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The Journal of Neuroscience, October 15, 1998, 18(20):8228-8235
Synaptic Potentials Mediated via
-Bungarotoxin-Sensitive Nicotinic Acetylcholine Receptors in Rat Hippocampal Interneurons
Charles J. Frazier1, Amber V. Buhler2, Jeffrey L. Weiner1, and Thomas V. Dunwiddie1, 2, 3 1 Neuroscience Program and 2 Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, and 3 Veterans Affairs Medical Research Service, Denver, Colorado 80220
Exogenous application of acetylcholine elicits inward currents in hippocampal interneurons that are mediated via
-bungarotoxin-sensitive nicotinic acetylcholine receptors, but synaptic responses mediated via such receptors have never been reported in mammalian brain. In the present study, EPSCs were evoked in hippocampal interneurons in rat brain slices by electrical stimulation and were recorded by using whole-cell voltage-clamp techniques. Nicotinic EPSCs were isolated pharmacologically, using antagonists to block other known types of ligand-gated ion channels, and then were tested with either
Key words: nicotine; hippocampus; interneuron; rat; acetylcholine; electrophysiology
Copyright © 1998 Society for Neuroscience 0270-6474/98/18208228-08$05.00/0
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