 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, January 15, 1998, 18(2):590-600
Growth Factor Receptor Tyrosine Kinases Acutely Regulate Neuronal Sodium Channels through the Src Signaling Pathway
Michael D. Hilborn1, Richard R. Vaillancourt2, and Stanley G. Rane1 1 Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, and 2 Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona 85721
Growth factor receptor tyrosine kinase (RTK)-activated signaling pathways are well established regulators of neuronal growth and development, but whether these signals provide mechanisms for acute modulation of neuronal activity is just beginning to be addressed. We show in pheochromocytoma (PC12) cells that acute application of ligands for both endogenous RTKs [trkA, basic FGF (bFGF) receptor, and epidermal growth factor (EGF) receptor] and ectopically expressed platelet-derived growth factor (PDGF) receptors rapidly inhibits whole-cell sodium channel currents, coincident with a hyperpolarizing shift in the voltage dependence of inactivation. Sodium channel inhibition by trkA and PDGF receptors is mutually occlusive, suggestive of a common signal transduction mechanism. Furthermore, specific inhibitors for trkA and PDGF RTK activities abrogate sodium channel inhibition in response to NGF and PDGF, respectively, showing that the intrinsic RTK activity of these receptors is necessary for sodium channel inhibition. Use of PDGF receptor mutants deficient for specific signaling activities demonstrated that this inhibition is dependent on RTK interaction with Src but not with other RTK-associated signaling molecules. Inhibition was also compromised in cells expressing dominant-negative Ras. These results suggest a possible mechanism for acute physiological actions of RTKs, and they indicate regulatory functions for Ras and Src that may complement the roles of these signaling proteins in long-term neuronal regulation.
Key words: PC12 cells; sodium channels; growth factor receptor tyrosine kinases; PDGF receptors; NGF; Ras; Src
Copyright © 1998 Society for Neuroscience 0270-6474/98/182590-11$05.00/0
This article has been cited by other articles:
Z. Jia, J. Bei, L. Rodat-Despoix, B. Liu, Q. Jia, P. Delmas, and H. Zhang
NGF Inhibits M/KCNQ Currents and Selectively Alters Neuronal Excitability in Subsets of Sympathetic Neurons Depending on their M/KCNQ Current Background
J. Gen. Physiol., June 1, 2008; 131(6): 575 - 587.
[Abstract] [Full Text] [PDF]
C. P. Ford, K. V. Wong, V. B. Lu, E. Posse de Chaves, and P. A. Smith
Differential Neurotrophic Regulation of Sodium and Calcium Channels in an Adult Sympathetic Neuron
J Neurophysiol, March 1, 2008; 99(3): 1319 - 1332.
[Abstract] [Full Text] [PDF]
M. Ahn, D. Beacham, R. E. Westenbroek, T. Scheuer, and W. A. Catterall
Regulation of NaV1.2 Channels by Brain-Derived Neurotrophic Factor, TrkB, and Associated Fyn Kinase
J. Neurosci., October 24, 2007; 27(43): 11533 - 11542.
[Abstract] [Full Text] [PDF]
D. Beacham, M. Ahn, W. A. Catterall, and T. Scheuer
Sites and Molecular Mechanisms of Modulation of NaV1.2 Channels by Fyn Tyrosine Kinase
J. Neurosci., October 24, 2007; 27(43): 11543 - 11551.
[Abstract] [Full Text] [PDF]
E. Carlier, V. Sourdet, S. Boudkkazi, P. Deglise, N. Ankri, L. Fronzaroli-Molinieres, and D. Debanne
Metabotropic glutamate receptor subtype 1 regulates sodium currents in rat neocortical pyramidal neurons
J. Physiol., November 15, 2006; 577(1): 141 - 154.
[Abstract] [Full Text] [PDF]
W. J. Brackenbury and M. B. A. Djamgoz
Activity-dependent regulation of voltage-gated Na+ channel expression in Mat-LyLu rat prostate cancer cell line
J. Physiol., June 1, 2006; 573(2): 343 - 356.
[Abstract] [Full Text] [PDF]
S. D. Buckingham and D. W. Ali
Computer simulations of high-pass filtering in zebrafish larval muscle fibres
J. Exp. Biol., August 15, 2005; 208(16): 3055 - 3063.
[Abstract] [Full Text] [PDF]
C. A. Ahern, J.-F. Zhang, M. J. Wookalis, and R. Horn
Modulation of the Cardiac Sodium Channel NaV1.5 by Fyn, a Src Family Tyrosine Kinase
Circ. Res., May 13, 2005; 96(9): 991 - 998.
[Abstract] [Full Text] [PDF]
S. Hong, T. J. Morrow, P. E. Paulson, L. L. Isom, and J. W. Wiley
Early Painful Diabetic Neuropathy Is Associated with Differential Changes in Tetrodotoxin-sensitive and -resistant Sodium Channels in Dorsal Root Ganglion Neurons in the Rat
J. Biol. Chem., July 9, 2004; 279(28): 29341 - 29350.
[Abstract] [Full Text] [PDF]
I. F Abdullaev, R. Z Sabirov, and Y. Okada
Upregulation of swelling-activated Cl- channel sensitivity to cell volume by activation of EGF receptors in murine mammary cells
J. Physiol., June 15, 2003; 549(3): 749 - 758.
[Abstract] [Full Text] [PDF]
S. F. Davis and C. L. Linn
Mechanism linking NMDA receptor activation to modulation of voltage-gated sodium current in distal retina
Am J Physiol Cell Physiol, May 1, 2003; 284(5): C1193 - C1204.
