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The Journal of Neuroscience, October 1, 1998, 18(19):7881-7890

Basic FGF Increases Communication between Cells of the Developing Neocortex

B. Nadarajah1, H. Makarenkova2, D. L. Becker1, W. H. Evans3, and J. G. Parnavelas1

1 Department of Anatomy and Developmental Biology and 2 Medical Research Council Laboratory of Molecular Cell Biology, University College London, London WC1E 6BT, United Kingdom, and 3 Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff CF4 4XN, United Kingdom

We have found that basic fibroblast growth factor (bFGF), applied to cortical progenitor cells in vitro, produces an increase in the expression of the gap junction protein connexin (Cx) 43 and in the mRNA encoding Cx 43. This effect was evident in both proliferating and nonproliferating cells. The elevated levels of mRNA suggest that bFGF is likely to exert its effect by upregulating the rate of transcription of the Cx 43 gene. We have further shown that the increase in Cx 43 expression is mediated through the receptor tyrosine kinase pathway and is associated with enhanced intercellular dye-coupling mediated by gap junctions. These results suggest that gap junction channels provide a direct conduit for mitogens released in response to bFGF to effectively regulate proliferation during corticogenesis.

Key words: connexin 43; gap junctions; dye-coupling; bFGF; development; neocortex

Copyright © 1998 Society for Neuroscience  0270-6474/98/18197881-10$05.00/0


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