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The Journal of Neuroscience, November 1, 1998, 18(21):8614-8624

Continuous and Transient Vesicle Cycling at a Ribbon Synapse

Ned C. Rouze and Eric A. Schwartz

Department of Pharmacological and Physiological Sciences, The University of Chicago, Chicago, Illinois 60637

Optical methods were used to study the Ca2+ dependence of vesicle cycling in bipolar cells isolated from goldfish retinas. Uniformly raising the Ca2+ concentration to between 0.8 and 20 µM produced a continuous vesicle cycle of balanced exocytosis and endocytosis with a maximum rate equivalent to the turnover of the entire surface membrane of a terminal every 2 min (or ~900 vesicles sec-1). Increasing the Ca2+ concentration above 20 µM inhibited continuous vesicle cycling. In contrast, influx of Ca2+ through voltage-gated channels produced a transient burst of exocytosis that increased the surface area of a terminal by a maximum of 12% (equivalent to the addition of 13,000 vesicles). Endocytosis was delayed until after Ca2+ influx stopped and the average Ca2+ concentration in the terminal declined. Hence, a single terminal has mechanisms for both continuous and transient vesicle cycling.

Key words: exocytosis; endocytosis; vesicle cycling; synaptic vesicle; bipolar cell; retina

Copyright © 1998 Society for Neuroscience  0270-6474/98/18218614-11$05.00/0


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