QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (35) Citing Articles via Google Scholar Google Scholar Articles by Manzoni, O. Articles by Bockaert, J. Search for Related Content PubMed PubMed Citation Articles by Manzoni, O. Articles by Bockaert, J. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB COCAINE GLUTAMIC ACID HYDROCHLORIDE THEOPHYLLINE

 Previous Article  |  Next Article 

The Journal of Neuroscience, October 1, 1998, 18(19):7996-8002

Decreased Presynaptic Sensitivity to Adenosine after Cocaine Withdrawal

Olivier Manzoni^{1, 2}, Didier Pujalte¹, John Williams², and Joël Bockaert¹

¹ Centre National de la Recherche Scientifique, Unité Propre de Recherches 9023, 34094 Montpellier Cedex 05, France, and ² Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201.

The nucleus accumbens (NAc) is a site mediating the rewarding properties of drugs of abuse, such as cocaine, amphetamine, opiates, nicotine, and alcohol ( ). Acute cocaine has been shown to decrease excitatory synaptic transmission mediated by the cortical afferents to the NAc (), but the effects of long-term cocaine treatment and withdrawal have not been explored. Here, we report that long-term (1 week) withdrawal from chronic cocaine reduced the potency of adenosine to presynaptically inhibit glutamate (Glu) release by activating adenosine A1 receptors. Adenosine A1 receptors were not desensitized, because the potency of the metabolically stable adenosine analog N⁶-cyclopentyl-adenosine was unchanged after chronic cocaine withdrawal. When adenosine transporters were blocked, the potency of adenosine to inhibit Glu release from naive and cocaine-withdrawn NAc slices was similar. These results suggest that one of the long-term consequences of cocaine withdrawal is an augmented uptake of adenosine. This long-lasting change expressed at the presynaptic excitatory inputs to the medium spiny output neurons in the NAc may help identify new therapeutic targets for the treatment of drug abuse.

Key words: nucleus accumbens; chronic cocaine; adenosine; transporter; withdrawal; drug abuse

---

Copyright © 1998 Society for Neuroscience  0270-6474/98/18197996-07$05.00/0

This article has been cited by other articles:

				C.-C. Huang, P.-C. Yang, H.-J. Lin, and K.-S. Hsu Repeated Cocaine Administration Impairs Group II Metabotropic Glutamate Receptor-Mediated Long-Term Depression in Rat Medial Prefrontal Cortex J. Neurosci., March 14, 2007; 27(11): 2958 - 2968. [Abstract] [Full Text] [PDF]

				J.-F. Chen, S. Fredduzzi, E. Bastia, L. Yu, R. Moratalla, E. Ongini, and M. A. Schwarzschild Adenosine A2A receptors in neuroadaptation to repeated dopaminergic stimulation: Implications for the treatment of dyskinesias in Parkinson's disease Neurology, December 9, 2003; 61(90116): S74 - 81. [Abstract] [Full Text]

				L. F. Agnati, S. Ferre, C. Lluis, R. Franco, and K. Fuxe Molecular Mechanisms and Therapeutical Implications of Intramembrane Receptor/Receptor Interactions among Heptahelical Receptors with Examples from the Striatopallidal GABA Neurons Pharmacol. Rev., September 1, 2003; 55(3): 509 - 550. [Abstract] [Full Text] [PDF]

				J. M. Brundege and J. T. Williams Differential Modulation of Nucleus Accumbens Synapses J Neurophysiol, July 1, 2002; 88(1): 142 - 151. [Abstract] [Full Text] [PDF]

				D. Robbe, G. Alonso, S. Chaumont, J. Bockaert, and O. J. Manzoni Role of P/Q-Ca2+ Channels in Metabotropic Glutamate Receptor 2/3-Dependent Presynaptic Long-Term Depression at Nucleus Accumbens Synapses J. Neurosci., June 1, 2002; 22(11): 4346 - 4356. [Abstract] [Full Text] [PDF]

				J. M. Brundege and J. T. Williams Increase in Adenosine Sensitivity in the Nucleus Accumbens Following Chronic Morphine Treatment J Neurophysiol, March 1, 2002; 87(3): 1369 - 1375. [Abstract] [Full Text] [PDF]

				H. Morikawa, O. J. Manzoni, J. C. Crabbe, and J. T. Williams Regulation of Central Synaptic Transmission by 5-HT1B Auto- and Heteroreceptors Mol. Pharmacol., April 13, 2001; 58(6): 1271 - 1278. [Abstract] [Full Text]

				D. Robbe, G. Alonso, F. Duchamp, J. Bockaert, and O. J. Manzoni Localization and Mechanisms of Action of Cannabinoid Receptors at the Glutamatergic Synapses of the Mouse Nucleus Accumbens J. Neurosci., January 1, 2001; 21(1): 109 - 116. [Abstract] [Full Text] [PDF]

				J. T. Williams, M. J. Christie, and O. Manzoni Cellular and Synaptic Adaptations Mediating Opioid Dependence Physiol Rev, January 1, 2001; 81(1): 299 - 343. [Abstract] [Full Text] [PDF]

				V. Neugebauer, F. Zinebi, R. Russell, J. P. Gallagher, and P. Shinnick-Gallagher Cocaine and Kindling Alter the Sensitivity of Group II and III Metabotropic Glutamate Receptors in the Central Amygdala J Neurophysiol, August 1, 2000; 84(2): 759 - 770. [Abstract] [Full Text] [PDF]

				C. D. Fiorillo and J. T. Williams Selective Inhibition by Adenosine of mGluR IPSPs in Dopamine Neurons After Cocaine Treatment J Neurophysiol, March 1, 2000; 83(3): 1307 - 1314. [Abstract] [Full Text] [PDF]

				B. A. Baldo, G. F. Koob, and A. Markou Role of Adenosine A2 Receptors in Brain Stimulation Reward under Baseline Conditions and during Cocaine Withdrawal in Rats J. Neurosci., December 15, 1999; 19(24): 11017 - 11026. [Abstract] [Full Text] [PDF]

				Y. Shoji, J. Delfs, and J. T. Williams Presynaptic Inhibition of GABAB-Mediated Synaptic Potentials in the Ventral Tegmental Area during Morphine Withdrawal J. Neurosci., March 15, 1999; 19(6): 2347 - 2355. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help