 |
 Previous Article | Next Article 
The Journal of Neuroscience, November 1, 1998, 18(21):8730-8739
Endogenous Neurotrophin-3 Regulates Short-Term Plasticity at
Lateral Perforant Path-Granule Cell Synapses
Merab
Kokaia1,
Fredrik
Asztely1,
Klara
Olofsdotter1,
Carlos Balet
Sindreu1,
Dimitri M.
Kullmann2, and
Olle
Lindvall1
1 Section of Restorative Neurology, Wallenberg
Neuroscience Center, University Hospital, S-221 85 Lund, Sweden, and
2 Department of Clinical Neurology, Institute of Neurology,
Queen Square, London WC1N 3BG, United Kingdom
In the adult brain, neurotrophin-3 (NT-3) is mainly localized in
dentate granule cells, and its expression is decreased by various
stimuli, e.g., seizure activity. We have examined the role of
endogenous NT-3 for excitatory synaptic transmission at lateral
perforant path-dentate granule cell synapses using hippocampal slices
from NT-3 knock-out (+/ ) and wild-type (+/+) mice. Paired-pulse facilitation (PPF) and also short-term synaptic plasticity induced by a
brief, high-frequency train of afferent stimulation were reduced, but
the expression of long-term potentiation was not affected in the
NT-3+/ mice. Incubation of the slices with recombinant NT-3 reversed
the deficit in PPF through a mechanism requiring de novo
protein synthesis, implying that the impaired short-term plasticity
does not result from a developmental alteration. No changes of overall
presynaptic release probability, measured by the progressive block of
NMDA receptor-mediated synaptic currents by MK-801, or desensitization
of AMPA receptors were detected. Because NT-3 expression is reduced
after focal seizures, impaired short-term facilitation may represent a
protective response that limits the propagation of epileptiform
activity from the entorhinal cortex to the hippocampus.
Key words:
neurotrophin-3; synaptic plasticity; dentate gyrus; hippocampal slices; whole-cell patch-clamp; knock-out mice
Copyright © 1998 Society for Neuroscience 0270-6474/98/18218730-10$05.00/0
This article has been cited by other articles:
|
|
|
|
 
K. Shimazu, M. Zhao, K. Sakata, S. Akbarian, B. Bates, R. Jaenisch, and B. Lu
NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis
Learn. Mem.,
May 1, 2006;
13(3):
307 - 315.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Y. Sun, S. A Lyons, and L. E Dobrunz
Mechanisms of target-cell specific short-term plasticity at Schaffer collateral synapses onto interneurones versus pyramidal cells in juvenile rats
J. Physiol.,
November 1, 2005;
568(3):
815 - 840.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. S. Lein, X. Zhao, and F. H. Gage
Defining a Molecular Atlas of the Hippocampus Using DNA Microarrays and High-Throughput In Situ Hybridization
J. Neurosci.,
April 14, 2004;
24(15):
3879 - 3889.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Wang, R. Butowt, M. R. Vasko, and C. S. von Bartheld
Mechanisms of the Release of Anterogradely Transported Neurotrophin-3 from Axon Terminals
J. Neurosci.,
February 1, 2002;
22(3):
931 - 945.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Hanse and B. Gustafsson
Paired-Pulse Plasticity at the Single Release Site Level: An Experimental and Computational Study
J. Neurosci.,
November 1, 2001;
21(21):
8362 - 8369.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kokaia, K. Holmberg, A. Nanobashvili, Z.-Q. D. Xu, Z. Kokaia, U. Lendahl, S. Hilke, E. Theodorsson, U. Kahl, T. Bartfai, et al.
Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin
PNAS,
October 31, 2001;
(2001)
231496298.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Nanobashvili, M. S. Airaksinen, M. Kokaia, J. Rossi, F. Asztely, K. Olofsdotter, P. Mohapel, M. Saarma, O. Lindvall, and Z. Kokaia
Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor alpha 2
PNAS,
October 24, 2000;
97(22):
12312 - 12317.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-W. Xie, D. Sayah, Q.-S. Chen, W.-Z. Wei, D. Smith, and X. Liu
Deficient long-term memory and long-lasting long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene
PNAS,
June 23, 2000;
(2000)
140204597.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
X.-p. He, F. Yang, Z.-p. Xie, and B. Lu
Intracellular Ca2+ and Ca2+/Calmodulin-Dependent Kinase II Mediate Acute Potentiation of Neurotransmitter Release by Neurotrophin-3
J. Cell Biol.,
May 15, 2000;
149(4):
783 - 792.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Chen, R. Kolbeck, Y.-A. Barde, T. Bonhoeffer, and A. Kossel
Relative Contribution of Endogenous Neurotrophins in Hippocampal Long-Term Potentiation
J. Neurosci.,
September 15, 1999;
19(18):
7983 - 7990.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. McKay, A. L. Purcell, and T. J. Carew
Regulation of Synaptic Function by Neurotrophic Factors in Vertebrates and Invertebrates: Implications for Development and Learning
Learn. Mem.,
May 1, 1999;
6(3):
193 - 215.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
L. Ma, G. Reis, L. F. Parada, and E. M. Schuman
Neuronal NT-3 Is not Required For Synaptic Transmission or Long-Term Potentiation in Area CA1 of the Adult Rat Hippocampus
Learn. Mem.,
May 1, 1999;
6(3):
267 - 275.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C.-W. Xie, D. Sayah, Q.-S. Chen, W.-Z. Wei, D. Smith, and X. Liu
Deficient long-term memory and long-lasting long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene
PNAS,
July 5, 2000;
97(14):
8116 - 8121.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kokaia, K. Holmberg, A. Nanobashvili, Z.-Q. D. Xu, Z. Kokaia, U. Lendahl, S. Hilke, E. Theodorsson, U. Kahl, T. Bartfai, et al.
Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin
PNAS,
November 20, 2001;
98(24):
14006 - 14011.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