[Abstract] [Full Text] [PDF]
B. Soliven, L. Ma, H. Bae, B. Attali, A. Sobko, and T. Iwase
PDGF upregulates delayed rectifier via Src family kinases and sphingosine kinase in oligodendroglial progenitors
Am J Physiol Cell Physiol, January 1, 2003; 284(1): C85 - C93.
[Abstract] [Full Text] [PDF]
D. B. Carr, D. C. Cooper, S. L. Ulrich, N. Spruston, and D. J. Surmeier
Serotonin Receptor Activation Inhibits Sodium Current and Dendritic Excitability in Prefrontal Cortex via a Protein Kinase C-Dependent Mechanism
J. Neurosci., August 15, 2002; 22(16): 6846 - 6855.
[Abstract] [Full Text] [PDF]
S. Giovannardi, G. Forlani, M. Balestrini, E. Bossi, R. Tonini, E. Sturani, A. Peres, and R. Zippel
Modulation of the Inward Rectifier Potassium Channel IRK1 by the Ras Signaling Pathway
J. Biol. Chem., March 29, 2002; 277(14): 12158 - 12163.
[Abstract] [Full Text] [PDF]
M. J. Davis, X. Wu, T. R. Nurkiewicz, J. Kawasaki, P. Gui, M. A. Hill, and E. Wilson
Regulation of ion channels by protein tyrosine phosphorylation
Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H1835 - H1862.
[Abstract] [Full Text] [PDF]
S. Lei, W. F. Dryden, and P. A. Smith
Nerve Growth Factor Regulates Sodium But Not Potassium Channel Currents in Sympathetic B Neurons of Adult Bullfrogs
J Neurophysiol, August 1, 2001; 86(2): 641 - 650.
[Abstract] [Full Text] [PDF]
A. L. Purcell and T. J. Carew
Modulation of Excitability in Aplysia Tail Sensory Neurons by Tyrosine Kinases
J Neurophysiol, June 1, 2001; 85(6): 2398 - 2411.
[Abstract] [Full Text] [PDF]
D. S. Auld, F. Mennicken, and R. Quirion
Nerve Growth Factor Rapidly Induces Prolonged Acetylcholine Release from Cultured Basal Forebrain Neurons: Differentiation between Neuromodulatory and Neurotrophic Influences
J. Neurosci., May 15, 2001; 21(10): 3375 - 3382.
[Abstract] [Full Text] [PDF]
C. Sims, J. Chiu, and R. D. Harvey
Tyrosine Phosphatase Inhibitors Selectively Antagonize beta -Adrenergic Receptor-Dependent Regulation of Cardiac Ion Channels
Mol. Pharmacol., April 13, 2001; 58(6): 1213 - 1221.
[Abstract] [Full Text]
D. A. Fadool, K. Tucker, J. J. Phillips, and J. A. Simmen
Brain Insulin Receptor Causes Activity-Dependent Current Suppression in the Olfactory Bulb Through Multiple Phosphorylation of Kv1.3
J Neurophysiol, April 1, 2000; 83(4): 2332 - 2348.
[Abstract] [Full Text] [PDF]
C. Deleuze, A. Duvoid, F. C Moos, and N. Hussy
Tyrosine phosphorylation modulates the osmosensitivity of volume-dependent taurine efflux from glial cells in the rat supraoptic nucleus
J. Physiol., March 1, 2000; 523(2): 291 - 299.
[Abstract] [Full Text] [PDF]
L. A. C. Blair, K. K. Bence-Hanulec, S. Mehta, T. Franke, D. Kaplan, and J. Marshall
Akt-Dependent Potentiation of L Channels by Insulin-Like Growth Factor-1 Is Required for Neuronal Survival
J. Neurosci., March 15, 1999; 19(6): 1940 - 1951.
[Abstract] [Full Text] [PDF]
M. Narisawa-Saito, A. J. Silva, T. Yamaguchi, T. Hayashi, T. Yamamoto, and H. Nawa
Growth factor-mediated Fyn signaling regulates alpha -amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression in rodent neocortical neurons
PNAS, March 2, 1999; 96(5): 2461 - 2466.
[Abstract] [Full Text] [PDF]
H. H. D. Lam, A. Bhardwaj, M. T. O'Connell, D. F. Hanley, R. J. Traystman, and M. V. Sofroniew
Nerve growth factor rapidly suppresses basal, NMDA-evoked, and AMPA-evoked nitric oxide synthase activity in rat hippocampus in vivo
PNAS, September 1, 1998; 95(18): 10926 - 10931.
[Abstract] [Full Text] [PDF]
D. A. Fadool and I. B. Levitan
Modulation of Olfactory Bulb Neuron Potassium Current by Tyrosine Phosphorylation
J. Neurosci., August 15, 1998; 18(16): 6126 - 6137.
[Abstract] [Full Text] [PDF]
S. L. Rogalski, S. M. Appleyard, A. Pattillo, G. W. Terman, and C. Chavkin
TrkB Activation by Brain-derived Neurotrophic Factor Inhibits the G Protein-gated Inward Rectifier Kir3 by Tyrosine Phosphorylation of the Channel
J. Biol. Chem., August 11, 2000; 275(33): 25082 - 25088.
[Abstract] [Full Text] [PDF]
O. N. Osipenko, A. P. Barrie, J. M. Allen, and A. M. Gurney
Pituitary Adenylyl Cyclase-activating Peptide Activates Multiple Intracellular Signaling Pathways to Regulate Ion Channels in PC12 Cells
J. Biol. Chem., May 26, 2000; 275(22): 16626 - 16631.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|