propose that integrin does not itself serve as either a "clutch" constituting molecule or a specific growth cone "receptor," as proposed previously, but rather as part of a molecular network that cooperatively guarantees accurate axon guidance.

Key words: PS1; PS2; axon guidance; PS; Drosophila; growth cone; inflated; integrin; multiple edematous wings; myospheroid; neuromuscular; pathfinding

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Copyright © 1998 Society for Neuroscience  0270-6474/98/18197847-09$05.00/0

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